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Review
. 2002 Sep 25;528(1-3):17-22.
doi: 10.1016/s0014-5793(02)03241-6.

The eye photoreceptor protein rhodopsin. Structural implications for retinal disease

Pere Garriga  1 , Joan Manyosa
Affiliations
Review

The eye photoreceptor protein rhodopsin. Structural implications for retinal disease

Pere Garriga et al. FEBS Lett. .

Abstract

Rhodopsin is the membrane receptor responsible for photoreception in the vertebrate retina. Its characteristic seven-transmembrane helical structural motif is today widely recognised as a paradigm in signal transduction. Rhodopsin and the phototransduction system are frequently used as structural and mechanistic models for the G-protein coupled receptor superfamily. Recent advances in the activation mechanism (as derived from the structural available data) and the implications for normal and pathological - in retinal disorders - visual function will be reviewed.

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