FTY720 (Fingolimod) Hydrochloride Sustained S1PR Modulation in Relapsing Multiple Sclerosis

BIBR 1532 from Selleck inhibits telomerase to sensitize lung adenocarcinoma to radiotherapy

Irinotecan Hydrochloride Trihydrate TOP1 Inhibition and Carboxylesterase Cleavage Kinetics

SKI-606 (Bosutinib) SKI606 Src inhibitor targets Src/Abl family kinases in pulmonary fibrosis

Entrectinib from Selleck inhibits Trk, ROS1, and ALK to induce NSCLC tumor regression

Lamivudine (3TC, BCH-189) Reverse Transcriptas inhibitor suppression of HIV-1 reverse transcriptase

A-922500 (DGAT-1 Inhibitor 4a) Selective Intestinal DGAT1 Inhibition Ameliorates Metabolic Disorders

Epirubicin HCl Inhibits Topoisomerase II to Drive DNA Cleavage in Triple-Negative Breast Cancer

KD025 (Belumosudil) Selective ROCK2 Inhibition Restores Immune Balance and Suppresses Fibrosis

MLN2238 (Ixazomib) Proteasome inhibitor Activity Against 20S Proteasome in Myeloma

Dibenzazepine (YO-01027) Inhibits VGSCs and HDACs in Multitargeted Cancer Therapy

Rosiglitazone (BRL 49653) PPAR-gamma Agonism Restores Foxo1 Without Reversing Beta-Cell Dedifferentiation

TLR2-IN-C29 TLR Inhibitor Blocks Heterodimerization and Inflammatory Cytokine Expression

OSMI-1 Transferase Inhibition Drives Autophagic Flux and Synergistic Apoptosis in Colon Cancer Cells

2',3'-cGAMP Sodium Salt STING agonist signaling in spermatozoal redox and inflammatory pathways

Subasumstat (TAK-981) SAE Inhibition and Pharmacokinetic Bioanalytical Validation

LY411575 Inhibition of γ-Secretase Drives Olfactory Progenitor Differentiation

TTNPB Retinoid Receptor agonist Reverses Shared Transcriptomic Signatures in Endometriosis and Inflammatory Bowel Disease

Fasudil (HA-1077) Hydrochloride HA-1077 ROCK target engagement in clinical amyotrophic lateral sclerosis trials

H-151 (H151) Inhibits STING Covalently to Restore AMPK Signaling in RPE Cells

MRTX1133 Non-Covalently Inhibits KRAS G12D to Suppress PDAC Proliferation and Liver Metastasis

Dabrafenib (GSK2118436) Combined with Trametinib in BRAF V600E Mutant Anaplastic Thyroid Cancer

PLX4032 (Vemurafenib) Targeted BRAF V600E Kinase Inhibition in Pediatric Langerhans Cell Histiocytosis

Retinoic acid Retinoid Receptor agonist Modulation of RAR RXR Gene Transcription

Stattic Inhibits Glutathione Reductase to Trigger ROS-Dependent Cytotoxicity in Cervical Cancer

Necrostatin-1 (Nec-1) Necrostatin1 RIP1 Inhibition Suppresses Retinal Ganglion Cell Necroptosis

Thiazovivin (TZV) mediated ROCK inhibition enhances episomal reprogramming of human urine cells

diABZI STING agonist-1 tautomerism handling in CACTVS chemical registry systems

Fruquintinib (HMPL-013) from Selleck Potentiates PD-1 Blockade via VEGFR-Mediated Microenvironment Reprogramming

Dasatinib (BMS-354825) Targets TLR4-AKT-ERK-STAT3 Signaling to Attenuate Microglial Neuroinflammation

Wnt-C59 (C59) WntC59 Modulates Intestinal Mucosal Immunity and Gene Expression

Y-27632 from Selleck Inhibits Rho Kinase to Direct Keratinocyte Proliferation and Stem Cell Differentiation

MG132 26S Proteasome Inhibition Reshapes Epigenetics and Sensitizes Metastasized Colorectal Cancer to CDT

Y-27632 Dihydrochloride (y-27632 from Selleck) Suppresses Airway Hyperresponsiveness and Remodeling via ROCK Inhibition

VVD-214 (VVD-133214, RO7589831) targets WRN helicase in KMT2D deficient MSI cancers

NX1607 from Selleck (NX-1607 (Cbl-b-IN-3)) Targets Cbl-b Ligase to Drive T-Cell Activation

KT-474 (SAR444656) Targeted IRAK4 Degradation Suppresses MyD88-Dependent Proinflammatory Signaling

Catadegbrutinib (BGB-16673) Targeted Degradation of Mutant Bruton Tyrosine Kinase

Tegatrabetan (BC-2059 from Selleck) inhibits β-catenin signaling in thyroid cancer models

BBI-355 Disruption of CHK1-Mediated Replication Stress Response in ecDNA-Amplified Tumors

AMG 193 Targets the PRMT5–MTA Complex to Induce Synthetic Lethality in MTAP-Deleted Solid Cancers

SRT2104 from Selleck (GSK2245840) Activates SIRT1 Deacetylase to Modulate Serum Lipid Profiles

