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Secreted miRNAs suppress atherogenesis

Nature Cell Biology volume 14, pages 233–235 (2012) Cite this article

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Endothelial–vascular smooth muscle cell communication has a critical role in cardiovascular homeostasis and the pathogenesis of atherosclerosis. A study now demonstrates extracellular-vesicle-mediated transfer of the atheroprotective microRNAs miR-143/145 between endothelial and vascular smooth muscle cells, providing compelling evidence that intercellular transport of miRNAs can influence a pathological process, namely atherosclerosis.

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Figure 1: Endothelial–VSMC communication through extracellular vesicles of atheroprotective miRNAs.
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References

  1. Potente, M., Gerhardt, H. & Carmeliet, P. Cell 146, 873–887 (2011).

    Article  CAS  Google Scholar 

  2. Gaengel, K., Genove, G., Armulik, A. & Betsholtz, C. Arterioscl. Throm. Vasc. 29, 630–638 (2009).

    Article  CAS  Google Scholar 

  3. Davis, S. et al. Cell 87, 1161–1169 (1996).

    Article  CAS  Google Scholar 

  4. Pardali, E., Goumans, M.-J. & ten Dijke, P. Trends Cell Biol. 20, 556–567 (2010).

    Article  CAS  Google Scholar 

  5. Carvalho, R. L. et al. J. Cell Sci. 120, 4269–4277 (2007).

    Article  CAS  Google Scholar 

  6. Hergenreider, E. et al. Nat. Cell Biol. 14, 249–256 (2012).

    Article  CAS  Google Scholar 

  7. Chiu, J. J. & Chien, S. Physiol. Rev. 91, 327–387 (2011).

    Article  Google Scholar 

  8. Atkins, G. B. & Jain, M. K. Circ. Res. 100, 1686–1695 (2007).

    Article  CAS  Google Scholar 

  9. Fledderus, J. O. et al. Arterioscl. Throm. Vasc. 28, 1339–1346 (2008).

    Article  CAS  Google Scholar 

  10. Kuo, C. T. et al. Genes Dev. 11, 2996–3006 (1997).

    Article  CAS  Google Scholar 

  11. Lee, J. S. et al. Dev. Cell 11, 845–857 (2006).

    Article  CAS  Google Scholar 

  12. Boettger, T. et al. J. Clin. Invest. 119, 2634–2647 (2009).

    Article  CAS  Google Scholar 

  13. Cordes, K. R. et al. Nature 460, 705–710 (2009).

    Article  CAS  Google Scholar 

  14. Elia, L. et al. Cell Death Differ. 16, 1590–1598 (2009).

    Article  CAS  Google Scholar 

  15. Skog, J. et al. Nat. Cell Biol. 10, 1470–1476 (2008).

    Article  CAS  Google Scholar 

  16. Collino, F. et al. PLoS ONE 5, e11803 (2010).

    Article  Google Scholar 

  17. Vickers, K. C., Palmissano, B. T., Shoucri, B. M., Shamburek, R. D. & Remaley, A. T. Nat. Cell Biol. 13, 423–433 (2011).

    Article  CAS  Google Scholar 

  18. Yoshida, T., Gan, Q. & Owens, G. K. Am. J. Physiol.-Cell Phys. 295, C1175–C1182 (2008).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Daniel J. Rader and Michael S. Parmacek are at the Cardiovascular Institute and the Institute for Translational Medicine and Therapeutics, University of Pennsylvania, Perelman School of Medicine, 11–125 Translational Research Center, 3400 Civic Center Boulevard, Building 421, Philadelphia, Philadelphia 19104-5156, USA,

    Daniel J. Rader & Michael S. Parmacek

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  1. Daniel J. Rader
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  2. Michael S. Parmacek
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Correspondence to Daniel J. Rader.

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Rader, D., Parmacek, M. Secreted miRNAs suppress atherogenesis. Nat Cell Biol 14, 233–235 (2012). https://doi.org/10.1038/ncb2452

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