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. 2013 Jan;141(1):195-9.
doi: 10.1017/S0950268812000453. Epub 2012 Apr 4.

Multilocus sequence typing (MLST) analysis of 104 Clostridium difficile strains isolated from China

Q Yan  1 , J Zhang, C Chen, H Zhou, P Du, Z Cui, R Cen, L Liu, W Li, B Cao, J Lu, Y Cheng
Affiliations

Multilocus sequence typing (MLST) analysis of 104 Clostridium difficile strains isolated from China

Q Yan et al. Epidemiol Infect. 2013 Jan.

Abstract

The phylogenetic and epidemic relationships of 104 clinical isolates of Clostridium difficile from three hospitals of different geographical and population sources in China were investigated by multilocus sequence typing. Twenty-two sequence types (STs) were identified, four of which, ST117, ST118, ST119 and ST129, were novel. No geographically specific and host population-specific phylogenetic lineages were found and there was no correlation between geographical origin or host population and strain genotype. ST37 was the dominant type in our survey but the four novel STs underline the high genetic diversity and unique polymorphisms in C. difficile from China.

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Figures

Fig. 1.
Fig. 1.
Neighbour-joining tree constructed based on the composite sequence of seven housekeeping gene fragments. Bootstraps were generated using 1000 replicates. BJ, Beijing; SD, Shandong; GZ, Guangzhou; ◂, new sequence types.
See this image and copyright information in PMC

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