query stringlengths 25 224 | text stringlengths 258 3.3k | pmid stringlengths 2 8 | directness stringclasses 2
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N-(2-cyanoethylene)-urea immunostimulation DS carcinosarcoma Wistar rats | [Demonstration of tumor inhibiting properties of a strongly immunostimulating low-molecular weight substance. Comparative studies with ifosfamide on the immuno-labile DS carcinosarcoma. Stimulation of the autoimmune activity for approx. 20 days by BA 1, a N-(2-cyanoethylene)-urea. Novel prophylactic
A report is given o... | 22 | direct | semantic |
reverse phase ion pair chromatography with 1 heptane sulfonate for opium alkaloids | Application of reverse phase ion-pair partition chromatography to drugs of forensic interest.
A method is described for determining a wide range of abused drugs by using 1 column, a single isocratic system, and a fixed wavelength (254 nm) ultraviolet detector. Paired-ion chromatography is performed on a reverse phase m... | 19415 | indirect | semantic |
rotavirus gastroenteritis associated with Reye's syndrome and encephalitis | Central nervous system involvement in patients with rotavirus gastroenteritis.
Two children with rotavirus gastroenteritis are presented. The first case developed a fatal Reye's syndrome and the other one encephalitis with slow recovery. The rotavirus diagnosis was made in both cases by electron microscopy and a signif... | 204984 | direct | semantic |
hypercholesterolemia induced endothelial dysfunction flow dependent dilation coronary arteries | Endothelial function in human coronary arteries in vivo. Focus on hypercholesterolemia.
To examine whether and to what extent hypercholesterolemia may affect the vasoactive role of the endothelium before the onset of angiographically visible atherosclerosis in the coronary circulation, we studied normal subjects (group... | 1917002 | indirect | semantic |
Viola yedoensis alkaloids anti-complement activity classical and alternative pathway inhibition | [Anti-complement alkaloids from whole plants of Viola yedoensis].
Fifteen alkaloids were isolated from the 95% ethanol extract of the whole plants of Viola yedoensis by various column chromatographic techniques such as silica gel and Sephadex LH-20. Their structures were identified as neoechinulin A(1),N-benzoyl-L-p-hy... | 29493149 | direct | semantic |
phallic mobilization for intravesical phallus in covered cloacal exstrophy | Genital Mobilization of Intravesical Phallus Associated With Covered Cloacal Exstrophy: A Case Report.
Cloacal exstrophy is the most severe form of the exstrophy-epispadias complex, occurring in approximately 1 of every 200,000 to 400,000 live births. Variant such as covered cloacal exstrophy presentations are only one... | 29505857 | indirect | semantic |
reduced-fluence photodynamic therapy outcomes for subfoveal retinal pigment epithelial detachment in central serous chorioretinopathy | PHOTODYNAMIC THERAPY FOR SYMPTOMATIC SUBFOVEAL RETINAL PIGMENT EPITHELIAL DETACHMENT IN CENTRAL SEROUS CHORIORETINOPATHY: Outcomes and Prognostic Factors.
To report the clinical outcomes of reduced-fluence photodynamic therapy (PDT) for symptomatic subfoveal retinal pigment epithelial detachment (RPED) in central serou... | 29517581 | direct | semantic |
diagnostic accuracy of lung ultrasound versus chest X-ray for postoperative pulmonary complications after cardiothoracic surgery | Lung ultrasound compared with chest X-ray in diagnosing postoperative pulmonary complications following cardiothoracic surgery: a prospective observational study.
Postoperative pulmonary complications are common after cardiothoracic surgery and are associated with adverse outcomes. The ability to detect postoperative p... | 29529332 | direct | semantic |
glucose pretreatment with multiple laser pulses for Nd:YAG laser treatment of port-wine stain vessels | Glucose in Conjunction with Multiple Laser Pulses on Laser Treatment of Port-wine Stain: An in vivo Study.
Port-wine stain (PWS) birthmark is a congenital microvascular malformation of the skin. A 1064-nm Nd:YAG laser can achieve a deeper treatment, but the weak absorption by blood limits its clinical application. Mult... | 29542044 | direct | semantic |
trimethylsilyl tag protein ligand interaction NMR dissociation constant cysteine labeling | Trimethylsilyl tag for probing protein-ligand interactions by NMR.
Protein-ligand titrations can readily be monitored with a trimethylsilyl (TMS) tag. Owing to the intensity, narrow line shape and unique chemical shift of a TMS group, dissociation constants can be determined from straightforward 1D <sup1</supH-NMR spec... | 29564580 | direct | keywords |
dorsal column stimulation for glenohumeral arthritis pain | Treatment of glenohumeral arthritis pain utilizing spinal cord stimulation.
Dorsal column stimulation may be utilized to treat non-neuropathic pain attributed to glenohumeral arthritis. An 84-year-old female presented with right shoulder pain for 3 years. She was diagnosed with glenohumeral arthritis and a complete los... | 29576905 | indirect | semantic |
arbuscular mycorrhizal ectomycorrhizal shared non-mycorrhizal fungi temperate forest generalists | Root-Associated Fungi Shared Between Arbuscular Mycorrhizal and Ectomycorrhizal Conifers in a Temperate Forest.