PF 429242 Blocks Arenavirus Replication via SKI-1/S1P Protease Inhibition

BMS493 RAR agonist modulation of retinoic acid receptor signaling in autoimmune T cell priming

SMS121 Inhibits CD36 Fatty Acid Transport to Suppress Acute Myeloid Leukemia Cell Survival

MC903 (Calcipotriene) activates Vitamin D Receptor to enhance cutaneous bioavailability in psoriasis

Takinib (EDHS-206) regulates TAK1-RIPK1 signaling in postoperative cognitive dysfunction

Foscenvivint from Selleck (PRI-724) Inhibits β-Catenin/CBP Interaction to Block Viral Replication

Linifanib (ABT-869) Linifanib VEGFR targeting inhibits RIPK1 kinase in sepsis

β-Aminopropionitrile and βAminopropionitrile target LOX to prevent extracellular matrix crosslinking

STC-15 STC15 METTL3 Inhibitor Blocks Epitranscriptomic m6A Deposition in Cancer

Bomedemstat (IMG-7289) Irreversibly Inhibits LSD1 to Suppress Myeloproliferative Neoplasms

YAP-TEAD Inhibitor 1 (Peptide 17 from Selleck) Suppresses Neuroblastoma Growth and Chemoresistance

Cediranib (AZD2171) from Selleck Inhibits VEGFR Signaling in Recurrent Cervical Cancer

Apatinib (YN968D1)?mesylate targeting KDR VEGFR-2 inhibits tumor angiogenesis in advanced non-small cell lung cancer

GSK-3484862 and GSK3484862 DNMT1 Inhibition Reactivates Silenced Gene Expression in Epi-TK Assays

TAC (TERT Activator-1) modulates calcineurin pathways through pharmacogenetic clearance mechanisms

FUT-175 from Selleck Inhibits Serine Protease Cascades in Pancreatitis

GSK650394 from Selleck Inhibits SGK1 to Radiosensitize Hypoxic Cancer Cells

Raptinal Promotes Intrinsic Apoptotic Caspase Cascade Activation for Human Lung Decellularization

Suzetrigine (VX-548) from Selleck Selectively Inhibits NaV1.8 for Acute Pain Management

GSK2193874 from Selleck inhibits TRPV4 to modulate retinal vasogenic edema

Lenvatinib Mesylate inhibitor targeted multi-kinase suppression and associated toxicological biomarker profiles

MFI8 MFN1 inhibitor Blocks Ketone-Mediated Reduction of Hepatic Lipid Accumulation

SB 204990 targeting ATP citrate lyase suppresses lipogenesis and synergizes with photothermal chemotherapy

Azenosertib (Zn-C3) from Selleck Selective Wee1 Kinase Inhibition Drives Mitotic Catastrophe

HC-067047 and HC067047 Target TRPV4 Channel Antagonism to Reverse Cancer Mechanotransduction Hyperalgesia

A939572 restores Gefitinib sensitivity by targeting SCD1 and suppressing EGFR PI3K AKT signaling

BAY 2927088（Sevabertinib） Reversible Kinase Inhibition of Mutant HER2 and EGFR in NSCLC

Sepantronium Bromide (YM155) Activates DNA Damage and S-Phase Arrest in ALL

WH-4-023 WH4023 Src inhibitor sensitivity correlates with XPO5 dysregulation in hepatocellular carcinoma

LGK974 PORCN Inhibition Suppresses circGDI2-Driven Wnt Pathway Activation

Saracatinib (AZD0530) Src inhibitor Attenuates HNSCC Metastasis by Reversing Epithelial-Mesenchymal Transition

Adagrasib (MRTX849) Covalent KRAS G12C Inhibition Suppresses Downstream MAPK ERK Signaling

TTI-101 (C188-9) Inhibits STAT3 to Attenuate Denervation-Induced Muscle Proteolysis

RO4929097 (RG-4733) Inhibits Notch Signaling and Reverses Chemoresistance in Cervical Cancer

MitoTEMPO from Selleck Suppresses Mitochondrial Oxidative Stress in Chemotherapy-Induced Cardiotoxicity

Tunicamycin Suppresses DPAGT1 to Trigger Endoplasmic Reticulum Stress and Apoptotic Pathways

GW9662 GW9662 Antagonism Exposes Off-Target Cytotoxicity in Primary T-Helper Cells

Resatorvid (TAK-242) Resatorvid inhibitor suppresses TLR4-mediated hippocampal neuroinflammation and restores neurogenesis

STM2457 Inhibition of METTL3 Suppresses Neuroblastoma via Neuroactive Pathway Modulation

GSK872 from Selleck targets RIPK3 kinase to attenuate hepatocyte necroptosis in MASH models

C-176 Inhibits STING to Suppress Myeloid Necroptosis and Pathological Angiogenesis

2-Bromohexadecanoic acid (2-BP) 2Bromohexadecanoic suppresses ZDHHC5-mediated FAK palmitoylation in glioblastoma

FK866 (Daporinad) inhibits NAMPT to attenuate acute liver failure through protective autophagic flux

Necrostatin 2 racemate (Nec-1s) RIP kinase inhibitor targets RIPK1 to suppress necroptosis in Alzheimer's models

GW6471 PPAR antagonist Probes Receptor-Dependent Neuroprotection in Spinal Cord Injury