Plasma homocysteine, dietary B vitamins, betaine, and choline and risk of peripheral artery disease

Bertoia, Monica L.; Pai, Jennifer K.; Cooke, John P.; Joosten, Michel M.; Mittleman, Murray A.; Rimm, Eric B.; Mukamal, Kenneth J.

doi:10.1016/j.atherosclerosis.2014.04.010

Atherosclerosis

2014

DOI: 10.1016/j.atherosclerosis.2014.04.010

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Plasma homocysteine, dietary B vitamins, betaine, and choline and risk of peripheral artery disease

Monica L. Bertoia

¹

,

Jennifer K. Pai

²

,

John P. Cooke

³

et al.

Abstract: Objective Few studies have examined the roles of homocysteine and related nutrients in the development of peripheral artery disease (PAD). We examined the associations between plasma homocysteine, dietary B vitamins, betaine, choline, and supplemental folic acid use and incidence of PAD. Methods We used two cohort studies of 72,348 women in the Nurses' Health Study (NHS, 1990-2010) and 44,504 men in the Health Professionals Follow-up Study (HPFS, 1986-2010). We measured plasma homocysteine in nested matched … Show more

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Cited by 70 publications

(41 citation statements)

References 59 publications

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3

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“…We also observed lower levels of most one-carbon metabolites in women compared to men. This finding is consistent with some prior studies for total homocysteine 32 , betaine, and choline 33 , 34 , though one study found the opposite pattern 35 .…”

Section: Discussionsupporting

confidence: 92%

“…The fat-soluble vitamins A, D, and E are important for a variety of physiological functions relevant to potential associations between deficiencies and cancer 7 . We found higher concentrations of most B-vitamins in women, although some studies showed the opposite pattern for PLP, folate 32 , cobalamin, and B6 34 . Previously reported sex differences in riboflavin levels 34 , 37 were not present in our data.…”

Section: Discussionmentioning

confidence: 45%

“…We found higher concentrations of most B-vitamins in women, although some studies showed the opposite pattern for PLP, folate 32 , cobalamin, and B6 34 . Previously reported sex differences in riboflavin levels 34 , 37 were not present in our data. One possible explanation is that women used more multivitamin supplements than men in our dataset (Supplementary Tables 6 and 7 ).…”

Section: Discussionmentioning

confidence: 45%

See 2 more Smart Citations

Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults

Zahed

¹

,

Johansson

²

,

Ueland

³

et al. 2021

Sci Rep

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…We also observed lower levels of most one-carbon metabolites in women compared to men. This finding is consistent with some prior studies for total homocysteine 32 , betaine, and choline 33 , 34 , though one study found the opposite pattern 35 .…”

Section: Discussionsupporting

confidence: 92%

“…The fat-soluble vitamins A, D, and E are important for a variety of physiological functions relevant to potential associations between deficiencies and cancer 7 . We found higher concentrations of most B-vitamins in women, although some studies showed the opposite pattern for PLP, folate 32 , cobalamin, and B6 34 . Previously reported sex differences in riboflavin levels 34 , 37 were not present in our data.…”

Section: Discussionmentioning

confidence: 45%

“…We found higher concentrations of most B-vitamins in women, although some studies showed the opposite pattern for PLP, folate 32 , cobalamin, and B6 34 . Previously reported sex differences in riboflavin levels 34 , 37 were not present in our data. One possible explanation is that women used more multivitamin supplements than men in our dataset (Supplementary Tables 6 and 7 ).…”

Section: Discussionmentioning

confidence: 45%

See 1 more Smart Citation

Epidemiology of 40 blood biomarkers of one-carbon metabolism, vitamin status, inflammation, and renal and endothelial function among cancer-free older adults

Zahed

¹

,

Johansson

²

,

Ueland

³

et al. 2021

Sci Rep

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…EFSA concluded that data on choline intake and risk of CVD cannot be used to derive DRVs for choline (3). This is supported by results from recent prospective cohort studies, showing no associations between choline intake and risk of total CVD, coronary heart disease, stroke, or atrial fibrillation (75)(76)(77).…”

Section: Cardiovascular Disease Incidence and Mortalitysupporting

confidence: 66%

Choline – a scoping review for Nordic Nutrition Recommendations 2023

Obeid

¹

,

Karlsson

²

2023

Food & Nutrition Research

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Similar results were found in a cohort in San Diego, California, [26] and the EPIC-Norfolk cohort [27]. In a nested matched case-control study using data from the Nurses' Health Study (NHS, 1990(NHS, -2010) and the Health Professionals Follow-up Study (HPFS, 1986(HPFS, -2010, higher homocysteine levels were positively associated with risk of PAD in men [28]. Recently, vitamin D defi ciency has been considered an independent risk factor for the development of PAD [29].…”

Section: Comparison With Other Studiessupporting

confidence: 59%

The risk of peripheral artery disease in older adults - seven-year results of the getABI study

Krause

¹

,

Burghaus

²

,

Thiem

³

et al. 2016

Vasa

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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