@dementiabbg
We are the Brain Behaviour Group based at the Dementia Research Centre, UCL.
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The Brain Behaviour Group at UCL Dementia Research Centre
The Brain Behaviour Group at UCL Dementia Research Centre
Our research group investigates how brain pathology (the spread of abnormal proteins through neural circuits) produces symptoms of abnormal brain function (changes in behaviour) in major dementias.
Recent Papers
Hearing impairment and dementia: cause, catalyst or consequence? - Journal of Neurology
Hearing impairment and dementia: cause, catalyst or consequence? - Journal of Neurology
The relationship between hearing impairment and dementia has attracted significant attention, the 2024 Lancet Commission report identifying hearing loss as the largest modifiable risk factor for dementia from mid-life. The nature of this linkage between dementia and hearing remains unclear and is likely to be complex. In principle, hearing impairment could cause (directly promote), catalyze (amplify) or be a consequence of neurodegenerative pathology and cognitive decline. Here we use this framework to examine different lines of evidence for the association between hearing impairment and dementia, and consider how this evidence speaks to potential mechanisms and treatment implications. We conclude by considering practical clinical implications for management of patients with hearing impairment and dementia, the potential role for central hearing tests as ‘auditory biomarkers’ of dementia, and the need for further collaborative and mechanistically motivated research in this area.
Evaluating the link between hearing loss and Alzheimer’s disease neuropathology: A systematic review and meta-analysis
Evaluating the link between hearing loss and Alzheimer’s disease neuropathology: A systematic review and meta-analysis
Hearing loss has been linked with cognitive decline and increased dementia risk. The neurobiological mechanisms underlying this relationship are not c…
An international core outcome set for primary progressive aphasia (COS‐PPA): Consensus‐based recommendations for communication interventions across research and clinical settings
An international core outcome set for primary progressive aphasia (COS‐PPA): Consensus‐based recommendations for communication interventions across research and clinical settings
Comprehension of acoustically degraded emotional prosody in Alzheimer’s disease and primary progressive aphasia - Scientific Reports
Comprehension of acoustically degraded emotional prosody in Alzheimer’s disease and primary progressive aphasia - Scientific Reports
Primary progressive aphasia in Italian and English: A cross-linguistic cohort study.
Primary progressive aphasia in Italian and English: A cross-linguistic cohort study.
Background and ObjectivesCurrent formulations of primary progressive aphasia (PPA) derive largely from English-speaking patients. We hypothesized that language-specific characteristics influence PPA phenotypes in 2 contrasting languages: Italian and ...
Preserved musical working memory and absolute pitch in posterior cortical atrophy
Preserved musical working memory and absolute pitch in posterior cortical atrophy
Working memory for nonverbal auditory information is essential for everyday functioning but its cognitive organisation is not well understood. Here we…
Neurological eponyms? Take your Pick
Neurological eponyms? Take your Pick
The neuropsychiatrist Arnold Pick (1851–1924) lent his name to a disease, but in his centenary year, it is timely to ask whether this and the many other eponyms that populate neurology are more help than hindrance. Here, I survey some neurological eponyms, propose criteria for judging their helpfulness (and unhelpfulness) and consider their future prospects in our increasingly mechanistic, contemporary neurological practice. All data relevant to the study are included in the article or uploaded as online supplemental information.
An international core outcome set for primary progressive aphasia (COS-PPA): Consensus-based recommendations for communication interventions across research and clinical settings
An international core outcome set for primary progressive aphasia (COS-PPA): Consensus-based recommendations for communication interventions across research and clinical settings
INTRODUCTION Interventions to treat speech-language difficulties in primary progressive aphasia (PPA) often use word accuracy as a highly comparable outcome. However, there are more constructs of im...
Pure-tone audiometry and dichotic listening in primary progressive aphasia and Alzheimer’s disease
Pure-tone audiometry and dichotic listening in primary progressive aphasia and Alzheimer’s disease
Data-driven neuroanatomical subtypes of primary progressive aphasia
Data-driven neuroanatomical subtypes of primary progressive aphasia
Taylor et al. used a machine learning algorithm to identify data-driven profiles of brain atrophy in primary progressive aphasia, from a large dataset of p
Inappropriate trusting behaviour in dementia
Inappropriate trusting behaviour in dementia
Background: Inappropriate trusting behaviour may have significant social, financial and other consequences for people living with dementia. However, its clin...