Arbuscular mycorrhizal and ectomycorrhizal symbioses are among the most important drivers of terrestrial ecosystem dynamics. Historically, the two types of symbioses have been investigated separately because ... | 29593682 | direct | keywords |
Bayesian estimation protonation sites 1H NMR chemical shift titration | Bayesian estimation of the number of protonation sites for urinary metabolites from NMR spectroscopic data.
To aid the development of better algorithms for [Formula: see text]H NMR data analysis, such as alignment or peak-fitting, it is important to characterise and model chemical shift changes caused by variation in p... | 29606928 | indirect | keywords |
validity and reliability of pediatric hematology oncology patient acuity tool | Validity and reliability of a pediatric hematology oncology patient acuity tool.
Appropriate use of nursing resources in the pediatric hematology and oncology inpatient settings demands a patient acuity system that is easy to use and accurate, and that objectively measures nursing care needs of a specialized patient po... | 1930802 | direct | semantic |
transcatheter coil embolization and stent implantation for coronary artery fistula with concurrent occlusion | How to treat the combination of coronary artery fistula and occluded coronary artery: A case report.
Coronary artery fistulae (CAF) are uncommon and are reported in 0.25% of patients undergoing routine coronary angiography. The combination of severe coronary artery disease and a CAF was rare. A 76-year-old man presente... | 29620668 | indirect | semantic |
left sided predominance of facial and body asymmetry in rhinoplasty patients | Laterality and Left-sidedness in the Nose, Face, and Body: A New Finding.
Asymmetry is a common occurrence in bilaterian animals, particularly human beings. Through examination of patients and their photographs during rhinoplasty, we noted wider left-sided nasal and facial features in most patients. This observation le... | 29632770 | direct | semantic |
GIS buffer analysis for long-term care service gaps in declining populations | [A Study on the Number of Offices for Home-Visit/Outpatient Day Long-Term Care in Noto Area, Based on Estimated Population - Analysis Using the Geographic Information System].
There has been a noticeable population decline in the Noto area. The Ministry of Land, Infrastructure, Transport and Tourism has determined the ... | 29650867 | direct | semantic |
self-regulatory resource depletion predicting bedtime procrastination after resisting desires | Too Depleted to Turn In: The Relevance of End-of-the-Day Resource Depletion for Reducing Bedtime Procrastination.
<iBedtime procrastination</i is an important predictor of sleep insufficiency in the general population (Kroese et al., 2014b), but little is known about the determinants of this self-undermining behavior. ... | 29662459 | direct | semantic |
X-ray crystallography of anesthetic complexes with soluble proteins apoferritin | Structural Analysis of Anesthetics in Complex with Soluble Proteins.
Anesthetics interact with a broad range of different targets, including both soluble and membrane-bound proteins. Understanding these interactions at the molecular level requires detailed structural knowledge of anesthetic-protein complexes, and one o... | 29673532 | indirect | semantic |
Hyodo score prediction of aspiration during endoscopic swallowing evaluation | Predictive value of the Hyodo score in endoscopic evaluation of aspiration during swallowing.
The Hyodo scoring system during the endoscopic procedure has been proposed as a new tool for evaluating oral intake feasibility. However, the effectiveness of the information obtained from this procedure in predicting aspirati... | 29685505 | direct | semantic |
Taxodium hybrid 118 drought stress recovery proline photosynthesis | [Response in cuttings of Taxodium hybrid 'Zhongshanshan' and their parents to drought and re-hydration.]
In this study, three different strains of Taxodium hybrid 'Zhongshanshan' varieties [T. hybrid 302 (T. distichum♀×T. mucronatum♂), T. hybrid 407 (T. mucronatum♀×T. distichum♂), T. hybrid 118 (T. hybrid 302 ♀×T. macr... | 29696839 | direct | semantic |
perceived catchability affordance control running to intercept fly balls | The affordance of catchability in running to intercept fly balls.
How do outfielders control their locomotor behavior in running to catch fly balls? This question has been the topic of many empirical studies. It is interesting that a little addressed but highly relevant issue in this regard is that of the influence of ... | 29708378 | indirect | semantic |
LX-miR library CRISPR-Cas9 screen for microRNA cell fitness | MicroRNA-focused CRISPR-Cas9 library screen reveals fitness-associated miRNAs.
MicroRNAs (miRNAs) are post-transcriptional gene regulators that play important roles in the control of cell fitness, differentiation, and development. The CRISPR-Cas9 gene-editing system is composed of the Cas9 nuclease in complex with a si... | 29720387 | direct | semantic |
C-touch system role in affective touch and autism spectrum disorder development | Social touch and human development.
Social touch is a powerful force in human development, shaping social reward, attachment, cognitive, communication, and emotional regulation from infancy and throughout life. In this review, we consider the question of how social touch is defined from both bottom-up and top-down pers... | 29731417 | direct | semantic |
hypoxia effect on mitochondrial protein composition cerebral cortex aging | Effect of hypoxia on mitochondrial protein composition of cerebral cortex during aging.
