Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1997 Sep;61(3):505-11.
doi: 10.1086/515519.

HLA and mate selection: no evidence in South Amerindians

P W Hedrick  1 , F L Black
Affiliations

HLA and mate selection: no evidence in South Amerindians

P W Hedrick et al. Am J Hum Genet. 1997 Sep.

Abstract

There have been reports of nonrandom mating (negative-assortative mating) or preference for individuals of different major histocompatibility complex (MHC) genotypes in both mice and humans. We have examined the association of HLA-A and HLA-B genotypes, both for each locus by itself and for two-locus genotypes, in mates of 194 couples from 11 South Amerindian tribes. The proportion of couples sampled averaged >50% of the total matings with progeny for 10 of the tribes. In nearly all cases, HLA-sharing proportions were very close to those expected from random mating, suggesting strong negative-assortative mating for MHC is not present in these South Amerindians.

PubMed Disclaimer

Comment in

References

    1. Tissue Antigens. 1980 Nov;16(5):368-76 - PubMed
    1. Am J Hum Genet. 1981 Nov;33(6):894-9 - PubMed
    1. Immunogenetics. 1982;15(6):579-89 - PubMed
    1. Immunogenetics. 1983;17(1):89-93 - PubMed
    1. Genetics. 1983 Jul;104(3):449-56 - PubMed

Publication types