The quiet reservoir: Understanding Shiga toxin Escherichia coli O157:H7 colonization in cattle

Katherine P. Feldmann, Phillip R. Myer

PLOS Pathogens: published September 10, 2026 | https://doi.org/10.1371/journal.ppat.1014565

Convergent evolution of viral nucleases targeting cyclic dinucleotides

Zichen Li, Leiliang Zhang

PLOS Pathogens: published September 15, 2026 | https://doi.org/10.1371/journal.ppat.1014605

Many hosts, many solutions: How reservoirs shape Borrelia protein diversity

Sára Ciglbauerová, Martin Strnad, Ryan O. M. Rego

PLOS Pathogens: published September 16, 2026 | https://doi.org/10.1371/journal.ppat.1014583

Exploring glycocalyx components powering the contact between Entamoeba histolytica and bacteria during non-opsonic phagocytosis

Elisabeth Labruyère, Thomas Treport, Jean-Christophe Olivo-Marin, Nancy Guillen

PLOS Pathogens: published September 21, 2026 | https://doi.org/10.1371/journal.ppat.1014560

Rab10 coordinates SADS-CoV non-lytic egress through the ERGIC-TGN-lysosome trafficking pathway

Liaoyuan Zhang, Jiyu Zhang, Mei Xue, Mengyu Liu, Xinwei Sun, Dakai Liu, Miaomiao Zeng, Gengting Gu, Hongyan Shi, Xin Zhang, Jianfei Chen, Zhaoyang Ji, Da Shi, Li Feng

PLOS Pathogens: published September 1, 2026 | https://doi.org/10.1371/journal.ppat.1014569

Plasmodium falciparum subverts neutrophil function via host miR-451a loaded extracellular vesicles driving bacterial and fungal superinfection susceptibility

Kehinde Adebayo Babatunde, Mtakai Ngara, Paola Martinez Murillo, Bibin Subramanian, Alex Hopke, Simone Lucchesi, Maria Novedrati, Giorgio Montesi, Francesco Santoro, Michael Hagemann-Jensen, Rickard Sandberg, Luis Filgueira, Michael Walch, Daniel Irimia, Pierre-Yves Mantel

PLOS Pathogens: published September 1, 2026 | https://doi.org/10.1371/journal.ppat.1014533

Hypervirulence-associated pseudo-compound transposons as fundamental mobile units driving cross-species virulence dissemination in Enterobacteriaceae

Shuaihua Fan, Lijun Wang, Chao Liu, Haoran Li, Huaiqing Qi, Pengcheng Du, Jun Guo

PLOS Pathogens: published September 1, 2026 | https://doi.org/10.1371/journal.ppat.1014513

Acidic and alkaline conditions enhance Staphylococcus aureus α-toxin pore formation and cytotoxicity

Tristan J. van der Linden, Arnab Chatterjee, Lisette M. Scheepmaker, Debajyoti Chakraborty, Somnath Dutta, Bart W. Bardoel, András N. Spaan

PLOS Pathogens: published September 1, 2026 | https://doi.org/10.1371/journal.ppat.1014568

The TRAF6-Akt axis is required for efficient lytic replication of KSHV

Zhenshan Liu, Qingyu Guo, Weili Wang, Hongjia Lu, Tianyu Yu, Tingting Li, Qiming Liang

PLOS Pathogens: published September 1, 2026 | https://doi.org/10.1371/journal.ppat.1014557

A global map of the Zika virus phosphoproteome reveals host-driven regulation of viral particle release and cytopathogenicity

Inessa Manuelyan, Anna M. Schmoker, Boyd L. Yount Jr., Philip Eisenhauer, Judith I. Keller, Clarissa Gold, Dante Terino, Christopher M. Ziegler, Jeff Alexander, Edward Hutchinson, David Bhella, Christopher D. Syme, Douglas G. Widman, Mark T. Heise, Ralph S. Baric, Bryan A. Ballif, Jason W. Botten

PLOS Pathogens: published September 3, 2026 | https://doi.org/10.1371/journal.ppat.1014300

Complete disruption of gD binding to HVEM alters virus replication and host receptor homeostasis

Deepak Arya, Kati Tormanen, Jay J. Oh, Shaohui Wang, Homayon Ghiasi

PLOS Pathogens: published September 8, 2026 | https://doi.org/10.1371/journal.ppat.1014566

Exploring the functions of NKG7 in CD4⁺ and CD8⁺ T cells during malaria

Teija C-M. Frame, Fabian de Labastida Rivera, Nicholas L. Dooley, Jessica A. Engel, Jinrui Na, Yulin Wang, Luzia Bukali, Susanna S. Ng, Patrick T. Bunn, Lynette Beattie, Gunter Hartel, Timothy William, Matthew J. Grigg, Nicholas M. Anstey, James S. McCarthy, Bridget E. Barber, Michelle J. Boyle, Christian R. Engwerda

PLOS Pathogens: published September 8, 2026 | https://doi.org/10.1371/journal.ppat.1013528

