Limitations in qualitative point of care hCG tests for detecting early pregnancy

Greene, Dina N.; Schmidt, Robert L.; Kamer, Sandy; Grenache, David G.; Lorey, Thomas

doi:10.1016/j.cca.2012.10.053

Clinica Chimica Acta

2013

DOI: 10.1016/j.cca.2012.10.053

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Limitations in qualitative point of care hCG tests for detecting early pregnancy

Dina N. Greene

¹

,

Robert L. Schmidt

²

,

Sandy Kamer

³

et al.

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Cited by 40 publications

(23 citation statements)

References 10 publications

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“…Such discrepancies in visual interpretation of faint positive POC urinary hCG device results have been previously described [11,19]. Inter-interpreter agreement was only 61% and 84% for simultaneous POC urinary hCG testing using QuickVue + and OSOM, respectively [19]. The striking result discrepancy rates based on visual interpretation of select POC urinary hCG devices highlights this failure mode.…”

Section: Discussionmentioning

confidence: 81%

Using a simulation model to assess risk of false negative point-of-care urinary human chorionic gonadotropin device results due to high-dose hook interference

Milhorn

¹

,

Korpi‐Steiner²

2015

Clinical Biochemistry

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Such discrepancies in visual interpretation of faint positive POC urinary hCG device results have been previously described [11,19]. Inter-interpreter agreement was only 61% and 84% for simultaneous POC urinary hCG testing using QuickVue + and OSOM, respectively [19]. The striking result discrepancy rates based on visual interpretation of select POC urinary hCG devices highlights this failure mode.…”

Section: Discussionmentioning

confidence: 81%

Using a simulation model to assess risk of false negative point-of-care urinary human chorionic gonadotropin device results due to high-dose hook interference

Milhorn

¹

,

Korpi‐Steiner²

2015

Clinical Biochemistry

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Here, the patient's urine hCG was negative using a qualitative point-of-care device. This result was not unexpected, though, given the inferior analytical sensitivities of these devices, making them susceptible to false-negative results at low urine hCG concentrations (4,5). Interestingly, detectorspecific false-positive hCG results have also been reported, but not for the specific assays used here (6,7).…”

Section: Discussionmentioning

confidence: 85%

Persistently Elevated Human Chorionic Gonadotropin in a Menopausal Woman

Merrill

¹

,

Holmes

²

,

Severin

³

et al. 2016

The Journal of Applied Laboratory Medicine

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…The most intuitive reason for this false-negative test is dilute urine 3. A false-negative urine test can also occur with ‘high dose hook effect’, which probably occurred in this case.…”

Section: Discussionmentioning

confidence: 86%

Negative urine pregnancy test in a molar pregnancy: is it possible?

Nigam

¹

,

Kumari

²

,

Gupta

³

2014

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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