Journal of Molecular and Cellular Cardiology
 2015
DOI: 10.1016/j.yjmcc.2015.04.003
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Resolvin D1 activates the inflammation resolving response at splenic and ventricular site following myocardial infarction leading to improved ventricular function

Vasundhara Kain
1
,
Kevin A. Ingle
2
,
Romain A. Colas
3
et al.

Abstract: Unresolved inflammation is a major contributor to the development of heart failure following myocardial infarction (MI). Pro-resolving lipid mediators, such as resolvins (e.g. RvD1), are biosynthesized endogenously. The role of RvD1 in resolving post-MI inflammation has not been elucidated due to its unstable nature. Here, we have tested the role for two forms of RvD1, after incorporation into liposomes (Lipo-RvD1) and its free acid form (RvD1) in left ventricle (LV) and splenic remodeling post-MI. 8 to 12-wee… Show more

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Cited by 223 publications

(224 citation statements)
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“…Consistent with our earlier report, neutrophil swarming with formation of large aggregates was observed in the subpleural space under control conditions ( Fig. 2 A and Movie S1 ) ( 12 ). In contrast, lung grafts of recipients treated with the SPM mixture demonstrated a drastically reduced density of neutrophils, decreased extravasation and swarming, increased intravascular crawling velocities, as well as increased displacement ( Fig.…”
Section: Resultssupporting
confidence: 92%
“…Both RvD1 and Mar1 were increased in the bronchoalveolar lavage fluid of lung transplant patients at 7 d, but not at 24 h after engraftment. Similar observations were made in their mouse pulmonary clamp model where increased levels of RvD1 and Mar1 were noted in airway fluid at 24, but not 6 h after reperfusion ( 12 ). These findings compare with our observations in human and mouse lung transplant recipients where the tissue levels of SPMs are increased substantially early after reperfusion.…”
Section: Discussionsupporting
confidence: 76%
See 1 more Smart Citation
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Consistent with our earlier report, neutrophil swarming with formation of large aggregates was observed in the subpleural space under control conditions ( Fig. 2 A and Movie S1 ) ( 12 ). In contrast, lung grafts of recipients treated with the SPM mixture demonstrated a drastically reduced density of neutrophils, decreased extravasation and swarming, increased intravascular crawling velocities, as well as increased displacement ( Fig.…”
Section: Resultssupporting
confidence: 92%
“…Both RvD1 and Mar1 were increased in the bronchoalveolar lavage fluid of lung transplant patients at 7 d, but not at 24 h after engraftment. Similar observations were made in their mouse pulmonary clamp model where increased levels of RvD1 and Mar1 were noted in airway fluid at 24, but not 6 h after reperfusion ( 12 ). These findings compare with our observations in human and mouse lung transplant recipients where the tissue levels of SPMs are increased substantially early after reperfusion.…”
Section: Discussionsupporting
confidence: 76%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…RvD1 reduced intramuscular PMNs at day 3 of recovery, however. Consistent with our findings, prior studies showed no reduction in response to RvD1 of peak PMN infiltration of cardiac muscle following myocardial infarction but an accelerated PMN egress (37,38). Overall, these data are consistent with the notion that in addition to their antiinflammatory actions, SPMs actively promote PMN clearance, thus accelerating resolution to a noninflamed state (39).…”
Section: Discussionsupporting
confidence: 92%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Increases in proresolution marker arginase-1 in the MI border zone and CD206 surface levels in global cardiac macrophage populations from post-MI mouse hearts were observed with BMS-986235 treatment. These findings are consistent with the proresolution stimulatory effects of endogenous proresolution ligands ( 34 , 35 ). Together, these findings support the concept that FPR2 activation by BMS-986235 can potentiate proresolution activities via effects on neutrophil and macrophage populations.…”
Section: Discussionsupporting
confidence: 88%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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