TRIM23 prevents adenovirus replication by p62-mediated selective autophagic degradation of viral E1A protein

Nan Sun, Jikai Zhang, Banruo Xia, Hang Yin, Jiaqian Xie, Xiaoxiao Liu, Man Li, Lin Fang, Guijuan Ji, Gaolei Ma, Haihan Zhang, Zhenzhen Wang, Dafei Chai, Gang Wang

PLOS Pathogens: published September 8, 2026 | https://doi.org/10.1371/journal.ppat.1014578

PRMT3 restricts porcine epidemic diarrhea virus replication by disrupting the interaction between VAPA and the viral nucleocapsid protein

He-Yong Wu, Shu-Yu Zhong, Ao-Si Qi, Zi-Ru Wang, Qiu-Se Tu, Feng Li, Rui Wu, Jing-Yao Wang, Fan Song, Tian-Yi Zhang, Ting Li, Qing-Chun Yu, Hong-Ming Yuan, Dong-Mei Lv, Hong-Sheng Ouyang, Xi-Liang Du, Da-Xin Pang, Zi-Cong Xie

PLOS Pathogens: published September 8, 2026 | https://doi.org/10.1371/journal.ppat.1014599

Bile acid sequestration reveals microbiome remodeling that dominates FXR signaling to shape host responses to enteric infection

Anahita Mansouripour, Drew R. Seeger, Meredith Parmer, Peddanna Kotha, Anton M. Golovko, Mikhail Y. Golovko, Shahram Solaymani-Mohammadi

PLOS Pathogens: published September 8, 2026 | https://doi.org/10.1371/journal.ppat.1014558

Dual plasmepsin IX and X inhibitors are refractory to development of resistance

Paola Favuzza, Madeline G. Dans, Wenyin Su, Jennifer K. Thompson, Anthony N. Hodder, Anna Ngo, Jocelyn Sietsma Penington, Danushka S. Marapana, Jerzy M. Dziekan, Anthony T. Papenfuss, Manuel de Lera Ruiz, Rachael Coyle, Marcus C. S. Lee, John A. McCauley, Kym Lowes, David B. Olsen, Brad E. Sleebs, Alan F. Cowman

PLOS Pathogens: published September 8, 2026 | https://doi.org/10.1371/journal.ppat.1014068

IL-22 promotes the establishment of chronic gammaherpesvirus infection by supporting the germinal center response

Sheikh Tahir Majeed, Samantha M. Bradford, Christopher N. Jondle

PLOS Pathogens: published September 8, 2026 | https://doi.org/10.1371/journal.ppat.1014016

TKL3 regulates blood-stage fitness, male gamete fertility, and transmission-stage development in Plasmodium berghei

Himadri Shukla, Nirdosh, Satish Mishra

PLOS Pathogens: published September 8, 2026 | https://doi.org/10.1371/journal.ppat.1014582

TRIM21 blocks DDX3X-driven stress granule formation during Mycobacterium tuberculosis infection via a non-canonical E3 ligase mechanism

Ruiyao Xu, Mengru Lu, Gaoyan Wang, Ximeng Zhang, Yuxing Huang, Yu Wang, Qing Yu, Yaxuan Wang, Dan Chen, Yunlong Hu, Chenyan Shi, Yi Cai, Li Fu, Xinchun Chen, Youchao Dai

PLOS Pathogens: published September 8, 2026 | https://doi.org/10.1371/journal.ppat.1014553

Structure of NO16, a marine non-tailed vibriophage with an unusual symmetry-mismatched vertex arrangement

Sara Otaegi-Ugartemendia, Gabriela N. Condezo, Marta Martínez, Panos G. Kalatzis, Mathias Middelboe, Carmen San Martín

PLOS Pathogens: published September 8, 2026 | https://doi.org/10.1371/journal.ppat.1014525

Transposon insertion sequencing of Pseudomonas aeruginosa identifies multiple intersecting pathways essential for extreme colistin resistance

Madeleine B. Vessely, Ryan P. Kich, Samuel W. M. Gatesy, Hanna K. Bertucci, Aliki Valdes, Clara Luczak, Shradha Rao, Artur Muszyński, Parastoo Azadi, Casey N. Kellogg, Brandon L. Jutras, John Mekalanos, Alan R. Hauser, Egon A. Ozer, Kelly E. R. Bachta

PLOS Pathogens: published September 8, 2026 | https://doi.org/10.1371/journal.ppat.1014168

Epigenetic profiling reveals M1 macrophages as the primary drivers of trained immunity in HSV-1 latently infected mice

Ujjaldeep Jaggi, Shaohui Wang, Homayon Ghiasi

PLOS Pathogens: published September 9, 2026 | https://doi.org/10.1371/journal.ppat.1014598

Updated A(H1N1)pdm09 influenza virus ferret infection model permits refined antiviral assessment using aerosol inhalation challenge

