Current Issue Highlights

Latest Articles

  • Image

    Trends in pediatric rheumatic heart disease in the Indonesia–Malaysia–Thailand Growth Triangle economic sub-region (Indonesia, Malaysia, and Thailand), 1990–2023: A Global burden of disease study

    Annals of Pediatric Cardiology. Sep-Oct 2026: 19(5):466-474

    Background:

    The extent to which socio-demographic development translates into reductions in rheumatic heart disease (RHD) burden in the Indonesia–Malaysia–Thailand Growth Triangle (IMT-GT) Economic Sub-Region have not been assessed. This study aimed to assess temporal trends, socio-demographic gradients, and development-adjusted performance of pediatric RHD from 1990 to 2023.

    Methods:

    Data from the Global Burden of Disease Study 2023 for Indonesia, Malaysia, and Thailand were analyzed. Age-specific incidence, mortality, and disability-adjusted life years (DALYs) were estimated by the sex. Temporal trends were assessed using generalized additive models to estimate average annual percentage changes (AAPC). The association between DALY rates and the socio-demographic index (SDI) was evaluated using elasticity analysis and performance relative to SDI-based expectations was quantified as the gap between observed and expected DALY rates.

    Results:

    Between 1990 and 2023, the burden of RHD declined across the IMT-GT sub-region, with substantial cross-country variation. AAPCs indicated modest declines in DALYs and mortality in all countries, whereas incidence showed no consistent long-term decrease. Higher SDI was significantly associated with lower DALY rates across all pediatric age groups (P < 0.001). SDI-benchmarked comparisons indicate that Indonesia has not achieved the level of DALY reduction expected for its development status, whereas Thailand has exceeded these expectations and Malaysia has remained on the predicted trajectory.

    Conclusions:

    The burden of pediatric RHD has declined in the IMT-GT Economic Sub-region over the past three decades, driven primarily by reductions in mortality. Sociodemographic development was strongly associated with lower DALY rates, but substantial cross-country differences in development-adjusted performance persist.

  • Image

    Efficacy of catheter ablation for arrhythmia in adults with congenital heart disease: A meta-analysis of clinical outcomes

    Annals of Pediatric Cardiology. Sep-Oct 2026: 19(5):475-489

    Background:

    Arrhythmias remain a major clinical challenge in adult congenital heart disease (aCHD), contributing significantly to increased hospitalization rates and cardiac complications, affecting over 50% of aCHD patients. Catheter ablation (CA) is regarded as a first-line therapeutic modality due to its potential for disease modification. However, concerns persist regarding its long-term efficacy and safety. Thus, a comprehensive evaluation of CA outcomes in this population is warranted.

    Methods:

    The outcomes of interest were the success rate, secondary ablation rate, complication rates, and recurrence of arrhythmias. Quality assessment was done using the Risk of Bias in Non-randomized Studies of Interventions tool, and meta-analysis was performed using RStudio.

    Results:

    A comprehensive search of seven databases yielded 15 articles for analysis, among which 10 were categorized as low-risk, four as moderate-risk, and one lacked information regarding bias. The single-arm meta-analysis, examining events per 100 observations, revealed a success rate of 85.37 (95% confidence interval [CI] =78.50, 92.24). Moreover, the secondary ablation rate was determined to be 29.29 (95% CI = 16.92, 41.66), while major complications occurred at a rate of 2.81 (95% CI = 0.89, 4.73) and minor complications at a rate of 5.29 (95% CI = 1.88, 8.70). The overall recurrence rate of arrhythmias was found to be 40.33 (95% CI = 28.37, 52.29), with specific rates for intra-atrial reentrant tachycardia at 20.33 (95% CI = 11.24, 29.43), atrial fibrillation at 14.25 (95% CI = 3.46, 25.05), and atrioventricular nodal reentrant tachycardia at 9.70 (95% CI = 0.00, 19.56). Lastly, the implantation rate of implantable cardioverter defibrilators (ICDs) was found to be 1.05 (95% CI = 0.12, 1.99).

    Conclusion:

    CA for arrhythmias in aCHD patients demonstrates high success rates with minimal procedural complications. However, the substantial recurrence rates highlight the need for ongoing monitoring and proactive strategies to optimize long-term outcomes.

Most Popular Articles

Featured Jobs