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Sex and the genome

Nature Genetics volume 36, pages 548–549 (2004) Cite this article

The genetic composition of sex chromosomes has been deciphered, in part, through large-scale gene expression studies in different species. A new study in mice adds a missing piece of the puzzle: the composition of the X chromosome in mammals is influenced by inactivation of the sex chromosomes during male meiosis.

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Figure 1: Genes expressed during early spermatogenesis (before MSCI) are enriched on the X chromosome (purple), in accordance with Rice's hypothesis.
The alternative text for this image may have been generated using AI.

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Authors and Affiliations

  1. Department of Genetics, Yale University School of Medicine, New Haven, Connecticut, USA

    Valerie Reinke

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  1. Valerie Reinke
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Reinke, V. Sex and the genome. Nat Genet 36, 548–549 (2004). https://doi.org/10.1038/ng0604-548

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