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. 2007 May;29(5):544-8.
doi: 10.1016/j.ijantimicag.2006.10.018. Epub 2007 Mar 29.

Continuous-infusion penicillin home-based therapy for serious infections due to penicillin-susceptible pathogens

Aaron L Walton  1 , Benjamin P Howden, Lindsay M Grayson, Tony M Korman
Affiliations

Continuous-infusion penicillin home-based therapy for serious infections due to penicillin-susceptible pathogens

Aaron L Walton et al. Int J Antimicrob Agents. 2007 May.

Abstract

To evaluate the feasibility of continuous-infusion (CI) penicillin in the treatment of serious bacterial infections, consecutive adult patients with deep-seated infections due to penicillin-susceptible pathogens were treated with CI aqueous penicillin G in a home-based programme, and their treatment outcomes were reviewed. Thirty-one patients with microbiologically proven infections completed the planned course of treatment. Twenty of 31 (65%) were followed for at least 2 months thereafter, and all remained free of relapse. One patient had fever attributable to penicillin hypersensitivity, two patients developed catheter-site infections and one patient developed catheter-related bacteraemia. Thus, CI penicillin is feasible for the home-based treatment of a variety of deep-seated infections with minimal toxicity.

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