The effect of hypoxia on the protein composition of mitochondria from cerebral cortex of rats at 4, 12, and 24 months of age was investigated. The proteins were separated by electrophoresis on SDS polyacrylamide gels and the percent... | 1944772 | direct | semantic |
trends in place of death at home or hospice for gynecologic cancer versus other female cancers | Trends in Place of Death Among Patients With Gynecologic Cancer in the United States.
To describe the change over time in place of death (hospital, home, hospice) among all women in the United States who died of gynecologic malignancies and compare them with other leading causes of female cancer deaths. This is a retro... | 29742673 | indirect | semantic |
bioprinted skin substitutes with vascularization using synthetic and natural building blocks | Skin bioprinting: a novel approach for creating artificial skin from synthetic and natural building blocks.
Significant progress has been made over the past few decades in the development of in vitro-engineered substitutes that mimic human skin, either as grafts for the replacement of lost skin, or for the establishmen... | 29754201 | direct | semantic |
optic nerve sheath ultrasound transcranial Doppler pupillary reactivity traumatic brain injury prediction | Through the looking glass: early non-invasive imaging in TBI predicts the need for interventions.
Early diagnosis and treatment of traumatic brain injury (TBI) lead to better outcomes. It is difficult to predict which patients benefit from specialised centres, leading to over triage or delay in definitive care. We prop... | 29766062 | indirect | keywords |
ad libitum milk replacer feeding butyrate supplementation calf sucking behavior immune response | Effects of ad libitum milk replacer feeding and butyrate supplementation on behavior, immune status, and health of Holstein calves in the postnatal period.
Animal welfare in dairy calf husbandry depends on calf rearing and is probably improved by intensive milk feeding programs. In addition, butyrate supplementation in... | 29778472 | direct | semantic |
organic thin-film transistor sensors integrated with proteins enzymes and biocompatible polymers for biosensing | Integration of Biomaterials into Sensors Based on Organic Thin-Film Transistors.
Sensors based on organic thin-film transistors (OTFTs) present various advantages, including high sensitivity and mechanical flexibility, thus possessing potential applications such as wearable devices and biomedical electronics for health... | 29790213 | indirect | semantic |
evolution of coiled tracheae in birds driven by sexual selection | Vocal specialization through tracheal elongation in an extinct Miocene pheasant from China.
Modifications to the upper vocal tract involving hyper-elongated tracheae have evolved many times within crown birds, and their evolution has been linked to a 'size exaggeration' hypothesis in acoustic signaling and communicatio... | 29802379 | indirect | semantic |
low phytanic acid DHA effects on activated microglia compared to standard DHA in neurotoxic injury | Effects of Low Phytanic Acid-Concentrated DHA on Activated Microglial Cells: Comparison with a Standard Phytanic Acid-Concentrated DHA.
Docosahexaenoic acid (DHA, 22:6 n-3) is an essential omega-3 (ω-3) long chain polyunsaturated fatty acid of neuronal membranes involved in normal growth, development, and function. DHA... | 29846873 | direct | semantic |
TTF1 nanoparticle induced hepatoma apoptosis endoplasmic reticulum stress pathway | [Mechanism of TTF1-NP induced implanted hepatoma tumor apoptosis in nude mice by endoplasmic reticulum stress pathway].
This study was designed to investigate the effect of 5,2’,4’-trihydroxy-6,7,5’-trimethoxy flavone nanoparticle(TTF1-NP) on inducing apoptosis of implanted tumour cells in nude mice and the mechanism o... | 29859020 | indirect | semantic |
cardiac rehabilitation exercise training cardiac events arrhythmias risk stratification | Retrospective analysis of cardiac events during cardiac rehabilitation at Centre Hospitalier de Luxembourg during 2014 and 2015.
The benefits of cardiac rehabilitation are well accepted. However, there still remains a debate concerning the risk of cardiac events, especially arrhythmias, during exercise training. The go... | 29870184 | direct | keywords |
OCT1 polymorphisms proguanil bioactivation cycloguanil hepatocellular concentrations | OCT1 Deficiency Affects Hepatocellular Concentrations and Pharmacokinetics of Cycloguanil, the Active Metabolite of the Antimalarial Drug Proguanil.
Cycloguanil, the active metabolite of proguanil, acts on malaria schizonts in erythrocytes and hepatocytes. We analyzed the impact of the organic cation transporter OCT1 o... | 29882324 | direct | keywords |
modelling antibody combining sites from sequence hypervariable loop prediction side chain conformation | Modelling antibody combining sites: a review.
The combining site in an antibody is built up from six hypervariable loop regions, three from the light chain and three from the heavy chain. Three-dimensional structures have been elucidated by X-ray crystallographic studies for a variety of combining sites and for four pr... | 1959453 | direct | semantic |
beta tungsten manganese monolayer giant in-plane magnetocrystalline anisotropy spintronics | β-tungsten: a promising metal for spintronics.
