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. 2004 Sep 6;14(17):4585-9.
doi: 10.1016/j.bmcl.2004.04.107.

Non-peptide oxytocin agonists

Gary R W Pitt  1 , Andrzej R Batt, Robert M Haigh, Andrew M Penson, Peter A Robson, David P Rooker, André L Tartar, Julie E Trim, Christopher M Yea, Michael B Roe
Affiliations

Non-peptide oxytocin agonists

Gary R W Pitt et al. Bioorg Med Chem Lett. .

Abstract

A library of compounds targeted to the vasopressin/oxytocin family of receptors was screened for activity at a cloned human oxytocin receptor using a reporter gene assay. Potency and selectivity were optimised to afford compound 39, EC50 = 33 nM. This series of compounds represents the first disclosed, non-peptide, low molecular weight agonists of the hormone oxytocin (OT).

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