UP FRONT MATTERS: Special Article

Blood Pressure Control in Chronic Kidney Disease

Is Less Really More?

Lewis, Julia B.

Author Information

Division of Nephrology and Hypertension, Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee

Correspondence: Dr. Julia B. Lewis, Division of Nephrology and Hypertension, Department of Medicine, S-2332 Medical Center North, Vanderbilt University School of Medicine, Nashville, TN 37232-2372. Phone: 615-343-6105; Fax: 615-343-7156; E-mail: [email protected]

Journal of the American Society of Nephrology 21(7):p 1086-1092, July 2010. | DOI: 10.1681/ASN.2010030236

Abstract

BP control is critical in the treatment of patients with chronic kidney disease. Recent guidelines now recommend a BP goal of <130/80 mmHg. Clinical trials using a randomized, intention-to-treat design have not established the benefits of this goal; rather, observational data and secondary or subgroup analyses drove the development of the new guidelines. A variety of observations suggest potential adverse events associate with achieving too low a BP in patients with chronic kidney disease, and ongoing randomized trials will have to establish the benefits or risks of meeting this goal.

Copyright © 2010 The Authors. Published by Wolters Kluwer Health, Inc. All rights reserved.

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