Ultrathin films of β-tungsten provide very promising substrates for applications in spintronics, and the possibility of incorporating them into multilayers extends such expectations. Our calculations indicate that it is viable to deposit a single layer of Mn on two non-equ... | 29893723 | direct | semantic |
McaS csgD mRNA endonucleolytic cleavage RNase E biofilm | sRNA-dependent control of curli biosynthesis in Escherichia coli: McaS directs endonucleolytic cleavage of csgD mRNA.
Production of curli, extracellular protein structures important for Escherichia coli biofilm formation, is governed by a highly complex regulatory mechanism that integrates multiple environmental signal... | 29905843 | direct | keywords |
Desulfitobacterium hafniense Y51 lactate fumarate limitation chemostat Wood-Ljungdahl pathway | Metabolic flexibility of a prospective bioremediator: Desulfitobacterium hafniense Y51 challenged in chemostats.
Desulfitobacterium hafniense Y51 has been widely used in investigations of perchloroethylene (PCE) biodegradation, but limited information exists on its other physiological capabilities. We investigated how ... | 29921035 | direct | keywords |
multiscale study of three-stage plastic flow in alpha-titanium using acoustic emission | Complexity and Anisotropy of Plastic Flow of α-Ti Probed by Acoustic Emission and Local Extensometry.
Current progress in the prediction of mechanical behavior of solids requires understanding of spatiotemporal complexity of plastic flow caused by self-organization of crystal defects. It may be particularly important i... | 29932438 | direct | semantic |
sub-Saharan Africa non-malaria febrile illness outpatient testing proportion routine data | How Far Are We from Reaching Universal Malaria Testing of All Fever Cases?
Universal malaria diagnostic testing of all fever cases is the first step in correct malaria case management. However, monitoring adherence to universal testing is complicated by unreliable recording and reporting of the true number of fever cas... | 29943717 | indirect | keywords |
PI intrinsic vulnerability assessment shallow aquifers southwestern Nigeria sedimentary basin | Intrinsic vulnerability assessment of shallow aquifers of the sedimentary basin of southwestern Nigeria.
The shallow groundwater of the multi-layered sedimentary basin aquifer of southwestern Nigeria was assessed based on its intrinsic vulnerability property. The vulnerability evaluation involves determining the protec... | 29955248 | direct | semantic |
pulmonary hypertension multiparametric biomarker panel peripheral venous blood | Biomarkers in Pulmonary Hypertension.
Biomarkers are tools in pulmonary hypertension (PH) management. They may address risk assessment, disease progression, response to medical and surgical therapy, risk of right heart failure, and prognosis. The activation of molecular pathways is the pathophysiological underpinning o... | 29966636 | direct | keywords |
determining RuBisCO catalytic constants using RuBP carboxylation | Extraction of RuBisCO to Determine Catalytic Constants.
RuBisCO enables net carbon fixation through the carboxylation of RuBP during photosynthesis. Its complex biochemistry and catalytic diversity found among different plants make characterization of RuBisCO properties useful for investigations aimed at improving phot... | 29978405 | direct | semantic |
robust feature sampling strategy for selecting highly correlated causal genes in high dimensional genomic data | A Feature Sampling Strategy for Analysis of High Dimensional Genomic Data.
With the development of high throughput technology, it has become feasible and common to profile tens of thousands of gene activities simultaneously. These genomic data typically have sample size of hundreds or fewer, which is much less than the... | 29990199 | direct | semantic |
epigenetic regulation of Toll-like receptors in type 1 diabetes pathogenesis | Epigenetic regulation of Toll-like receptors and its roles in type 1 diabetes.
The immune system can be divided into adaptive immunity and innate immunity. Adaptive immunity has been confirmed to be involved in the pathogenesis of autoimmune diseases, including type 1 diabetes (T1D). However, the role of innate immunit... | 30003291 | direct | semantic |
T cell antigen receptor constant beta chain HLA DQw1 ulcerative colitis Japanese patients | HLA-DR, DQ and T cell antigen receptor constant beta genes in Japanese patients with ulcerative colitis.
We studied the T cell antigen receptor (TcR) constant beta chain genes on HLA typed Japanese patients with ulcerative colitis (UC). A TcR constant beta EcoRI 6.0-kb fragment was present in all Japanese UC patients (... | 1973647 | direct | semantic |
persistent fatigue in early rheumatoid arthritis treat-to-target strategy with depression predictors | Fatigue in early, intensively treated and tight-controlled rheumatoid arthritis patients is frequent and persistent: a prospective study.
Fatigue has a large impact on quality of life and is still unmanageable for many patients. Study aims were describe (1) the prevalence and pattern of fatigue over time in patients wi... | 30014260 | indirect | semantic |
isavuconazole trailing effect Candida species EUCAST | Isavuconazole is highly active in vitro against Candida species isolates but shows trailing effect.
Isavuconazole is a triazole previously shown to have potent in vitro activity against Aspergillus spp., Mucorales and Candida spp. Unlike other azoles, it is unclear whether isavuconazole induces a trailing effect. We st... | 30025834 | direct | semantic |
increased prefrontal activity aging compensatory shift versus reduced specificity multivariate fMRI | Increased Prefrontal Activity with Aging Reflects Nonspecific Neural Responses Rather than Compensation.
