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. 2021 Jan;11(1):92-107.
doi: 10.1158/2159-8290.CD-20-0553. Epub 2020 Sep 21.

Triplet Therapy with Palbociclib, Taselisib, and Fulvestrant in PIK3CA-Mutant Breast Cancer and Doublet Palbociclib and Taselisib in Pathway-Mutant Solid Cancers

Javier Pascual  1   2 , Joline S J Lim  3 , Iain R Macpherson  4 , Anne C Armstrong  5 , Alistair Ring  1 , Alicia F C Okines  1 , Rosalind J Cutts  2 , Maria Teresa Herrera-Abreu  2 , Isaac Garcia-Murillas  2 , Alex Pearson  2 , Sarah Hrebien  2 , Heidrun Gevensleben  6 , Paula Z Proszek  7 , Michael Hubank  7 , Margaret Hills  8 , Jenny King  9 , Mona Parmar  9 , Toby Prout  9 , Laura Finneran  9 , Jason Malia  10 , Karen E Swales  10 , Ruth Ruddle  10 , Florence I Raynaud  10 , Alison Turner  9 , Emma Hall  9 , Timothy A Yap  11 , Juanita S Lopez  9 , Nicholas C Turner  12   2   8
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Free article

Triplet Therapy with Palbociclib, Taselisib, and Fulvestrant in PIK3CA-Mutant Breast Cancer and Doublet Palbociclib and Taselisib in Pathway-Mutant Solid Cancers

Javier Pascual et al. Cancer Discov. 2021 Jan.
Free article

Abstract

Cyclin-dependent kinase 4/6 (CDK4/6) and PI3K inhibitors synergize in PIK3CA-mutant ER-positive HER2-negative breast cancer models. We conducted a phase Ib trial investigating the safety and efficacy of doublet CDK4/6 inhibitor palbociclib plus selective PI3K inhibitor taselisib in advanced solid tumors, and triplet palbociclib plus taselisib plus fulvestrant in 25 patients with PIK3CA-mutant, ER-positive HER2-negative advanced breast cancer. The triplet therapy response rate in PIK3CA-mutant, ER-positive HER2-negative cancer was 37.5% [95% confidence interval (CI), 18.8-59.4]. Durable disease control was observed in PIK3CA-mutant ER-negative breast cancer and other solid tumors with doublet therapy. Both combinations were well tolerated at pharmacodynamically active doses. In the triplet group, high baseline cyclin E1 expression associated with shorter progression-free survival (PFS; HR = 4.2; 95% CI, 1.3-13.1; P = 0.02). Early circulating tumor DNA (ctDNA) dynamics demonstrated high on-treatment ctDNA association with shorter PFS (HR = 5.2; 95% CI, 1.4-19.4; P = 0.04). Longitudinal plasma ctDNA sequencing provided genomic evolution evidence during triplet therapy. SIGNIFICANCE: The triplet of palbociclib, taselisib, and fulvestrant has promising efficacy in patients with heavily pretreated PIK3CA-mutant ER-positive HER2-negative advanced breast cancer. A subset of patients with PIK3CA-mutant triple-negative breast cancer derived clinical benefit from palbociclib and taselisib doublet, suggesting a potential nonchemotherapy targeted approach for this population.This article is highlighted in the In This Issue feature, p. 1.

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