Harry L. Stannard, Nicole Brock, Xiangjie Sun, Joanna A. Pulit-Penaloza, Troy J. Kieran, Ashwin Muraleetharan, Clyde Dapat, Smitha Rose Georgy, Taronna R. Maines, Ian G. Barr, Patrick C. Reading, Saira Hussain, Jessica A. Belser

PLOS Pathogens: published September 9, 2026 | https://doi.org/10.1371/journal.ppat.1014604

Conserved assembly architecture of the essential herpesvirus packaging accessory factor

Elizabeth J. Bailey, Swapnil C. Devarkar, Renata Szczepaniak, Laura M. Meißner, Xinyu Chen, Chunxiang Wu, Sandra K. Weller, Yong Xiong, Allison L. Didychuk

PLOS Pathogens: published September 10, 2026 | https://doi.org/10.1371/journal.ppat.1014540

Longitudinal assessment of functional antibodies to a novel influenza virus strain across age groups

Anke Huckriede, Ilse Hoorn, Manas Joshi, Jacqueline de Vries-Idema, Gestur Vidarsson, Puck B. van Kasteren, Martin Beukema

PLOS Pathogens: published September 10, 2026 | https://doi.org/10.1371/journal.ppat.1014014

African swine fever virus impairs porcine alveolar macrophages bactericidal function by disrupting lysosomal acidification and cathepsin activity

Zhen Xu, Fengyang Shi, Zhiyong Xiang, Runzhi Guo, Zhenyu Wen, Yajin Qu, Quanlin Li, Qiongqiong Zhou, Peng Gao, Yongning Zhang, Xinna Ge, Jun Han, Xin Guo, Lei Zhou, Hanchun Yang

PLOS Pathogens: published September 10, 2026 | https://doi.org/10.1371/journal.ppat.1014573

Usutu virus promotes West Nile virus replication in Culex pipiens biotype molestus during simultaneous and sequential co-infections

Christin Körsten, Cornelia Silaghi, Mandy Schäfer

PLOS Pathogens: published September 11, 2026 | https://doi.org/10.1371/journal.ppat.1014601

Small molecule inhibition of the mitochondrial lipid transfer protein STARD7 attenuates influenza viral replication

Shipra Sharma, Oyahida Khatun, Jihaan Adonis, Shaochen You, Kevin Hartenbower, Vedita Anand Singh, Namir Shaabani, Saikat De, Emi R. Matsuo, Rachel Y. Sattler, Jonathan A. Covel, Kris M. White, Laura Martin-Sancho, Malina A. Bakowski, Dylan J. Mendonsa, Ayush Mehta, Noura S. Yassir, Steven H. Olson, Naoko Matsunaga, Adolfo García-Sastre, Michael J. Bollong, Nisar A. Farhat, Megan L. Shaw, Sumit K. Chanda

PLOS Pathogens: published September 11, 2026 | https://doi.org/10.1371/journal.ppat.1013914

Discovering host-viral protein interactions in autophagy: A LIR discovery pipeline for identifying LC3-interacting region motifs in highly virulent viruses

Kaylee D. Petraccione, Haytham M. Wahba, Mohamed G. H. Ali, Timothy Stocker, Ivan Akhrymuk, Yossira Swese, Danuta Sastre, Andrew Silberfarb, Paul E. O’Maille, James G. Omichinski, Kylene Kehn-Hall

PLOS Pathogens: published September 11, 2026 | https://doi.org/10.1371/journal.ppat.1014607

Resistance breaking Root-knot nematodes carry a fitness cost associated with defective feeding site development

Alison C. Blundell, Emma Shigekane-Kraft, Sławomir Janakowski, Mirosław Sobczak, Dadong Dai, Yali Zhang, Pallavi Shakya, Ching-Jung Lin, Valerie M. Williamson, Shahid Siddique

PLOS Pathogens: published September 11, 2026 | https://doi.org/10.1371/journal.ppat.1014581

The Edwardsiella T3SS effector EseJ enhances NF-κB signaling by stabilizing p65 and promoting TAK1 phosphorylation

Tian Tian He, Pu Yu Tang, Qian Ru Zhao, Jie Zhang, Pin Nie, Hong Bing Yu, Hai Xia Xie

PLOS Pathogens: published September 15, 2026 | https://doi.org/10.1371/journal.ppat.1014260

Epstein-Barr virus-encoded microRNA-BART17-5p suppresses cell proliferation and metastasis by targeting CERK

Peilin Wu, Xiazhen Xu, Qiong Wu, Lu Zhang, Fan Xin, Xiaowei Zheng, Xu Lin, Wannan Chen

PLOS Pathogens: published September 15, 2026 | https://doi.org/10.1371/journal.ppat.1014519

Genomic epidemiology of coxsackievirus A24 variant during the 2024 acute hemorrhagic conjunctivitis outbreak in Coastal Kenya

John Mwita Morobe, Edidah M. Ong’era, Arnold W. Lambisia, Samuel O. Odoyo, Martin Mutunga, Esther N. Katama, Robinson Cheruiyot, Joyce U. Nyiro, Everlyn Kamau, Charlotte J. Houldcroft, Matt Keeling, Katherine Gallagher, Edward C. Holmes, Charles N. Agoti

