International Union of Basic and Clinical Pharmacology. LXXXVIII. G Protein-Coupled Receptor List: Recommendations for New Pairings with Cognate Ligands

“…As shown in Figures 3c and S8C, CCL5 (0.1–10 nM) alone or in the presence of CRAs failed to increase β‐arrestin recruitment to GPR75, confirming previous reports (Davenport et al, 2013; Southern et al, 2013). However, co‐treatment of 20‐HETE and CCL5 in the presence and absence of CRAs prevented the 20‐HETE‐mediated increase in β‐arrestin recruitment (Figure 3c).…”

“…These responses were blocked by S1P and LPA receptor antagonists and by RNA silencing of P2Y10, leading to the hypothesis that P2Y10 is a dual S1P/LPA receptor. However, these findings were not confirmed by others 15,34,58 . In line with this, we found that S1P-and LPA-induced RhoA activation was not changed in P2Y10-deficient CD4 T cells.…”

“…However, the CMKLR expression levels of Atlantic salmon ( Salmo salar ) [27] and rainow trout ( Oncorhynchus mykiss ) [28] were detected at a relatively higher level in the head kidney and were observed at a lower level in gill, muscle, and liver, which is inconsistent with the results in cobia. The CMKLR1 is highly expressed in mammalian adipose tissues and has been proved to mediate chemerin's actions in insulin signaling and adipocyte metabolism [29] , [30] .…”

“…As shown in Figures 3c and S8C, CCL5 (0.1–10 nM) alone or in the presence of CRAs failed to increase β‐arrestin recruitment to GPR75, confirming previous reports (Davenport et al, 2013; Southern et al, 2013). However, co‐treatment of 20‐HETE and CCL5 in the presence and absence of CRAs prevented the 20‐HETE‐mediated increase in β‐arrestin recruitment (Figure 3c).…”

“…These responses were blocked by S1P and LPA receptor antagonists and by RNA silencing of P2Y10, leading to the hypothesis that P2Y10 is a dual S1P/LPA receptor. However, these findings were not confirmed by others 15,34,58 . In line with this, we found that S1P-and LPA-induced RhoA activation was not changed in P2Y10-deficient CD4 T cells.…”

“…However, the CMKLR expression levels of Atlantic salmon ( Salmo salar ) [27] and rainow trout ( Oncorhynchus mykiss ) [28] were detected at a relatively higher level in the head kidney and were observed at a lower level in gill, muscle, and liver, which is inconsistent with the results in cobia. The CMKLR1 is highly expressed in mammalian adipose tissues and has been proved to mediate chemerin's actions in insulin signaling and adipocyte metabolism [29] , [30] .…”

“…As shown in Figures 3c and S8C, CCL5 (0.1–10 nM) alone or in the presence of CRAs failed to increase β‐arrestin recruitment to GPR75, confirming previous reports (Davenport et al, 2013; Southern et al, 2013). However, co‐treatment of 20‐HETE and CCL5 in the presence and absence of CRAs prevented the 20‐HETE‐mediated increase in β‐arrestin recruitment (Figure 3c).…”

“…These responses were blocked by S1P and LPA receptor antagonists and by RNA silencing of P2Y10, leading to the hypothesis that P2Y10 is a dual S1P/LPA receptor. However, these findings were not confirmed by others 15,34,58 . In line with this, we found that S1P-and LPA-induced RhoA activation was not changed in P2Y10-deficient CD4 T cells.…”

“…However, the CMKLR expression levels of Atlantic salmon ( Salmo salar ) [27] and rainow trout ( Oncorhynchus mykiss ) [28] were detected at a relatively higher level in the head kidney and were observed at a lower level in gill, muscle, and liver, which is inconsistent with the results in cobia. The CMKLR1 is highly expressed in mammalian adipose tissues and has been proved to mediate chemerin's actions in insulin signaling and adipocyte metabolism [29] , [30] .…”