Faecalibacterium prausnitzii and human intestinal health

Miquel, Sylvie; Martín, Rebeca; Rossi, Oriana; Bermúdez‐Humarán, Luis G.; Chatel, JM; Sokol, Harry; Thomas, Muriel; Wells, JM; Langella, Philippe

doi:10.1016/j.mib.2013.06.003

Current Opinion in Microbiology

2013

DOI: 10.1016/j.mib.2013.06.003

|Get access via publisher |Summarize |Cite

|

Sign up to set email alerts

Faecalibacterium prausnitzii and human intestinal health

Sylvie Miquel

¹

,

Rebeca Martín

²

,

Oriana Rossi

³

et al.

Help me understand this report

Cited by 1,177 publications

(895 citation statements)

References 63 publications

Supporting

37

Mentioning

838

Contrasting

3

Unclassified

17

Order By: Relevance

“…To specify the key bioactive components in FP-CS responsible for inhibiting NKTCL growth, we applied the HM700 metabolome (a high-throughput targeted quantification kit for metabolites based on liquid chromatograph-mass spectrometry21) to preliminarily screen the metabolites in FP-CS and revealed an eminently elevated level of butyric acid in FP-CS compared with the blank culture medium of F. prausnitzii (figure 3J). Subsequently, targeted metabolomic analysis of short-chain fatty acids (SCFAs) further verified a substantial increase in butyric acid level in FP-CS (figure 3K,M), which aligns with previous findings that the commensal bacterium F. prausnitzii constitutes more than 5% of the total bacterial population in healthy adults and represents one of the predominant butyrate-producing bacteria in the gastrointestinal tract 22…”

Section: Resultssupporting

confidence: 89%

Butyrate-producing Faecalibacterium prausnitzii suppresses natural killer/T-cell lymphoma by dampening the JAK-STAT pathway

Shi

¹

,

Li

²

,

Zhang

³

et al. 2024

Gut

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…To specify the key bioactive components in FP-CS responsible for inhibiting NKTCL growth, we applied the HM700 metabolome (a high-throughput targeted quantification kit for metabolites based on liquid chromatograph-mass spectrometry21) to preliminarily screen the metabolites in FP-CS and revealed an eminently elevated level of butyric acid in FP-CS compared with the blank culture medium of F. prausnitzii (figure 3J). Subsequently, targeted metabolomic analysis of short-chain fatty acids (SCFAs) further verified a substantial increase in butyric acid level in FP-CS (figure 3K,M), which aligns with previous findings that the commensal bacterium F. prausnitzii constitutes more than 5% of the total bacterial population in healthy adults and represents one of the predominant butyrate-producing bacteria in the gastrointestinal tract 22…”

Section: Resultssupporting

confidence: 89%

Butyrate-producing Faecalibacterium prausnitzii suppresses natural killer/T-cell lymphoma by dampening the JAK-STAT pathway

Shi

¹

,

Li

²

,

Zhang

³

et al. 2024

Gut

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…With regard to the sources of these 84 F . prausnitzii strains, we found that a majority of strains were isolated from the feces of humans, such as F. prausnitzii KLE1255, F. prausnitzii APC918/95b, and F. prausnitzii A2165, which was consistent with the finding that F. prausnitzii is dominant in the intestinal tract of humans ( Miquel et al., 2013 ). Although the genomes of 84 F .…”

Section: Resultssupporting

confidence: 89%

Comprehensive analysis of 84 Faecalibacterium prausnitzii strains uncovers their genetic diversity, functional characteristics, and potential risks

Bai

¹

,

Zhang

²

,

Jin

³

et al. 2023

Front. Cell. Infect. Microbiol.

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Our findings further show that F. prausnitzii accounts for approximately 18% of the total faecal gut microbiota in senior orienteers compared to 15% among community-dwelling older adults. This is in accordance with two previous independent studies showing that 5-15% of the microbiota consists of F. prausnitzii [39,54]. This observation may indicate that senior orienteers have a higher production of butyrate.…”

Section: Discussionsupporting

confidence: 93%

Differences in Gut Microbiome Composition between Senior Orienteering Athletes and Community-Dwelling Older Adults

Fart

¹

,

Rajan

²

,

Wall

³

et al. 2020

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

Scite is an AI-powered platform that helps researchers discover and evaluate scientific literature through Smart Citations, showing whether studies support or contradict a claim. Now part of Research Solutions, Scite has indexed 1.6B+ citations, partners with 30+ publishers, and serves 2M users worldwide.

Contact Info

customersupport@researchsolutions.com

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA