Skip to main content
Springer Nature Link
Log in
Menu
Find a journal Publish with us Track your research
Search
Saved research
Cart
  1. Home
  2. Mammalian Genome
  3. Article

Isolation, physical mapping, and Northern analysis of the X-linked human gene encoding methyl CpG-binding protein, MECP2

  • Original Contribution
  • Published: July 1996
  • Volume 7, pages 533–535 (1996)
  • Cite this article

Access provided by Institution of Civil Engineers Library

Download PDF
Save article
View saved research
Mammalian Genome Aims and scope Submit manuscript
Isolation, physical mapping, and Northern analysis of the X-linked human gene encoding methyl CpG-binding protein, MECP2
Download PDF
  • M. D’Esposito1,
  • N. A. Quaderi3,
  • A. Ciccodicola1,2,
  • P. Bruni1,
  • T. Esposito1,2,
  • M. D’Urso1 &
  • …
  • S. D. M. Brown3 
  • 447 Accesses

  • 98 Citations

  • 3 Altmetric

  • Explore all metrics

Article PDF

Download to read the full article text

Explore related subjects

Discover the latest articles, books and news in related subjects, suggested using machine learning.
  • Alternative Splicing Mechanisms in Cancer Biology

References

  • Adler, D.A., Quaderi, N.A., Brown, S.D.M., Chapman, V.M., Moore, J., Tate, P., Disteche, C. (1995). The X-linked methylated DNA binding protein, Mecp2, is subject to X inactivation in mouse. Mamm. Genome, 6, 491–492.

    Article  CAS  Google Scholar 

  • Blanchard, M.M., Taillon-Miller, P., Novotny, P., Novotny, W. (1993). PCR buffer optimization with uniform temperature regimen to facilitate automation. PCR Methods Appl. 2, 234–240.

    PubMed  CAS  Google Scholar 

  • Brown, C.J., Flenniken, A.M., Williams, B.R.G., Willard, H.F. (1990. X chromosome inactivation of the human TIMP gene. Nucleic Acids Res. 18,4191–4195.

    Article  PubMed  CAS  Google Scholar 

  • Brown, C.J., Ballabio, A., Rupert, J.L., Lafreniere, R.G., Grompe, M., Tonlorenzi, R., Willard, H.F. (1991). A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature 349, 38–44.

    Article  PubMed  CAS  Google Scholar 

  • Brown, S.D.M., Avner, P., Boyd, Y., Chapman, V., Rastan, S., Sefton, L., Thomas, J.D., Herman, G.E. (1993). Mouse X chromosome. Mamm. Genome 4(Suppl.), S269-S281.

    CAS  Google Scholar 

  • Davies, K.E., Mandel, J.L., Monaco, A.P., Nussbaum, R.L., Willard, H.F. (1992). Report of the committee on the genetic constitution of the X chromosome. Cytogenet. Cell Genet. 58, 1–117.

    Article  Google Scholar 

  • Dietrich, A., Korn, B., Poutska, A. (1992). Completion of the physical map of Xq28: the location of the gene for LI CAM on the human X chromosome. Mamm. Genome 3, 168–172.

    CAS  Google Scholar 

  • Kaneko, K., Warren, S.T., Miyatake, T., Tsuji, S. (1993) Isolation of 353 Not I linking clones and 62 DNA markers (DXS607-DXS668) from human chromosome Xq24-qter. Cytogenet. Cell Genet. 64, 5–8.

    Article  PubMed  CAS  Google Scholar 

  • Levinson, B., Kenwrick, S., Lakich, D., Hammonds, G., Gitschier, J. (1990). A transcribed gene in an intron of the human factor VIII gene. Genomics 7, 1–11.

    Article  PubMed  CAS  Google Scholar 

  • Levinson, B., Bermingham, J.R., Metzenberg, A., Kenwrick, S., Chapman, V., Gitschier, J. (1992). Sequence of the factor VIII-associated gene is conserved in mouse. Genomics 13, 862–865.

    Article  PubMed  CAS  Google Scholar 

  • Lewis, J.D., Meehan, R.R., Henzel, W.J., Maurer-Fogy, I., Jeppesen, P., Klein, F., Bird, A.P. (1992). Purification, sequence and cellular localisation of a novel chromosomal protein that binds to methylated DNA. Cell 69, 905–914.

    Article  PubMed  CAS  Google Scholar 

  • Li, E., Bester, T.H., Jaenisch, R. (1992). Targeted mutation of the DNA methyltransferase gene results in embryonic lethality. Cell 69, 915–926.

    Article  PubMed  CAS  Google Scholar 

  • Meehan, R.R., Lewis, J.D., McKay, S., Kleiner, E.L., Bird, A.P. (1989). Identification of a mammalian protein that binds specifically to DNA that contains methylated CpGs. Cell 58, 499–507.