Elevated prefrontal cortex activity is often observed in healthy older adults despite declines in their memory and other cognitive functions. According to one view, this activity reflects a compensatory functional p... | 30037829 | direct | semantic |
association between cognitive function and quality of life in bariatric surgery candidates | Cognitive function and quality of life in bariatric surgery candidates.
Both poor quality of life (QoL) and cognitive impairment are common in persons with severe obesity. Work in other patient populations show that cognitive impairment is associated with poorer QoL, though this possibility has not been examined in bar... | 30049594 | direct | semantic |
pregnancy immunoregulation Alzheimer's risk first trimester protection | Women's Pregnancy Life History and Alzheimer's Risk: Can Immunoregulation Explain the Link?
Pregnancy is associated with improvement in immunoregulation that persists into the geriatric phase. Impaired immunoregulation is implicated in Alzheimer's disease (AD) pathogenesis. Hence, we investigate the relationship betwee... | 30060670 | direct | keywords |
non-coding RNA biomarkers for antidepressant treatment response | Using Epigenetic Tools to Investigate Antidepressant Response.
Major depressive disorder is a chronic and debilitating illness. It is most commonly treated with antidepressant drugs, however, as the majority of patients do not respond on their first trial or following several adequate trials, there is great interest in... | 30072056 | direct | semantic |
atypical Mongolian spots persistent presentation screening for lysosomal storage diseases | A comprehensive review of Mongolian spots with an update on atypical presentations.
Mongolian spots (MS) are grayish-blue macules that typically present in the lumbosacral and gluteal regions of newborns. They are mostly benign and tend to resolve with age. This review brings to light recent findings and disorders asso... | 30083796 | direct | semantic |
workplace injury cost estimation industrial accidents South Korea government policy | Costs of injuries and ill health in the workplace in South Korea.
Industrial accidents affect the sustainable development of any country, enterprise or individual. This study estimated the costs of loss due to industrial accidents in South Korea in 2013, based on the 4th Korean Working Conditions Survey. The total cost... | 30095045 | indirect | semantic |
in-pixel amplifier count rate capabilities polycrystalline silicon TFT photon counting arrays | Theoretical investigation of the count rate capabilities of in-pixel amplifiers for photon counting arrays based on polycrystalline silicon TFTs.
Photon counting arrays (PCAs), capable of measuring the spectral information of individual x-ray photons and recording that information digitally, provide a number of advanta... | 30106180 | direct | semantic |
tissue oxygen saturation in dogs with hemorrhagic shock versus healthy controls | Tissue oxygen saturation in dogs with acute hemorrhage.
To evaluate initial tissue hemoglobin oxygen saturation (StO<sub2</sub ) in dogs presenting to an emergency room (ER) for acute hemorrhage. Prospective, observational study. University veterinary teaching hospital. Thirty-eight dogs with acute hemorrhage were enro... | 30117666 | indirect | semantic |
leucovorin polyglutamylation enhances fluoropyrimidine cytotoxicity via thymidylate synthase inhibition | Role of folylpolyglutamates in biochemical modulation of fluoropyrimidines by leucovorin.
The growth-inhibitory effect of fluoropyrimidines combined with a short-term exposure to leucovorin and the pattern of polyglutamylation of folates were compared between parental CCRF-CEM cells and a cell line with impaired abilit... | 1988119 | direct | semantic |
rate boundary conditions for bifurcation instability in hyperelastic soft tissues | On Rate Boundary Conditions for Soft Tissue Bifurcation Analysis.
Mechanical instability of soft tissues can either risk their normal function or alternatively trigger patterning mechanisms during growth and morphogenesis processes. Unlike standard stability analysis of linear elastic bodies, for soft tissues undergoin... | 30128553 | direct | semantic |
two-channel spectrometer BSI-CMOS detector integrated sub-gratings simultaneous spectra | A High-Performance Spectrometer with Two Spectral Channels Sharing the Same BSI-CMOS Detector.
Optical spectrometers play an important role in modern scientific research. In this work, we present a two-channel spectrometer with a pixel resolution of better than 0.1 nm/pixel in the wavelength range of 200 to 950 nm and ... | 30139954 | direct | semantic |
ischemic strangulation of epiploic appendage through omental defect causing distant appendagitis | Ischemic Strangulation of a Giant Epiploic Appendage through an Omental Defect: a Case Report.
We report a rare case of an epiploic appendage twisted through an omental defect, resulting in an epiploic appendagitis at a distance to the colonic wall. The 59-year-old women complained of low abdominal pain and alguria, pr... | 30151482 | direct | semantic |
comparing ProFile Vortex and ProTaper Next for removal of gutta-percha time efficiency | Comparing ProFile Vortex to ProTaper Next for the efficacy of removal of root filling material: An <i>ex vivo</i> micro-computed tomography study.
This study compared the efficacy of ProFile Vortex (PV) with that of ProTaper Next (PTN) for the removal of root canal filling material. Twenty-six mesial canals of extracte... | 30166873 | direct | semantic |
CHO cell lactogenic behavior PKM-1 pyruvate kinase isoform knockout | Pyruvate Kinase Muscle-1 Expression Appears to Drive Lactogenic Behavior in CHO Cell Lines, Triggering Lower Viability and Productivity: A Case Study.
