Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2021 May 6;26(9):2732.
doi: 10.3390/molecules26092732.

Mango (Mangifera indica L.) Polyphenols: Anti-Inflammatory Intestinal Microbial Health Benefits, and Associated Mechanisms of Actions

Hyemee Kim  1 , Maria Joselyn Castellon-Chicas  2 , Shirley Arbizu  2 , Stephen T Talcott  2 , Nicholas L Drury  2 , Shayna Smith  2 , Susanne U Mertens-Talcott  2
Affiliations
Review

Mango (Mangifera indica L.) Polyphenols: Anti-Inflammatory Intestinal Microbial Health Benefits, and Associated Mechanisms of Actions

Hyemee Kim et al. Molecules. .

Abstract

Mango is rich in polyphenols including gallotannins and gallic acid, among others. The bioavailability of mango polyphenols, especially polymeric gallotannins, is largely dependent on the intestinal microbiota, where the generation of absorbable metabolites depends on microbial enzymes. Mango polyphenols can favorably modulate bacteria associated with the production of bioactive gallotannin metabolites including Lactobacillus plantarum, resulting in intestinal health benefits. In several studies, the prebiotic effects of mango polyphenols and dietary fiber, their potential contribution to lower intestinal inflammation and promotion of intestinal integrity have been demonstrated. Additionally, polyphenols occurring in mango have some potential to interact with intestinal and less likely with hepatic enzymes or transporter systems. This review provides an overview of interactions of mango polyphenols with the intestinal microbiome, associated health benefits and underlying mechanisms.

Keywords: gut health; gut microbiota; inflammation; intestinal integrity; mango polyphenols; polyphenol metabolites.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Overview of the proposed mechanism of actions of mango polyphenols and fiber consumption on human intestinal health. Mango polyphenols and fiber may promote gut health through their pharmacological activities, modulation of beneficial gut microbiota (tannase, gallate decarboxylase, and butyrate-producing bacteria) and thus, contribute to maintaining the gut barrier and cognitive function. Created using BioRender (https://biorender.com/, accessed on 15 April 2021) as part of Academic License.
See this image and copyright information in PMC

References

    1. Yadav D., Singh S. Mango: History origin and distribution. J. Pharmacogn. Phytochem. 2017;6:1257–1262.
    1. Evans E.A., Ballen F.H., Siddiq M. Mango Production, Global Trade, Consumption Trends and Postharvest Processing and Nutrition. John Wiley & Sons; Chichester, UK: 2017. pp. 1–16.
    1. Tharanathan R., Yashoda H., Prabha T. Mango (Mangifera indica L.),“The king of fruits”—An overview. Food Rev. Int. 2006;22:95–123. doi: 10.1080/87559120600574493. - DOI
    1. Litz R.E. Mango in Compendium of Transgenic Crop Plants. Wiley-Backwell; New York, NY, USA: 2009. pp. 163–174.
    1. Gentile C., Di Gregorio E., Di Stefano V., Mannino G., Perrone A., Avellone G., Sortino G., Inglese P., Farina V. Food quality and nutraceutical value of nine cultivars of mango (Mangifera indica L.) fruits grown in Mediterranean subtropical environment. Food Chem. 2019;277:471–479. doi: 10.1016/j.foodchem.2018.10.109. - DOI - PubMed

LinkOut - more resources