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. 2026 Feb 19;147(8):897-901.
doi: 10.1182/blood.2024028042.

Utility of peripheral blood testing for detection and surveillance of clonal hematopoiesis in predisposed individuals

Enrico Attardi  1   2 , Nathan Gray  1 , Sara Lewis  1 , Michelle Boals  1 , Passant Shaker  1 , Lili Kotmayer  1 , Sushree S Sahoo  1 , Peng Li  3 , Erica F Andersen  3 , Jian Zhao  3 , Lucilla Pizzo  3 , Joseph H Oved  4 , Rohith Jesudas  1 , Ulrike M Reiss  1 , Richa Sharma  1 , Georgios E Christakopoulos  1 , Senthil Velan Bhoopalan  5 , Clifford M Takemoto  1 , Alyssa Kennedy  1 , Maria Teresa Voso  2 , Guolian Kang  6 , Marcin W Wlodarski  1
Affiliations

Utility of peripheral blood testing for detection and surveillance of clonal hematopoiesis in predisposed individuals

Enrico Attardi et al. Blood. .

Abstract

In this study, 108 pediatric patients with bone marrow (BM) failure and leukemia predisposition were evaluated for presence of clonal hematopoiesis in peripheral blood (PB) and BM. Robust PB-BM concordance for mutations but decreased sensitivity in PB for chromosomal abnormalities was found.

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Conflict of interest statement

Conflict-of-interest disclosure: M.W.W reports receiving honoraria from the National Cancer Institute (NCI), National Institutes of Health (NIH) for participation as an author in the NCI/NIH Physician Data Query and for providing consulting for Retro Bio, Guidepoint, and OLG Research and Consulting, all unrelated to this work. R.J. reports providing consulting for Merck and Genzyme, unrelated to this work. C.M.T. reports serving in the data monitoring committee for Novartis’ eltrombopag aplastic anemia trial; serving as a principal investigator for sickle cell disease drug for Pfizer site; and serving as a Merck consultant for anticoagulation, all unrelated to this work. The remaining authors declare no competing interests.

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