PLOS Pathogens: published September 15, 2026 | https://doi.org/10.1371/journal.ppat.1014589

Dual regulation of the receptor-like kinase BIR1 involves site-directed transcript cleavage and 5’-leader-mediated translational control

Irene Guzmán-Benito, Carmen Robinson, Livia Donaire, Lourdes Fernández-Calvino, José Manuel Franco-Zorrilla, Ruixia Niu, Guoyong Xu, Catharina Merchante, César Llave

PLOS Pathogens: published September 15, 2026 | https://doi.org/10.1371/journal.ppat.1014571

FgNup2 regulates nuclear import of the histone H2B monoubiquitination enzyme by stabilizing the FgImpα-FgBre1 complex to mediate pathogenicity in Fusarium graminearum

Yaxuan Wang, Zhe Li, Xiaoyan Wang, Bin Xiong, Chengqi Zhang, Xiaozhen Zhao, Shentao Wang, Li Chen

PLOS Pathogens: published September 15, 2026 | https://doi.org/10.1371/journal.ppat.1014577

Polymicrobial-driven NLRP6 inflammasome regulates IL-1β production and alveolar bone loss in a murine model of periodontitis

Sarah Metcalfe, Rajendra P. Settem, Edwin J. Ovalle, Michelle Panasiewicz, Alejandro Escobar, Jason G. Kay

PLOS Pathogens: published September 15, 2026 | https://doi.org/10.1371/journal.ppat.1014574

Coronavirus Nsp5‑mediated dual‑site cleavage of GSDMA modifies its antiviral and proinflammatory functions

Chenyu Li, Yuxi Zhao, Yuchen Zhang, Shuai Li, Longfei Chen, Xiangfei Xu, Tong Ding, Yuanqing Wang, Xiang Gao, Zhaoyu Lin, Guanning Su, Ankang Hu, Liurong Fang, Qi Su, Quangang Chen, Yanrong Zhou, Shaobo Xiao

PLOS Pathogens: published September 16, 2026 | https://doi.org/10.1371/journal.ppat.1014602

Discovery of repurposed drugs that disrupt intracellular replication of Burkholderia pseudomallei and Burkholderia mallei and protect against lethal aerosol infection

Nichole Orr-Burks, Sarah R. Hosking, Steven P. Maher, Dennis E. Kyle, Malina A. Bakowski, Robert J. Hogan, Eric R. Lafontaine

PLOS Pathogens: published September 16, 2026 | https://doi.org/10.1371/journal.ppat.1014596

Analysis of host and viral nascent and steady-state RNA levels in a human neuronal model of herpes simplex virus 1 infection

Claire H. Birkenheuer, Terri G. Edwards, David C. Bloom, Joel D. Baines

PLOS Pathogens: published September 16, 2026 | https://doi.org/10.1371/journal.ppat.1014603

Biophysical and functional characterization of the Escherichia coli Dr fimbrial envelope reveals its importance for pathogenesis and lithogenesis

Michalina Nagórka, Beata Zalewska-Piątek, Adam Iwanicki, Paweł Wityk, Slawomir Jakiela, Weronika Switlik, Piotr Bruździak, Miłosz Wieczór, Vanessa Liévin-Le Moal, Joanna Raczak-Gutknecht, Przemysław Gnatowski, Mateusz Ficek, Angelika Łepek, Magdalena Narajczyk, Rafał Piątek

PLOS Pathogens: published September 16, 2026 | https://doi.org/10.1371/journal.ppat.1014588

Evidence for multiple prion conformers in natural scrapie isolates

Morikazu Imamura, Kohtaro Miyazawa, Hiroyuki Okada, Minako Ohno, Hiromi Iguchi, Yuichi Matsuura, Yoshifumi Iwamaru, Hanae Takatsuki, Tsuyoshi Mori, Jiyan Ma, Ryuichiro Atarashi

PLOS Pathogens: published September 17, 2026 | https://doi.org/10.1371/journal.ppat.1014283

Two domesticated species of rice shaped the population structure of Xanthomonas oryzae pv. oryzae in Africa

Ian Lorenzo Quibod, Coline Sciallano, Florence Auguy, Laurent Brottier, Alexis Dereeper, Diariatou Diagne, Amadou Diallo, Hinda Doucouré, Solely Issaka Mayaki, Ibrahim Keita, Lazeni Konate, Hamidou Tall, Cheick Tékété, Sylvain Zougrana, Mathilde Hutin, Ousmane Koita, Daoudou Kone, Soungalo Sarra, Valérie Verdier, Issa Wonni, Boris Szurek, Sébastien Cunnac, Alvaro L. Pérez-Quintero

PLOS Pathogens: published September 17, 2026 | https://doi.org/10.1371/journal.ppat.1014015

A feline coronavirus nucleocapsid protein disrupts ZC3HAV1–viral RNA association to counteract host RNA-level restriction