Chinese hamster ovary (CHO) cell lines are used to express a variety of therapeutic proteins. However, lactogenic behavior displayed by some CHO cell lines during manufa... | 30179303 | indirect | keywords |
OLF induced thoracic myelopathy AOLF ratio diagnostic cutoff | Clinically significant radiographic parameter for thoracic myelopathy caused by ossification of the ligamentum flavum.
To investigate radiographic parameters to improve the accuracy of radiologic diagnosis for ossification of ligamentum flavum (OLF)-induced thoracic myelopathy and thereby establish a useful diagnostic ... | 30191306 | direct | keywords |
ED discharge risk prediction Charlson comorbidity index prolonged length of stay | A Risk Score to Predict Short-term Outcomes Following Emergency Department Discharge.
The emergency department (ED) is an inherently high-risk setting. Risk scores can help practitioners understand the risk of ED patients for developing poor outcomes after discharge. Our objective was to develop two risk scores that pr... | 30202497 | indirect | semantic |
surface atomic structure effect on oxygen exchange kinetics in Nb-doped SrTiO3 perovskite | Influence of surface atomic structure demonstrated on oxygen incorporation mechanism at a model perovskite oxide.
Perovskite oxide surfaces catalyze oxygen exchange reactions that are crucial for fuel cells, electrolyzers, and thermochemical fuel synthesis. Here, by bridging the gap between surface analysis with atomic... | 30213926 | direct | semantic |
consolidated bioprocessing of cellulose to itaconic acid in metabolically engineered Neurospora crassa | Consolidated bioprocessing of lignocellulosic biomass to itaconic acid by metabolically engineering Neurospora crassa.
Neurospora crassa is a filamentous fungus potent in secreting cellulase and degrading lignocellulosic materials. Here, heterologous cis-aconitic acid decarboxylase was expressed in N. crassa to synthes... | 30225531 | direct | semantic |
PP4 deficiency DNA replication stress impairs immunoglobulin class switch recombination | PP4 deficiency leads to DNA replication stress that impairs immunoglobulin class switch efficiency.
The serine/threonine phosphatase PP4 has been implicated in DNA damage repair and cell cycle regulation through its dephosphorylation of specific substrates. We previously showed that PP4 is required for mouse B cell dev... | 30237510 | direct | semantic |
vitamin A excess or deficiency effects on Escherichia coli infection mortality and T lymphocyte response in chicks | Decreased resistance and immune response to Escherichia coli infection in chicks with low or high intakes of vitamin A.
The effects of vitamin A excess of insufficiency on resistance to Escherichia coli infection and subsequent anti-E. coli immune response were examined in chicks. Chicks receiving depleted (0 microgram... | 2002410 | direct | semantic |
general versus specific cancer worry screening uptake breast cervical colorectal | Cancer worries and uptake of breast, cervical, and colorectal cancer screening: A population-based survey in England.
Some degree of general worry about cancer may facilitate screening participation, but specific worries about the potential consequences (e.g. treatment, death) may act as deterrents. No studies have exa... | 30249158 | direct | keywords |
combination therapy desmopressin propiverine protocol primary nocturnal enuresis children | Primary Nocturnal Enuresis: A Novel Therapeutic Strategy With Higher Efficacy.
To introduce a new protocol for patients with primary nocturnal enuresis to increase efficacy of treatment and decrease relapse rate. A prospective study was done on 185 children diagnosed with nocturnal enuresis between the years 2007 and 2... | 30261177 | direct | semantic |
co-transcriptional splicing control of cassette exons by exon-intron structure context | Mathematical modeling identifies potential gene structure determinants of co-transcriptional control of alternative pre-mRNA splicing.
The spliceosome catalyzes the removal of introns from pre-messenger RNA (mRNA) and subsequent pairing of exons with remarkable fidelity. Some exons are known to be skipped or included i... | 30272246 | direct | semantic |
xeno-free generation of clinical-grade red blood cells from umbilical cord blood mononuclear cells | Generation of clinical-grade red blood cells from human umbilical cord blood mononuclear cells.
A xeno-free method for ex vivo generation of red blood cells (RBCs) is attempted in order to replicate for large-scale production and clinical applications. An efficient milieu was formulated using injectable drugs substitut... | 30284087 | direct | semantic |
pediatric proteinuria hematuria monogenic nephritis nephrosis AS aHUS SRNS mutation prevalence | Panel sequencing distinguishes monogenic forms of nephritis from nephrosis in children.
Alport syndrome (AS) and atypical hemolytic-uremic syndrome (aHUS) are rare forms of chronic kidney disease (CKD) that can lead to a severe decline of renal function. Steroid-resistant nephrotic syndrome (SRNS) is more common than A... | 30295827 | direct | keywords |
Th1 Th2 cytokine bias ovine lymph nodes early pregnancy maternal fetal tolerance | Comparison of Th1 and Th2 cytokines production in ovine lymph nodes during early pregnancy.
