Hum. Reprod. Update
 2016
DOI: 10.1093/humupd/dmw001
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Trends in ‘poor responder’ research: lessons learned from RCTs in assisted conception

Athanasios Papathanasiou
1
,
Belinda J. Searle2,
Nicole M.King
3
et al.

Abstract: Overall, the majority of published trials on POR suffer from methodological flaws and are, thus, regarded as being high-risk for bias. The same trials have used a variety of definitions for their poor responders and a variety of interventions for their head-to-head comparisons. Not surprisingly, discrepancies are also evident in the findings of trials comparing similar interventions. Based on the identified deficiencies, this novel type of 'methodology and clinical' review has introduced custom recommendations… Show more

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Cited by 77 publications

(52 citation statements)
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“…However, although the pharmacological approach to ART is evaluated, no publication biases are evident at funnel plots analyses (data not shown). As highlighted by previous meta-analyses, we found high selection and allocation biases, confirming the finding that more than 80% of clinical trials did not apply any blinding technique (50). This high percentage is probably due to the difficulty in applying these procedures to ART, in which over 30 therapeutic complex approaches are currently available.…”
Section: Discussionsupporting
confidence: 89%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…However, although the pharmacological approach to ART is evaluated, no publication biases are evident at funnel plots analyses (data not shown). As highlighted by previous meta-analyses, we found high selection and allocation biases, confirming the finding that more than 80% of clinical trials did not apply any blinding technique (50). This high percentage is probably due to the difficulty in applying these procedures to ART, in which over 30 therapeutic complex approaches are currently available.…”
Section: Discussionsupporting
confidence: 89%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…A prior research study like the current research in approach and methodology have revealed that young cases having diminished ovarian reserve issues could have a higher clinical probability of clinical pregnancy achievement than those with other etiologies. Furthermore in a similar manner to the current research study results they have shown that the serum FSH concentration levels in young aged diminished ovarian reserve cases was relatively lower than in other research groups and they had higher rates of implantation and pregnancy in comparison and contrast to other research groups those results verify the current research study results in those aspects an interesting fact was observed at molecular and cellular levels of research that justifies most of the current research study findings that ovarian biological aging could occur independent of chronological age [8,11].…”
Section: Discussionsupporting
confidence: 85%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…POR represent a challenging group of patients 25,28 , and the present study showed that there is no benefit of the freeze-all policy over fresh ET in POR patients undergoing the GnRH antagonist protocol for COS. Nowadays, there is evidence of increasing prevalence of POR 29 with a poor IVF prognosis [20][21][22] . In the present study, IRs were lower than 10%, both in the fresh ET and freeze-all groups, in accordance with previous studies published on POR [20][21][22][23]30 .…”
Section: Discussionmentioning
confidence: 59%
“…POR represent a challenging group of patients, and the present study showed that there is no benefit of the freeze‐all policy over fresh ET in POR patients undergoing the GnRH antagonist protocol for COS.…”
Section: Discussionmentioning
confidence: 62%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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