Miao Zhang, Na Li, Kelimujiang Aishanjiang, Aoxing Tang, Meng Zhu, Shiqiang Zhu, Da Zhang, Lingxue Yu, Jie Zhu, Chuanfeng Li, Chunchun Meng, Yingqi Zhu, Guoxin Li, Guangqing Liu

PLOS Pathogens: published September 18, 2026 | https://doi.org/10.1371/journal.ppat.1014616

Grass carp reovirus activates fish Ppp1r3g to suppress innate immunity and exacerbate hemorrhage via the 14-3-3ζ/Itgb3 signaling axis

Ruyi Wang, Man Zhou, Yuxuan Wang, Xudong Hu, Han Zhang, Hong Cao

PLOS Pathogens: published September 18, 2026 | https://doi.org/10.1371/journal.ppat.1014590

Ubiquitylation by the GID/CTLH complex regulates the metabolic and innate immune response of macrophages to infection by Mycobacterium tuberculosis

Nelson V. Simwela, Luana Johnston, Christopher M. Sassetti, David G. Russell

PLOS Pathogens: published September 18, 2026 | https://doi.org/10.1371/journal.ppat.1014196

The impact of TcdB conformational dynamics on vaccination against Clostridioides difficile

Megan L. Kempher, Tyler M. Shadid, Gillian A. Lang, Sydney T. Honold, Jordan N. May, Elizabeth J. Hall, Jason L. Larabee, Mark L. Lang, Jimmy D. Ballard

PLOS Pathogens: published September 18, 2026 | https://doi.org/10.1371/journal.ppat.1014627

Tac1 deficiency reduces the severity of enteric bacterial infection

Elliot Lloyd, Michael Cremin, Emmy Tay, Kristina Sanchez, Jungjae Park, YuanYuan Lei, Melanie G. Gareau, Colin Reardon

PLOS Pathogens: published September 18, 2026 | https://doi.org/10.1371/journal.ppat.1014587

The insect- and plant-associated lifestyles of Pseudomonas protegens CHA0 are preserved following serial passage through insect larvae

Maria Zwyssig, Jana Schneider, Gijs Selten, Christoph Keel, Monika Maurhofer, Ronnie de Jonge

PLOS Pathogens: published September 21, 2026 | https://doi.org/10.1371/journal.ppat.1014101

The pod components of the Shigella T3SS sorting platform accommodate multiple copies of Spa33 (SctQ)

Sean K. Whittier, Shoichi Tachiyama, Samira Heydari, Wendy L. Picking, Jun Liu, William D. Picking

PLOS Pathogens: published September 21, 2026 | https://doi.org/10.1371/journal.ppat.1014592

Small impact of the host plant physiological state on the genome formula of a nanovirus

Mélia Bonnamy, Andy Brousse, Prune Lacôte Popovic, Yannis Michalakis, Stéphane Blanc

PLOS Pathogens: published September 21, 2026 | https://doi.org/10.1371/journal.ppat.1014641

Phosphorylated HPV‑16 E7 disrupts planar cell polarity in cervical cancer cells through vangl1 dysregulation

Ifeoluwa D. Gbala, Om Basukala, Amira Zine El Abidine, Michael P. Myers, Rebecca Bertolio, Giannino Del Sal, Lawrence Banks

PLOS Pathogens: published September 21, 2026 | https://doi.org/10.1371/journal.ppat.1014555

A single-cycle, recombinant VSV platform Nipah vaccine cross-protects against Hendra virus in nonhuman primates

Declan D. Pigeaud, Viktoriya Borisevich, Jacquelyn Turcinovic, Krystle N. Agans, Daniel J. Deer, Mack B. Harrison, Rachel O’Toole, Natalie S. Dobias, Abhishek N. Prasad, Karla A. Fenton, Robert W. Cross, Thomas W. Geisbert

PLOS Pathogens: published September 22, 2026 | https://doi.org/10.1371/journal.ppat.1014646

Transposon-insertion sequencing reveals NlpD as a vulnerability in intracellular survival and pathogenesis of Salmonella 4,[5],12:i:-

Mengping He, Jinju Cai, Huihui Wu, Tianqi Xu, Haijie Zhang, Zhiqiang Wang, Yuan Liu

PLOS Pathogens: published September 22, 2026 | https://doi.org/10.1371/journal.ppat.1014640

Role of PRMT5 in regulating ferritinophagy during Mycobacterium tuberculosis infection

Smriti Sundar, Raju S. Rajmani, Kithiganahalli Narayanaswamy Balaji

PLOS Pathogens: published September 22, 2026 | https://doi.org/10.1371/journal.ppat.1014614

Host-directed clearance of nuclear tegument U14 terminates NF-κB signaling and supports HHV-6A replication

Khoir Amaliin, Mansaku Hirai, Salma Aktar, Tetsuo Koshizuka, Yasuko Mori, Jun Arii

PLOS Pathogens: published September 23, 2026 | https://doi.org/10.1371/journal.ppat.1014576

SARS-CoV-2 defective viral genomes from distinct genomic regions drive divergent interferon responses