As a fetal allograft to the mother, early conceptus regulates the intrauterine immune and systemic immune responses during early pregnancy in sheep. However, expression of T helper 1 (Th1) and Th2 cytokines in maternal lymph nod... | 30308394 | direct | semantic |
Au multi-oxide yolk shell nanospheres redox self assembly etching synthesis | A general one-pot strategy for the synthesis of Au@multi-oxide yolk@shell nanospheres with enhanced catalytic performance.
By integrating redox self-assembly and redox etching processes, we report a general one-pot strategy for the synthesis of Au@multi-M <sub<ix</i</sub O <sub<iy</i</sub (M = Co, Ce, Fe, and Sn) yolk@... | 30319758 | direct | keywords |
defining optimal microbiota in agriculture criteria domestication antimicrobial use | How Can We Define "Optimal Microbiota?": A Comparative Review of Structure and Functions of Microbiota of Animals, Fish, and Plants in Agriculture.
All multicellular organisms benefit from their own microbiota, which play important roles in maintaining the host nutritional health and immunity. Recently, the number of s... | 30333981 | direct | semantic |
animal tissue bioavailability of anthocyanins cyanidin-3-glucoside quantification | Anthocyanin Tissue Bioavailability in Animals: Possible Implications for Human Health. A Systematic Review.
Anthocyanins (ACNs) are promising health-enhancing phenolic compounds. We focus on ACN animal tissue bioavailability to provide an evidentiary link between tissue ACNs and their associated health properties. We p... | 30345762 | direct | semantic |
anti-TNF IR rheumatoid arthritis golimumab mavrilimumab IL-6 predictive biomarker | Pharmacodynamic biomarkers and differential effects of TNF- and GM-CSF-targeting biologics in rheumatoid arthritis.
The aim of our study was to identify pharmacodynamic biomarkers and assess differential effects of tumor necrosis factor (TNF)- and non-TNF-targeting agents on rheumatoid arthritis (RA) patients with an i... | 30358109 | direct | keywords |
MiIII MiVI glycophorin delta-alpha-delta hybrid genes pseudoexon gene conversion | Molecular genetics of human erythrocyte MiIII and MiVI glycophorins. Use of a pseudoexon in construction of two delta-alpha-delta hybrid genes resulting in antigenic diversification.
Human glycophorins alpha and delta (or A and B) specify the MNSs blood group antigens; they exhibit considerable structural variation amo... | 2016325 | direct | keywords |
in vivo biomechanical properties uterosacral ligament suspension strength stiffness | [An in vivo biomechanical study of Chinese female with uterosacral ligament suspension].
<bObjective:</b To measure in vivo biomechanical properties of pelvic support structures associated with uterosacral ligament suspension (ULS) . <bMethods:</b Ten Chinese female cadavers (death within 48 hours) without embalming we... | 30369127 | direct | semantic |
potassium chloride effect on hydration number and dehydration of methylxanthines | Effect of potassium chloride on the solvation behavior of caffeine, theophylline and theobromine: Volumetric, viscometric, calorimetry and spectroscopic approach.
The density (ρ), speed of sound (u), viscosity (η) and enthalpy of dilution (q) measurements for methylxanthines (caffeine, theophylline and theobromine) in ... | 30381165 | direct | semantic |
curcumin niosome nanoemulsion membrane-mediated transfer hydrophobic drug delivery | Critical parameters dictating efficiency of membrane-mediated drug transfer using nanoparticles.
Curcumin, a low molecular weight, hydrophobic compound, exhibits strong anti-cancer effects and has a high margin of safety. However, its poor water solubility, rapid metabolism and degradation make it relatively ineffectiv... | 30393168 | direct | keywords |
challenges of patient partnership in research role boundaries and researcher identity | [The challenges faced by researchers involving patients as partners in research].
This review presents recent findings from the literature on the challenges that researchers may face, when patients get involved as partners in research: which patients to recruit, how to clarify and set boundaries to the roles of the pat... | 30404714 | indirect | semantic |
heterotopic quadruplet pregnancy after ICSI ampullary ectopic intrauterine triplet | Heterotopic Quadruplet Pregnancy After ICSI Conception.
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pubmed-abstract-ir-simulated-search-queries
A PubMed retrieval dataset with simulated specialist search queries and abstract-level positive targets.
This dataset contains 2,355,329 query-document pairs derived from PubMed title-and-abstract records.
Each row is designed so that the associated PubMed record is a positive retrieval target for the generated query.
The queries were generated with a Qwen3.5-35B-A3B model quantized to NVFP4, and were intentionally constructed to resemble realistic specialist search behavior rather than a single idealized query form.
The dataset is intended for information retrieval research and engineering over biomedical text. It mixes more direct paper-finding queries with broader, more indirect discovery-oriented queries. It also mixes fluent semantic search formulations with compressed keyword-style queries. The goal is to approximate the range of queries that a biomedical retrieval system may encounter in practice, rather than producing only polished benchmark-style questions.
The source corpus is slinusc/PubMedAbstractsSubset.
For this release, the retrieval text is stored as text, which is the original generation source text built from the paper title followed by a newline and the abstract.
