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Emerging Functions of Extracellular Pyridine Nucleotides

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Abstract

In addition to the well-known metabolic functions of NAD and NADP, it is rapidly emerging that these 2 pyridine nucleotides and their derivatives also play important roles in cell signaling. Surprisingly, a number of NAD(P) metabolizing enzymes and NAD(P) targets have been found on the outer surface of the plasma membrane and the presence of NAD has been confirmed in extracellular fluids. These findings have opened the door to a new field of research aimed at elucidating the contribution of extracellular pyridine nucleotides in physiological signaling pathways and pathological conditions.

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Authors and Affiliations

  1. DiSCAFF and the DFB Centre, Università del Piemonte Orientale, Via Bovio 6, 28100, Novara, Italy

    Richard A Billington & Armando A Genazzani

  2. DIMES, Section of Biochemistry, and Center of Excellence for Biomedical Research, University of Genova, Viale Benedetto XV/1, 16132, Genova, Italy

    Santina Bruzzone, Antonio De Flora & Elena Zocchi

  3. Institute of Immunology, Dept. of Clinical Pathology, University Medical Center Hamburg-Eppendorf, D-20246, Hamburg, Germany

    Friedrich Koch-Nolte

  4. Department of Molecular Biology, University of Bergen, Thormohlensgt. 55, 5020, Bergen, Norway

    Mathias Ziegler

Authors
  1. Richard A Billington
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  2. Santina Bruzzone
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  3. Antonio De Flora
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  4. Armando A Genazzani
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  5. Friedrich Koch-Nolte
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  6. Mathias Ziegler
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  7. Elena Zocchi
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Correspondence to Armando A Genazzani.

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Billington, R.A., Bruzzone, S., De Flora, A. et al. Emerging Functions of Extracellular Pyridine Nucleotides. Mol Med 12, 324–327 (2006). https://doi.org/10.2119/2006-00075.Billington

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  • DOI: https://doi.org/10.2119/2006-00075.Billington