CCAR2

CCAR2
Identificadores
Alias	CCAR2, DBC-1, DBC1, KIAA1967, NET35, p30 DBC, p30DBC, cell cycle and apoptosis regulator 2
IDs externos	OMIM: 607359 MGI: 2444228 HomoloGene: 10910 GeneCards: CCAR2
Ontología génica
Función molecular	• RNA polymerase II complex binding; • GO:0048551 enzyme inhibitor activity; • GO:0001948, GO:0016582 unión a proteína plasmática; • enzyme binding; • unión a ARN (RNA); • nuclear receptor coactivator activity;
Componente celular	• citoplasma; • Nucleoplasma; • DBIRD complex; • Matriz mitocondrial; • spliceosomal complex; • núcleo celular;
Proceso biológico	• mitochondrial fragmentation involved in apoptotic process; • GO:0048553 negative regulation of catalytic activity; • GO:0009373 regulation of transcription, DNA-templated; • regulation of protein stability; • positive regulation of DNA damage checkpoint; • proceso rítmico; • positive regulation of canonical Wnt signaling pathway; • mRNA processing; • regulation of DNA-templated transcription, elongation; • regulation of protein deacetylation; • negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage; • vía de señalización WNT; • transcription, DNA-templated; • cellular response to DNA damage stimulus; • regulation of circadian rhythm; • negative regulation of cell growth; • Splicing de ARN; • negative regulation of proteasomal ubiquitin-dependent protein catabolic process; • positive regulation of apoptotic process; • regulation of cellular response to heat; • ciclo celular; • GO:0045996 negative regulation of transcription, DNA-templated; • response to UV; • GO:0097285 apoptosis; • positive regulation of nucleic acid-templated transcription;
	Fuentes: Amigo / QuickGO
Ortólogos
	57805
	219158
	ENSG00000158941
	ENSMUSG00000033712
	Q8N163
	Q8VDP4
	NM_021174; NM_199205; NM_001363068; NM_001363069; NM_001393997
	NM_146055
	NP_066997; NP_001349997; NP_001349998
	NP_666167
	Wikidata
Ver/Editar Humano	Ver/Editar Ratón

El regulador del ciclo celular y de la apoptosis 2 -CCAR2 -(anteriormente KIAA1967,) también conocida como Deleted in Breast Cancer 1, es una proteína que en humanos está codificada por el gen CCAR2.^[3]^[4]^[5]

Función

Estudios recientes muestran que DBC1 es un inhibidor de la desacetilasa de tipo sirtuina, SIRT1, que desacetila histonas y p53.^[6]^[7] Es probable que DBC1 regule la actividad de SIRT1 o desacetilasas relacionadas detectando los productos o sustratos solubles de la reacción de desacetilación dependiente de NAD.^[8]

Significación clínica

Existen 55 enfermedades descritas que coinciden con CCAR2^[9]

Referencias

↑ «Human PubMed Reference:».
↑ «Mouse PubMed Reference:».
↑ «Entrez Gene: KIAA1967 KIAA1967».
↑ «Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins». DNA Res. 8 (6): 319-27. December 2001. PMID 11853319. doi:10.1093/dnares/8.6.319.
↑ «DBC2, a candidate for a tumor suppressor gene involved in breast cancer». Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13647-52. October 2002. PMC 129730. PMID 12370419. doi:10.1073/pnas.212516099.
↑ «DBC1 is a negative regulator of SIRT1». Nature 451 (7178): 583-6. January 2008. PMID 18235501. doi:10.1038/nature06500.
↑ «Negative regulation of the deacetylase SIRT1 by DBC1». Nature 451 (7178): 587-90. January 2008. PMC 2866287. PMID 18235502. doi:10.1038/nature06515.
↑ «Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of Sirtuin domain deacetylases by NAD metabolites». Cell Cycle 7 (10): 1467-72. May 2008. PMC 2423810. PMID 18418069. doi:10.4161/cc.7.10.5883.
↑ «MalaCards». Consultado el 7 de enero de 2026.

Enlaces externos

En HomoloGene: CCAR2

En Genome:CCAR2
En MalaCards.Enfermedades que coinciden con:CCAR2
En Estudio de asociación del genoma completo (GWAS) CCAR2

Datos: Q18044644

[1] «Human PubMed Reference:».

[2] «Mouse PubMed Reference:».

[entrez-3] «Entrez Gene: KIAA1967 KIAA1967».

[pmid11853319-4] «Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins». DNA Res. 8 (6): 319-27. December 2001. PMID 11853319. doi:10.1093/dnares/8.6.319.

[pmid12370419-5] «DBC2, a candidate for a tumor suppressor gene involved in breast cancer». Proc. Natl. Acad. Sci. U.S.A. 99 (21): 13647-52. October 2002. PMC 129730. PMID 12370419. doi:10.1073/pnas.212516099.

[pmid18235501-6] «DBC1 is a negative regulator of SIRT1». Nature 451 (7178): 583-6. January 2008. PMID 18235501. doi:10.1038/nature06500.

[pmid18235502-7] «Negative regulation of the deacetylase SIRT1 by DBC1». Nature 451 (7178): 587-90. January 2008. PMC 2866287. PMID 18235502. doi:10.1038/nature06515.

[pmid18418069-8] «Analysis of DBC1 and its homologs suggests a potential mechanism for regulation of Sirtuin domain deacetylases by NAD metabolites». Cell Cycle 7 (10): 1467-72. May 2008. PMC 2423810. PMID 18418069. doi:10.4161/cc.7.10.5883.

[9] «MalaCards». Consultado el 7 de enero de 2026.

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