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. 2024 Sep 13;30(18):3968-3970.
doi: 10.1158/1078-0432.CCR-24-1188.

PIKing up and AKTing on Resistance Mutations in Osimertinib-Treated EGFR-Mutated NSCLC

Natalie I Vokes  1   2 , Xiuning Le  1 , Timothy A Yap  1   3   4   5
Affiliations

PIKing up and AKTing on Resistance Mutations in Osimertinib-Treated EGFR-Mutated NSCLC

Natalie I Vokes et al. Clin Cancer Res. .

Abstract

A recent study identified high rates of PI3K-AKT pathway mutations from the FLAURA and AURA3 osimertinib trials and pre-clinically validated that these mutations decreased osimertinib sensitivity in EGFR-mutated non-small cell lung cancer. The AKT inhibitor capivasertib was found to overcome this resistance, providing an important rationale for the development of AKT inhibitors in non-small cell lung cancer. See related article by Grazini et al., p. 4143.

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