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Clinical features and treatment in patients with acute 2,4-dinitrophenol poisoning

  • Published: 08 March 2011
  • Volume 12, pages 189–192 (2011)
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Journal of Zhejiang University SCIENCE B Aims and scope Submit manuscript
Clinical features and treatment in patients with acute 2,4-dinitrophenol poisoning
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  • Yuan-qiang Lu1,
  • Jiu-kun Jiang1 &
  • Wei-dong Huang1 
  • 467 Accesses

  • 34 Altmetric

  • 3 Mentions

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Abstract

Objective

To report clinical features and treatment of 16 cases of acute 2,4-dinitrophenol poisoning.

Methods

A total of 16 patients suffering from acute poisoning due to non-oral exposure to 2,4-dinitrophenol were sent to our hospital. Two died within 3 h after admission, while the other 14 responded to supportive treatment and hemoperfusion. Clinical features and treatment of the patients were retrospectively analyzed and presented.

Results

Fourteen patients recovered and were discharged after four to six weeks of treatment. No obvious poisoning sequelae were found in the three-month follow-up.

Conclusions

Non-oral exposure to 2,4-dinitrophenol is toxic. Hemoperfusion and glucocorticoid treatments may be efficient measures to prevent mortality, but this requires further study.

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Authors and Affiliations

  1. Department of Emergency, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China

    Yuan-qiang Lu, Jiu-kun Jiang & Wei-dong Huang

Authors
  1. Yuan-qiang Lu
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  2. Jiu-kun Jiang
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  3. Wei-dong Huang
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Corresponding author

Correspondence to Wei-dong Huang.

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Cite this article

Lu, Yq., Jiang, Jk. & Huang, Wd. Clinical features and treatment in patients with acute 2,4-dinitrophenol poisoning. J. Zhejiang Univ. Sci. B 12, 189–192 (2011). https://doi.org/10.1631/jzus.B1000265

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  • Received: 08 July 2010

  • Revised: 10 November 2010

  • Published: 08 March 2011

  • Issue date: March 2011

  • DOI: https://doi.org/10.1631/jzus.B1000265

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Key words

  • 2,4-Dinitrophenol
  • Poisoning
  • Therapeutics
  • Hemoperfusion
  • Glucocorticoid

CLC number

  • R135.1

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