Symptom‐based staging for logopenic variant primary progressive aphasia
Symptom‐based staging for logopenic variant primary progressive aphasia
Background and purpose Logopenic variant primary progressive aphasia (lvPPA) is a major variant presentation of Alzheimer's disease (AD) that signals the importance of communication dysfunction acro...
COS-PPA: protocol to develop a core outcome set for primary progressive aphasia
COS-PPA: protocol to develop a core outcome set for primary progressive aphasia
Dysphagia in primary progressive aphasia: Clinical predictors and neuroanatomical basis
Dysphagia in primary progressive aphasia: Clinical predictors and neuroanatomical basis
Background and purpose Dysphagia is an important feature of neurodegenerative diseases and potentially life-threatening in primary progressive aphasia (PPA) but remains poorly characterized in these...
Musical experience influences socio-emotional functioning in behavioural variant frontotemporal dementia
Musical experience influences socio-emotional functioning in behavioural variant frontotemporal dementia
Objectives: On phenotypic and neuroanatomical grounds, music exposure might potentially affect the clinical expression of behavioural variant frontotemporal ...
Binary reversals: a diagnostic sign in primary progressive aphasia
Binary reversals: a diagnostic sign in primary progressive aphasia
Pupil responses to colorfulness are selectively reduced in healthy older adults
Pupil responses to colorfulness are selectively reduced in healthy older adults
Primary progressive aphasia: six questions in search of an answer - Journal of Neurology
Primary progressive aphasia: six questions in search of an answer - Journal of Neurology
Here, we review recent progress in the diagnosis and management of primary progressive aphasia—the language-led dementias. We pose six key unanswered questions that challenge current assumptions and highlight the unresolved difficulties that surround these diseases. How many syndromes of primary progressive aphasia are there—and is syndromic diagnosis even useful? Are these truly ‘language-led’ dementias? How can we diagnose (and track) primary progressive aphasia better? Can brain pathology be predicted in these diseases? What is their core pathophysiology? In addition, how can primary progressive aphasia best be treated? We propose that pathophysiological mechanisms linking proteinopathies to phenotypes may help resolve the clinical complexity of primary progressive aphasia, and may suggest novel diagnostic tools and markers and guide the deployment of effective therapies.
Symptom-led staging for semantic and non-fluent/agrammatic variants of primary progressive aphasia
Symptom-led staging for semantic and non-fluent/agrammatic variants of primary progressive aphasia
INTRODUCTION Here we set out to create a symptom-led staging system for the canonical semantic and non-fluent/agrammatic variants of primary progressive aphasia (PPA), which present unique diagnosti...
Comprehension of acoustically degraded speech in Alzheimer’s disease and primary progressive aphasia
Comprehension of acoustically degraded speech in Alzheimer’s disease and primary progressive aphasia
Results from a randomised controlled pilot study of the Better Conversations with Primary Progressive Aphasia (BCPPA) communication partner training program for people with PPA and their communication partners - Pilot and Feasibility Studies
Results from a randomised controlled pilot study of the Better Conversations with Primary Progressive Aphasia (BCPPA) communication partner training program for people with PPA and their communication partners - Pilot and Feasibility Studies
‘Like going into a chocolate shop, blindfolded’: What do people with primary progressive aphasia want from speech and language therapy?
‘Like going into a chocolate shop, blindfolded’: What do people with primary progressive aphasia want from speech and language therapy?
The architecture of abnormal reward behaviour in dementia: multimodal hedonic phenotypes and brain substrate
The architecture of abnormal reward behaviour in dementia: multimodal hedonic phenotypes and brain substrate
Shouting from far away: three poems about living with speechlessness
Shouting from far away: three poems about living with speechlessness
The problematic syndrome of right temporal lobe atrophy: Unweaving the phenotypic rainbow
The problematic syndrome of right temporal lobe atrophy: Unweaving the phenotypic rainbow
Thinking eyes: visual thinking strategies and the social brain
Thinking eyes: visual thinking strategies and the social brain
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