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Review
. 2009 Feb;19(1):45-58.
doi: 10.1016/j.nic.2008.08.002.

Proton magnetic resonance spectroscopy in multiple sclerosis

Balasrinivasa R Sajja  1 , Jerry S Wolinsky, Ponnada A Narayana
Affiliations
Review

Proton magnetic resonance spectroscopy in multiple sclerosis

Balasrinivasa R Sajja et al. Neuroimaging Clin N Am. 2009 Feb.

Abstract

Proton magnetic resonance spectroscopy ((1)H-MRS) provides tissue metabolic information in vivo. This article reviews the role of MRS-determined metabolic alterations in lesions, normal-appearing white matter, gray matter, and spinal cord in advancing our knowledge of pathologic changes in multiple sclerosis (MS). In addition, the role of MRS in objectively evaluating therapeutic efficacy is reviewed. This potential metabolic information makes MRS a unique tool to follow MS disease evolution, understand its pathogenesis, evaluate the disease severity, establish a prognosis, and objectively evaluate the efficacy of therapeutic interventions.

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Figures

Figure 1
Figure 1
Application of outer volume suppression bands to minimize extrameningeal tissue contamination. Left: Eight outer volume suppression bands on one of the five images (each, 3 mm thickness) that represent the spectroscopic volume of interest (15 mm thickness); right: localized image(15 mm slice thickness with the application of the suppression bands) from which 1H-MRSI is acquired.
Figure 2
Figure 2
Single voxel spectra with short TE (=35 msec) and long TE (=144 msec) acquired from white matter region of a normal brain at 3.0 Tesla. The large number of metabolite peaks with broad baseline can be observed in the short TE spectrum (top). In contrast, long TE spectrum (bottom) has relatively flat baseline and fewer metabolite peaks. See text for abbreviations
Figure 3
Figure 3
Abnormal peaks in normal-appearing white matter of a patient with primary progressive multiple sclerosis. Top: Left: One of the five MR images (each 3 mm thick) of the cross-section of the brain location from where the 1H-MRSI data acquired. Right: Collapsed image representing the spectroscopic volume of interest (thickness=15 mm). The small grid on the collapsed image represents the spatial location shown in the bottom panel. Strong lipid peaks can be observed in these spectra. The spectra were acquired at TE of 30 ms.
See this image and copyright information in PMC

References

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