Justin W. Brennan, Simone Spandau, Jiayu Xu, Xingjian Wang, Haley Aull, Gaochan Wang, Sarah Connor, Gloria S. Pryhuber, Thomas J. Mariani, Ruth Serra-Moreno, Susan R. Weiss, Yan Sun

PLOS Pathogens: published September 23, 2026 | https://doi.org/10.1371/journal.ppat.1014099

Transcriptional architecture of African swine fever virus

Guiqian Wang, Pengfei Li, Xinglin He, Hua Cao, Ahmed H. Ghonaim, Shengnan Ruan, Xuexiang Yu, Jiaru Zhou, Hongmei Zhu, Mengjia Zhang, Anan Jongkaewwattana, Guiqing Peng, Qigai He, Wentao Li

PLOS Pathogens: published September 23, 2026 | https://doi.org/10.1371/journal.ppat.1014617

The translatome of quiescent Plasmodium falciparum gametocytes reveals parasite pyridoxal 5’-phosphate (PLP) biosynthesis is essential for efficient mosquito stage development

Eduardo Alves, Jack W. Houghton, Lindsay B. Stewart, Mufuliat T. Famodimu, Rosie Bridgwater, Mariana Reis Wunderlich, Naoki Matoba, Annie Z. Tremp, Michaela Bikarova, Jianan Lu, Mojca Kristan, Colin J. Sutherland, Edward W. Tate, Michael J. Delves

PLOS Pathogens: published September 23, 2026 | https://doi.org/10.1371/journal.ppat.1014635

Metabolic cooperation supports mutual growth between the protozoan parasite Trichomonas vaginalis and dysbiotic vaginal bacteria

Annabel S. Hinderfeld, Raphael Bang, Bailey S. Dickson, Saif Faraj, Augusto Simoes-Barbosa

PLOS Pathogens: published September 23, 2026 | https://doi.org/10.1371/journal.ppat.1014620

Functional divergence of the Bhanja virus NSs protein modulates interferon antagonism and viral fitness across divergent lineages

Andrew T. Clarke, Kelsey Davies, Mazigh Fares, Agnieszka M. Szemiel, Diogo Correa Mendonca, Karen Kerr, Vanessa Herder, Lesley Bell-Sakyi, Brian J. Willett, Arvind H. Patel, Alain Kohl, Benjamin Brennan

PLOS Pathogens: published September 24, 2026 | https://doi.org/10.1371/journal.ppat.1014645

GM000287 is a conserved determinant of serum resistance and virulence in Klebsiella pneumoniae

Xiaomin Lin, Junjun Jia, Zilin Zhuang, Yixin Mo, Xiaoxin Pan, Kaining Zhong, Ping Shen, Quanjiang Ji, Kai Zhou, Liang Yang, Yonghong Xiao, Chunfu Yang

PLOS Pathogens: published September 24, 2026 | https://doi.org/10.1371/journal.ppat.1014619

Serine protease inhibitor from Trichinella spiralis ameliorates diet-induced obesity and adipose tissue inflammation through TIM-3-dependent macrophage reprogramming

Mingwei Tong, Ge Liu, Guidong Ren, Wangxuan Zhang, Yuyu Qiao, Xiaodan Yang, Weiping Fan, Hui Yang, Yong Yang

PLOS Pathogens: published September 25, 2026 | https://doi.org/10.1371/journal.ppat.1014606

NSUN2-mediated m5C modification of HIV-1 RNA enables evasion of RIG‑I‑dependent innate immunity

Yuebo Xu, Mingyang Li, Yingying Song, Weili Kong, Jingjing Song, Jiali Zhang, Xinmu Xu, Haoyu Ma, Shun Yu, Shuliang Chen, Cong Zeng

PLOS Pathogens: published September 25, 2026 | https://doi.org/10.1371/journal.ppat.1014611

Targeted lysosomal activation in bladder epithelium enhances clearance of intracellular uropathogenic Escherichia coli

Kathrin Tomasek, Kristina Skurvydaite, Gauri Paduthol, Allison M. Burns, Léa Schlunke, Valentin Borgeat, Christian Pasquali, Mario Romani, John D. McKinney

PLOS Pathogens: published September 25, 2026 | https://doi.org/10.1371/journal.ppat.1014448

A bacterial pangenome association study identifies a role for polyamine metabolism and alkaline tolerance in middle ear infections

Jocelyn A. Hammond, Rachel L. Ehrlich, Ariel Gonzalez, Begoña Euba, Kevin M. Raible, Jill M. Lawrence, Ari B. Gordon, Evangeline Williams, Mary C. Marino, Jason Limbo, Steven Lang, Bhaswati Sen, Sergey V. Balashov, Azad Ahmed, Junkal Garmendia, Joris Beld, Garth D. Ehrlich, Michael E. Pichichero, Ravinder Kaur, Joshua Chang Mell

PLOS Pathogens: published September 25, 2026 | https://doi.org/10.1371/journal.ppat.1014649

PfATG18 links V-ATPase assembly to endocytic membrane dynamics in malaria parasites