    Article  PubMed  CAS  Google Scholar 

  • Meehan, R.R., Lewis, J.D., Bird, A.P. (1992a). Characterisation of MeCP2, a vertebrate DNA binding protein with affinity for methylated DNA. Nucleic Acids Res. 20, 5085–5092.

    Article  PubMed  CAS  Google Scholar 

  • Meehan, R.R., Lewis, J.D., Cross, S.H., Nan, X., Jeppesen, P., Bird, A.P. (1992b). Transcriptional repression by methylation of CpG. J. Cell sci. 16, 9–14.

    CAS  Google Scholar 

  • Nan, X., Meehan, R.R., Bird, A.P. (1993). Dissection of the methyl-CpG binding domain from the chromosomal protein MeCP2. Nucleic Acids Res. 21, 4886–4892.

    Article  PubMed  CAS  Google Scholar 

  • Palmieri, G., Romano, G., Ciccodicola, A., Casamassimi, A., Campanile, C, Esposito, T., Cappa, V., Lania, A., Johnson, S., Reinbold, R., Poutska, A., Schlessinger, D., D’;Urso, M. (1994). YAC contig organisation and CpG island analysis in Xq28. Genomics 24, 149–158.

    Article  PubMed  CAS  Google Scholar 

  • Quaderi, N.A., Meehan, R.R., Tate, P.H., Cross, S.H., Bird, A.P., Chatterjee, A., Herman, G.E., Brown, S.D.M. (1994). Genetic and physical mapping of a gene encoding a methyl CpG binding protein, Mecp2, to the mouse X chromosome. Genomics 22, 648–651.

    Article  PubMed  CAS  Google Scholar 

  • Tate, P., Skarnes, W., Bird, A. (1996). The methyl-CpG binding protein MeCP2 is essential for embryonic development in the mouse. Nature Genet. 12, 205–208.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. International Institute of Genetics and Biophysics, CNR, Via Marconi 10, 1-80125, Naples, Italy

    M. D’Esposito, A. Ciccodicola, P. Bruni, T. Esposito & M. D’Urso

  2. Sezione di Istologia-Embriologia e Genetica, Dipartimento di Scienze Morfologiche e Medico-Legali, University of Modena, Italy

    A. Ciccodicola & T. Esposito

  3. Department of Biochemistry and Molecular Genetics, St. Mary’s Hospital Medical School, Imperial College of Science, Technology and Medicine, Norfolk Place, W21PG, London, UK

    N. A. Quaderi & S. D. M. Brown

Authors
  1. M. D’Esposito
    View author publications

    Search author on:PubMed Google Scholar

  2. N. A. Quaderi
    View author publications

    Search author on:PubMed Google Scholar

  3. A. Ciccodicola
    View author publications

    Search author on:PubMed Google Scholar

  4. P. Bruni
    View author publications

    Search author on:PubMed Google Scholar

  5. T. Esposito
    View author publications

    Search author on:PubMed Google Scholar

  6. M. D’Urso
    View author publications

    Search author on:PubMed Google Scholar

  7. S. D. M. Brown
    View author publications

    Search author on:PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

D’Esposito, M., Quaderi, N.A., Ciccodicola, A. et al. Isolation, physical mapping, and Northern analysis of the X-linked human gene encoding methyl CpG-binding protein, MECP2. Mammalian Genome 7, 533–535 (1996). https://doi.org/10.1007/s003359900157

Download citation

  • Received: 02 January 1996

  • Accepted: 29 March 1996

  • Issue date: July 1996

  • DOI: https://doi.org/10.1007/s003359900157

Share this article

Anyone you share the following link with will be able to read this content:

Sorry, a shareable link is not currently available for this article.

Provided by the Springer Nature SharedIt content-sharing initiative

Keywords

  • Hybrid Cell Line
  • MECP2 Gene
  • Protein MeCP2
  • Multiple Tissue Northern Blot
  • Skeletal Muscle cDNA

Advertisement

Search

Navigation

  • Find a journal
  • Publish with us
  • Track your research

Footer Navigation

Discover content

  • Journals A-Z
  • Books A-Z

Publish with us

  • Journal finder
  • Publish your research
  • Language editing
  • Open access publishing

Products and services

  • Our products
  • Librarians
  • Societies
  • Partners and advertisers

Our brands

  • Springer
  • Nature Portfolio
  • BMC
  • Palgrave Macmillan
  • Apress
  • Discover

Corporate Navigation

  • Your US state privacy rights
  • Accessibility statement
  • Terms and conditions
  • Privacy policy
  • Help and support
  • Legal notice
  • Cancel contracts here

172.71.28.187

ICE Institution of Civil Engineers (3000167333) - Institution of Civil Engineers Library (2000027800)

Springer Nature

© 2026 Springer Nature