Differential effects of estrogen and progesterone on development of primate secondary follicles in a steroid-depleted milieu<i>in vitro</i>

Ting, Alison Y.; Xu, Jing; Stouffer, Richard L.

doi:10.1093/humrep/dev119

Hum. Reprod.

2015

DOI: 10.1093/humrep/dev119

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Differential effects of estrogen and progesterone on development of primate secondary follicles in a steroid-depleted milieuin vitro

Alison Y. Ting

¹

,

Jing Xu

²

,

Richard L. Stouffer

³

Abstract: NIH P50 HD071836 (NCTRI), NIH ORWH/NICHD 2K12HD043488 (BIRCWH), ONPRC 8P51OD011092. There are no conflicts of interest.

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Cited by 48 publications

(37 citation statements)

References 74 publications

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Mentioning

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“…The increased CYP19A1 mRNA levels may be due to overexposure of follicles to FSH during culture, which is consistent with the observation that FSH stimulated the proliferation of granulosa cells, as well as their CYP19A1 expression and estradiol secretion [30]. The change in steroid (e.g., progesterone, androgen, and estrogen) production may affect subsequent follicular growth and oocyte maturation in vitro [12,26]. Therefore, the culture conditions need to be further improved to optimize granulosa and theca cell proliferation and differentiation in antral follicles to facilitate proper steroidogenic function and oocyte maturation that mimics in vivo follicular development.…”

Section: Discussionsupporting

confidence: 81%

Anti-Müllerian hormone is produced heterogeneously in primate preantral follicles and is a potential biomarker for follicle growth and oocyte maturation in vitro

Xu

¹

,

Xu

²

,

Letaw

³

et al. 2016

J Assist Reprod Genet

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…The increased CYP19A1 mRNA levels may be due to overexposure of follicles to FSH during culture, which is consistent with the observation that FSH stimulated the proliferation of granulosa cells, as well as their CYP19A1 expression and estradiol secretion [30]. The change in steroid (e.g., progesterone, androgen, and estrogen) production may affect subsequent follicular growth and oocyte maturation in vitro [12,26]. Therefore, the culture conditions need to be further improved to optimize granulosa and theca cell proliferation and differentiation in antral follicles to facilitate proper steroidogenic function and oocyte maturation that mimics in vivo follicular development.…”

Section: Discussionsupporting

confidence: 81%

Anti-Müllerian hormone is produced heterogeneously in primate preantral follicles and is a potential biomarker for follicle growth and oocyte maturation in vitro

Xu

¹

,

Xu

²

,

Letaw

³

et al. 2016

J Assist Reprod Genet

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Exogenous steroid and AMH concentrations were equivalent to those tested previously in a FSH-replete milieu (Rodrigues et al, 2015;Ting et al, 2015;Xu et al, 2016b). While a 10-fold higher E2 concentration was used in Experiment 2 compared to Experiment 1, both doses are within physiological ranges (100 pg/ml used in Experiment 1 is equivalent to circulating E2 levels while 1000 pg/ml used in Experiment 2 is equivalent to E2 levels found in follicular fluid in the rhesus macaque).…”

Section: Experiments 2: Estrogen And/or Androgen Replacementsupporting

confidence: 65%

“…In our previous reports, E2 alone (Ting et al, 2015) was as effective as DHT (Rodrigues et al, 2015) in promoting survival and growth of macaque preantral follicles in vitro in the presence of FSH. In the current report, the pro-survival and growth effect of E2 effects appeared somewhat less than those of DHT alone, with the latter's effects comparable to E2 plus DHT (% survival, antrum formation) and/or controls (% survival).…”

Section: Discussionmentioning

confidence: 77%

Direct actions of androgen, estrogen and anti-Müllerian hormone on primate secondary follicle development in the absence of FSH in vitro

Baba

¹

,

Ting

²

,

Tkachenko

³

et al. 2017

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…When main effects are significant, different lower case letters indicate significant differences between individual groups; asterisks (* vs **) denote trend towards differences. When no symbols are present, there were no differences detected by pairwise comparisons androgen (~6 years) [41,42]. In this previous study, we also observed increased numbers of atretic small antral follicles in vivo and increased numbers of degenerating oocytes following follicle culture after WSD and T+WSD treatments.…”

Section: Discussionsupporting

confidence: 45%

Chronically elevated androgen and/or consumption of a Western-style diet impairs oocyte quality and granulosa cell function in the nonhuman primate periovulatory follicle

Bishop

¹

,

Reiter

²

,

Erikson

³

et al. 2019

J Assist Reprod Genet

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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