Yasmin Schmitz, Moumita Sengupta, Carola Schneider, Tanja Ziesmann, Franziska Hellmold, Ute Distler, Rudolph Reimer, Joachim Michael Matz

PLOS Pathogens: published September 28, 2026 | https://doi.org/10.1371/journal.ppat.1014608

Hijacking of host PCNA by circovirus replication-associated protein to recruit POLD1 drives viral DNA replication and is inhibited by R428

Lei Zhu, Guan Zhang, Yingying Pu, Wenyu Wang, Zhanyan Zhang, Jiasai Kang, Haoshu Zhang, Lingling Chang, Le Shi, Yong Huang, Dewen Tong, Qian Du

PLOS Pathogens: published September 28, 2026 | https://doi.org/10.1371/journal.ppat.1014575

Palmitoylation of glycoproteins under low temperature enhances SVCV replication

Chen Li, Yan Zhang, Yujun Zhang, Yan Gao, Yuanan Lu, Shengbo Cao, Jing Ye, Xueqin Liu

PLOS Pathogens: published September 28, 2026 | https://doi.org/10.1371/journal.ppat.1014654

Spotted fever group Rickettsia infection kinetics and cutaneous host response during single tick feeding events

Chanakan Suwanbongkot, Ingeborg M. Langohr, Killian Z. Brewer, Robert A. Barrington, Kevin R. Macaluso

PLOS Pathogens: published September 28, 2026 | https://doi.org/10.1371/journal.ppat.1014626

Proteome-wide characterization of Plasmodium vivax antigens using a high-density peptide array

Rosita Asawa, Brittany Hazzard, Katie Ko, Kieran Tebben, John Tan, Tineke Cantaert, Andrea Berry, Niraj Tolia, Jean Popovici, David Serre

PLOS Pathogens: published September 28, 2026 | https://doi.org/10.1371/journal.ppat.1014621

Complexome profiling of mitochondria in the myzozoan parasite of oysters, Perkinsus marinus

Andrew E. Maclean, Orsola Iorillo, Drahomíra Faktorová, Monika Singh, Suzanne McGill, Julius Lukeš, Lilach Sheiner

PLOS Pathogens: published September 29, 2026 | https://doi.org/10.1371/journal.ppat.1014543

A fish-specific E3 ubiquitin ligase NHRE3 suppresses antiviral immunity by degrading ISG15 via ubiquitination

Juhong Xie, Jiayi Lei, Qinxue Zhu, Bin Gui, Yongming Li, Yaping Wang, Rong Huang

PLOS Pathogens: published September 29, 2026 | https://doi.org/10.1371/journal.ppat.1014544

Metabolic regulation of the carbonyl stress pathway and methylglyoxal in Lyme disease and relapsing fever spirochetes

Dan Drecktrah, Laura S. Hall, Britney Cheff, Crystal Richards, Sandra J. Raffel, Michael Wulf, Ian T. Bailey, Frank Gherardini, D. Scott Samuels

PLOS Pathogens: published September 29, 2026 | https://doi.org/10.1371/journal.ppat.1014657

Sph-mediated mtDNA release and autophagy-dependent ferroptosis contribute to Staphylococcus aureus-induced mastitis

Yunfei Wei, Xinyu Zhao, Ziyi Yin, Yanmin Zhang, Yaxin Zhai, Baihe Zhan, Yeling Wang, Jiakang He, Jianfeng Wang, Xuming Deng, Lei Xu, Haihua Feng

PLOS Pathogens: published September 29, 2026 | https://doi.org/10.1371/journal.ppat.1014644

Immunopeptidomics reveals conserved and abundant Francisella tularensis proteins as immunogenic CD4 T cell antigens in mice

Pavlina Laskova, Stanislava Porkertova, Ondrej Ballek, Lucie Balonova, Jana Pavloskova, Ales Neuwirth, Ivona Pavkova, Ivo Fabrik, Pavol Lukac, Luca Vannucci, Dominik Filipp, Jiri Stulik, Marek Link

PLOS Pathogens: published September 29, 2026 | https://doi.org/10.1371/journal.ppat.1014597

Elevated Plasmodium falciparum sexual conversion in HbAC and HbAS red blood cells in naturally infected malaria patients

Yasmina Drissi-El Boukili, Vera Kühne, H. Magloire Natama, Pieter Moris, Elisabet Tintó-Font, Antonia Windkouni Bere, Odin Goovaerts, Pieter Guetens, Ana Moreno-Murillo, Yarno Valgaerts, T. Edwig Traoré, D. Florence Ouedraogo, Halidou Tinto, Ann Van de Velde, Alfred Cortés, Guy Caljon, Anna Rosanas-Urgell

PLOS Pathogens: published September 29, 2026 | https://doi.org/10.1371/journal.ppat.1014542

Epithelial interferon-γ responsiveness shapes chemokine induction and clinical outcomes in herpes simplex virus infection

Angelina Zimenko, Ian Hayman, Youyi Fong, Luke D. Monroe, Margaret G. Mills, Alex Greninger, Christine Johnston, Lawrence Corey, Jia Zhu

PLOS Pathogens: published September 30, 2026 | https://doi.org/10.1371/journal.ppat.1014612

Correction: Noncanonical bactericidal activity of teleost type I interferon is conferred by a membrane-targeting C-terminal peptide

Han Zhang, Ying Wu, Xiaoyuan Zheng, Ziyu Wang, Chen Zhang, Zhenjie Cao, Jingqun Ao, Yongcan Zhou, Yun Sun

PLOS Pathogens: published September 3, 2026 | https://doi.org/10.1371/journal.ppat.1014570

Related Articles

1. Noncanonical bactericidal activity of teleost type I interferon is conferred by a membrane-targeting C-terminal peptide

Correction: Immune-focused RBD nanoparticles induce cross-reactive, RBS-directed responses capable of variant-resistant SARS-CoV-2 neutralization

Kylie M. Konrath, Kevin Liaw, Nicholas J. Tursi, Madison E. McCanna, Bryce M. Warner, Ebony N. Gary, Xizhou Zhu, Cory Livingston, Cara Monastra, Drew Frase, Neethu Chokkalingam, Alana Huynh, Nicholas Shupin, Kelly Bayruns, Sinja Kriete, Amber Kim, Joyce Park, Robert Vendramelli, Thang Truong, Kevin Tierney, Kimberly Azaransky, Estella Moffat, Carissa Embury-Hyatt, Lynn A. Beer, Oreoluwa Solanke, Susanne N. Walker, Richa Kalia, Hsin-Yao Tang, Laurent M. P. F. Humeau, Trevor R. F. Smith, Darwyn Kobasa, David B. Weiner, Daniel W. Kulp

PLOS Pathogens: published September 14, 2026 | https://doi.org/10.1371/journal.ppat.1014593

Related Articles

1. Immune-focused RBD nanoparticles induce cross-reactive, RBS-directed responses capable of variant-resistant SARS-CoV-2 neutralization

Correction: Extended poly(A) tails are a shared feature of herpesvirus mRNAs

Erik Fuhrmann, Sae Toda, Jonas Leins, Pierina Cetraro, Vedang Deshpande, Jasmine Rowell, Edward A. Chapman, Carina Jacobsen, Kai A. Kropp, Mart M. Lamers, Elene Loliashvili, Mostafa Saleban, Ruth Verstraten, Carolin Vogt, Wiyada Wongwiwat, Werner J. D. Ouwendijk, Abel Viejo-Borbolla, Robert E. White, Angus C. Wilson, Hannah M. Burgess, Daniel P. Depledge

PLOS Pathogens: published September 14, 2026 | https://doi.org/10.1371/journal.ppat.1014584

Related Articles

1. Extended poly(A) tails are a shared feature of herpesvirus mRNAs

Correction: Ultrapotent neutralization of Bacillus anthracis toxin by a human antibody via blockade of PA oligomerization

Qi Wang, Ting Fang, Zhenwei Song, Xiaoyan Huang, Sijun He, Tianfu Li, Jianmin Li, Xiangyang Chi, Pengfei Fan, Changming Yu

PLOS Pathogens: published September 15, 2026 | https://doi.org/10.1371/journal.ppat.1014594

Related Articles

1. Ultrapotent neutralization of Bacillus anthracis toxin by a human antibody via blockade of PA oligomerization

Correction: Directed evolution of a stem-helix–targeting antibody enables MERS-CoV cross-neutralization through enhanced binding affinity

The PLOS Pathogens Staff

PLOS Pathogens: published September 28, 2026 | https://doi.org/10.1371/journal.ppat.1014636

Related Articles

1. Directed evolution of a stem-helix–targeting antibody enables MERS-CoV cross-neutralization through enhanced binding affinity

Retraction: Japanese encephalitis virus orchestrates GLUT4-mediated glucose metabolism to potentiate viral replication via insulin receptor signaling

The PLOS Pathogens Editors

PLOS Pathogens: published September 21, 2026 | https://doi.org/10.1371/journal.ppat.1014600

Related Articles

1. RETRACTED: Japanese encephalitis virus orchestrates GLUT4-mediated glucose metabolism to potentiate viral replication via insulin receptor signaling

Formal Comment on “Platelet-leucocyte interactions drive MMP-mediated tissue damage in tuberculosis” (Kirwan et al., 2026)

Qingqing Shan

PLOS Pathogens: published September 24, 2026 | https://doi.org/10.1371/journal.ppat.1014628

Related Articles

1. Platelet-leucocyte interactions drive MMP-mediated tissue damage in tuberculosis

EspO-mediated neutrophil accumulation drives lethality during Citrobacter rodentium infection in interleukin-22-deficient mice

Vishwas Mishra, Priyanka Biswas, Zuza Kozik, Jyoti Choudhary, Gad Frankel

PLOS Pathogens: published September 2, 2026 | https://doi.org/10.1371/journal.ppat.1014567