@coblhri
The Chris O'Brien Lifehouse Research Institute
Making routine head and neck pathology Easy: From dissection to diagnosis - PubMed
Making routine head and neck pathology Easy: From dissection to diagnosis - PubMed
Resections from the mobile tongue, the oropharynx and neck dissections constitute a large proportion of routine head and neck pathology workload. Histologically detected proximity to margins and prognostic factors like depth of invasion, perineural or lymphovascular invasion, or extranodal extension …
Stakeholder views on integrating prehabilitation in neoadjuvant therapy for breast cancer - ScienceDirect
Stakeholder views on integrating prehabilitation in neoadjuvant therapy for breast cancer - ScienceDirect
Neoadjuvant systemic therapy (NAST) for breast cancer can cause fatigue, neuropathy, and sleep disturbance, affecting treatment adherence and recovery…
The Effect of Prior Radiotherapy on Postoperative Complications in Patients Undergoing Free Flap Reconstruction of the Head and Neck - PubMed
The Effect of Prior Radiotherapy on Postoperative Complications in Patients Undergoing Free Flap Reconstruction of the Head and Neck - PubMed
Prior HNRT increases the risk of both flap and recipient-site complications. However, this mainly occurs in patients undergoing reconstruction of mucosal disease.
Impact of PD-L1 on first-line osimertinib outcomes in EGFR-mutant NSCLC: real-world data from the AURORA25 study and meta-analysis - PubMed
Impact of PD-L1 on first-line osimertinib outcomes in EGFR-mutant NSCLC: real-world data from the AURORA25 study and meta-analysis - PubMed
Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in TFCP2 Fusion-Defined Rhabdomyosarcoma - PubMed
Integration of Whole-Genome Sequencing Analysis with Unique Patient-Derived Models Reveals Clinically Relevant Drug Targets in TFCP2 Fusion-Defined Rhabdomyosarcoma - PubMed
Current Clinical Trials | Chris O'Brien Lifehouse
Current Clinical Trials | Chris O'Brien Lifehouse
A list of the current clinical trials at the Chris O'Brien Lifehouse. Patients can participate in a trial by contacting their GP.
Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma | Nature Communications
Histone methyltransferase PRDM9 promotes survival of drug-tolerant persister cells in glioblastoma | Nature Communications
Understanding the mechanisms underlying the survival of drug tolerant persister cells following chemotherapy remains elusive. Here, multi-omics analysis and experimental approaches show that the germ-cell-specific H3K4 methyltransferase PRDM9 promotes metabolic rewiring in glioblastoma stem cells.
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