Predicting Radiation Pneumonitis After Chemoradiation Therapy for Lung Cancer: An International Individual Patient Data Meta-analysis

Palma, David A.; Senan, Suresh; Tsujino, Kayoko; Barriger, R. Bryan; Rengan, Ramesh; Moreno, Marta; Bradley, Jeffrey D.; Kim, Tae Hyun; Ramella, Sara; Marks, Lawrence B.; Petris, Luigi De; Stitt, Larry; Rodrigues, George

doi:10.1016/j.ijrobp.2012.04.043

International Journal of Radiation Oncology*Biology*Physics

2013

DOI: 10.1016/j.ijrobp.2012.04.043

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Predicting Radiation Pneumonitis After Chemoradiation Therapy for Lung Cancer: An International Individual Patient Data Meta-analysis

David A. Palma

¹

,

Suresh Senan

²

,

Kayoko Tsujino

³

et al.

Abstract: Background Radiation pneumonitis is a dose-limiting toxicity for patients undergoing concurrent chemoradiation therapy (CCRT) for non-small cell lung cancer (NSCLC). We performed an individual patient data meta-analysis to determine factors predictive of clinically significant pneumonitis. Methods After a systematic review of the literature, data was obtained on 836 patients who underwent CCRT in Europe, North America and Asia. Patients were randomly divided into training and validation sets (2/3 vs. 1/3 of … Show more

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Cited by 635 publications

(556 citation statements)

References 20 publications

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32

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501

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“…Our all-grade pneumonitis incidence was 26.6% (181, N=680) while the incidence of pneumonitis Grade ≥3 was 13% (89, N=680) as compared to 19% and 11% (36 and 21, N=188) in Voong’s study. Our RP incidence was much lower and not consistent with the reported 40% in the Palma et al study [ 10 ]. However, the 40% referred to the estimated average range of 13% to 37% based on findings of two other studies; the first had a protocol of high radiation dose (66 Gy) and the second used a calculation that "overestimated the actual observed rated for RP" [ 11 ].…”

Section: Discussioncontrasting

confidence: 99%

Comparison of Pneumonitis Rates and Severity in Patients With Lung Cancer Treated by Immunotherapy, Radiotherapy, and Immunoradiotherapy

Aiad

¹

,

Fresco

²

,

Prenatt

³

et al. 2022

Cureus

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Our all-grade pneumonitis incidence was 26.6% (181, N=680) while the incidence of pneumonitis Grade ≥3 was 13% (89, N=680) as compared to 19% and 11% (36 and 21, N=188) in Voong’s study. Our RP incidence was much lower and not consistent with the reported 40% in the Palma et al study [ 10 ]. However, the 40% referred to the estimated average range of 13% to 37% based on findings of two other studies; the first had a protocol of high radiation dose (66 Gy) and the second used a calculation that "overestimated the actual observed rated for RP" [ 11 ].…”

Section: Discussioncontrasting

confidence: 99%

Comparison of Pneumonitis Rates and Severity in Patients With Lung Cancer Treated by Immunotherapy, Radiotherapy, and Immunoradiotherapy

Aiad

¹

,

Fresco

²

,

Prenatt

³

et al. 2022

Cureus

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…In our study, the high-grade group received a higher mean radiation dose but lower V20 than the low-grade group. This finding is contrast with the meta-analysis published by Palma et al [ 32 ] The absence of a significant association in this study between RP grade and radiation parameters could be due to the limited sample size, the small differences among patients with regards to the radiation dose and biological predisposition [ 9 ].…”

Section: Discussioncontrasting

confidence: 99%

Severity of radiation pneumonitis, from clinical, dosimetric and biological features: a pilot study

Aso

¹

,

Navarro-Martín

²

,

Castillo

³

et al. 2020

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…3,8 In our study, the high-grade group received a higher mean radiation dose but lower V20 than the low-grade group. This nding is contrast with the meta-analysis published by Palma et al 32 The absence of a signi cant association in this study between RP grade and radiation parameters could be due to the limited sample size, the small differences among patients with regards to the radiation dose and biological predisposition. 9 RP increases cellular metabolism.…”

Section: Discussioncontrasting

confidence: 99%

Severity of radiation pneumonitis, from clinical, dosimetric and biological features: a pilot study.

Aso

¹

,

Navarro-Martín

²

,

Castillo

³

et al. 2020

Preprint

0

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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