Intl Journal of Cancer
 2014
DOI: 10.1002/ijc.28751
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Cancer prevention by adult‐onset calorie restriction after infant exposure to ionizing radiation in B6C3F1 male mice

Yi Shang1,
Shizuko Kakinuma2,
K. Yamauchi
3
et al.

Abstract: Children are especially sensitive to ionizing radiation and chemical carcinogens, and limiting their cancer risk is of great public concern. Calorie restriction (CR) is a potent intervention for suppressing cancer. However, CR is generally not appropriate for children. This study, therefore, examined to see if adult-onset CR influences the lifetime cancer risk in mice after early-life exposure to ionizing radiation. Infant male mice (1-week-old) were exposed to 3.8 Gy X-rays, fed a control 95 kcal/week or CR 6… Show more

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Cited by 36 publications

(52 citation statements)
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“…S1 ). Consistent with our previous reports using infant mice [ 11 , 12 ], these data suggest that radiation exposure at infancy rapidly and predominantly induces T-cell neoplasms.…”
Section: Resultssupporting
confidence: 92%
“…Interestingly, consistent with this result, the risk of developing pre-B lymphoid neoplasm is slightly increased in patients who were exposed to diagnostic X-rays at <15 years of age [ 24 ]. In accord with our previous reports [ 11 , 12 ], we also observed that T-cell neoplasm was induced soon after radiation exposure during infancy with high frequency, and the incidence was higher in male than in female mice. Consistent with this, a potential increase in the incidence of T-cell neoplasm has also been reported for patients who have undergone radiation therapy for cancer at <18 years of age [ 10 ].…”
Section: Discussionsupporting
confidence: 93%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…S1 ). Consistent with our previous reports using infant mice [ 11 , 12 ], these data suggest that radiation exposure at infancy rapidly and predominantly induces T-cell neoplasms.…”
Section: Resultssupporting
confidence: 92%
“…Interestingly, consistent with this result, the risk of developing pre-B lymphoid neoplasm is slightly increased in patients who were exposed to diagnostic X-rays at <15 years of age [ 24 ]. In accord with our previous reports [ 11 , 12 ], we also observed that T-cell neoplasm was induced soon after radiation exposure during infancy with high frequency, and the incidence was higher in male than in female mice. Consistent with this, a potential increase in the incidence of T-cell neoplasm has also been reported for patients who have undergone radiation therapy for cancer at <18 years of age [ 10 ].…”
Section: Discussionsupporting
confidence: 93%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Fourth, more than 90% of mice herein were terminated at a humane endpoint, whereas historical studies often used natural death as the study endpoint. Of note, two historical studies terminating the B6C3F1 mice at their natural death [ 21 , 22 ] and the recent two studies adopting humane endpoints in the same strain (Shang et al and the present study) [ 23 ] have shown similar average lifespans among the nontreated animal groups. This indicates that the set of humane endpoints adopted herein is a very good surrogate for animal death.…”
Section: Discussionsupporting
confidence: 53%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…3,44 Using mice, we previously demonstrated that CR in effectively prevented HCC that developed with age in nontreated animals as well as those exposed to radiation as infants, ultimately extending lifespan. 10 Indeed, in our study, both radiation exposure and CR resulted in body-weight loss, although exposure to 3.8 Gy of X-rays effectively promoted tumor induction whereas CR suppressed tumorigenesis. It is well established that intentional bodyweight loss contributes to reduced cancer risk.…”
Section: Discussionmentioning
confidence: 47%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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