The PubMed identifier is preserved as pmid so each row can be traced back to the underlying source record.
Loading the dataset
from datasets import load_dataset
ds = load_dataset(
"hotchpotch/pubmed-abstract-ir-simulated-search-queries",
split="train",
streaming=True,
)
row = next(iter(ds))
print(row)
License
This dataset is derived from slinusc/PubMedAbstractsSubset, using the upstream dataset as accessed on April 11, 2026. The upstream dataset card declares the source data license as:
- CC0 1.0 Universal (
cc0-1.0)
This README follows that upstream declaration. If you need to validate redistribution or downstream commercial use for a specific workflow, check the upstream dataset card as well.
Technical report
Dataset structure
The dataset uses the following top-level columns, in this exact order.
| Column | Type | Meaning |
|---|---|---|
query |
string |
Generated search query intended to resemble realistic specialist search behavior for finding a paper or strongly related papers. |
text |
string |
Source-side paper text used during generation, represented as title + "\n" + abstract. |
pmid |
string |
Original PubMed paper identifier preserved for traceability. |
directness |
string |
Whether the query was generated to target the paper more directly or more indirectly. |
query_style |
string |
Whether the query was generated in a more semantic natural-language style or a more compressed keyword style. |
query is the simulated user search input and text is the positive retrieval target text.
pmid is retained so downstream users can join back to PubMed metadata or recover the original source record when needed.
Example row:
| Column | Value |
|---|---|
query |
N-(2-cyanoethylene)-urea immunostimulation DS carcinosarcoma Wistar rats |
text |
[Demonstration of tumor inhibiting properties of a strongly immunostimulating low-molecular weight substance. Comparative studies with ifosfamide on the immuno-labile DS carcinosarcoma. Stimulation of the autoimmune activity for approx. 20 days by BA 1, a N-(2-cyanoethylene)-urea. Novel prophylactic A report is given on the recent discovery of outstanding immunological properties in BA 1 [N-(2-cyanoethylene)-urea] having a (low) molecular mass M = 111.104. Experiments in 214 DS carcinosarcoma be... |
pmid |
22 |
directness |
direct |
query_style |
semantic |
Control semantics
directness
| Field | Description |
|---|---|
| Type | string |
| Values | direct, indirect |
| What it controls | How directly the generated query is expected to target the paper's contribution, result, or topic. |
| Why it matters | It broadens supervision from direct known-item search toward more exploratory biomedical retrieval. |
| Value | Meaning |
|---|---|
direct |
The query is phrased to target the paper or its main contribution relatively directly. |
indirect |
The query approaches the paper from a more oblique or discovery-oriented angle while remaining strongly related. |
query_style
| Field | Description |
|---|---|
| Type | string |
| Values | semantic, keywords |
| What it controls | The surface form of the generated query. |
| Why it matters | It introduces stylistic variation between natural-language search and compressed expert keyword search. |
| Value | Meaning |
|---|---|
semantic |
A more natural-language or phrase-based search query. |
keywords |
A more compressed keyword-oriented search query with fewer function words. |
Empirical distribution
The following counts describe the released dataset after filtering.
directness
| Value | Rows | Share |
|---|---|---|
direct |
1,765,196 | 74.9% |
indirect |
590,133 | 25.1% |
query_style
| Value | Rows | Share |
|---|---|---|
semantic |
1,766,595 | 75.0% |
keywords |
588,734 | 25.0% |
Construction methodology
Step 1. Define the source retrieval corpus
Start from a PubMed title-and-abstract corpus containing a stable PubMed identifier, a title, and an abstract for each record. For the release used here, the generation run considered 2,392,165 source rows. The key design decision is to treat the title-plus-abstract text as the retrieval target. The generation problem is therefore asymmetric: given a paper record, generate a specialist search query for which that record would be a plausible positive hit.
Step 2. Define the generation objective
For each paper record, ask a Qwen3.5-35B-A3B model quantized to NVFP4 to generate one search query in English.
The target behavior is a query that a biomedical researcher or technically literate user might realistically type when trying to find that paper or closely related work.
The generator should not be restricted to one idealized style.
Instead, it should cover both more direct known-item-like queries and more indirect discovery-oriented queries, together with both semantic and keyword-heavy query forms.
Step 3. Sample categorical controls before generation
Before generating the query for a paper record, sample two categorical control variables:
directnessquery_style
In the current generator, both controls are sampled with a 3:1 bias toward the more standard setting.
| Control | Sampling policy |
|---|---|
directness |
direct:indirect = 3:1 |
query_style |
semantic:keywords = 3:1 |
Step 4. Filter to the final retrieval dataset
The intended export keeps only rows that satisfy all of the following:
ok == truestatus == "ok"error == nullreason == nullvalidity_score == 1
This keeps the exported dataset focused on usable positive IR pairs while preserving the two generation-control columns and the PubMed identifier.
In practice, the generation run started from 2,392,165 source rows and the final export retained 2,355,329 rows. This corresponds to a retention rate of 98.5% relative to the input rows considered by the run.
Author
- Yuichi Tateno (@hotchpotch)

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