Altered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold Exposure

Ziętak, Marika; Kovatcheva‐Datchary, Petia; Markiewicz, Lidia Hanna; Ståhlman, Marcus; Kozak, Leslie P.; Bäckhed, Fredrik

doi:10.1016/j.cmet.2016.05.001

Cell Metabolism

2016

DOI: 10.1016/j.cmet.2016.05.001

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Altered Microbiota Contributes to Reduced Diet-Induced Obesity upon Cold Exposure

Marika Ziętak

¹

,

Petia Kovatcheva‐Datchary

²

,

Lidia Hanna Markiewicz

³

et al.

Abstract: SummaryMaintenance of body temperature in cold-exposed animals requires induction of thermogenesis and management of fuel. Here, we demonstrated that reducing ambient temperature attenuated diet-induced obesity (DIO), which was associated with increased iBAT thermogenesis and a plasma bile acid profile similar to that of germ-free mice. We observed a marked shift in the microbiome composition at the phylum and family levels within 1 day of acute cold exposure and after 4 weeks at 12°C. Gut microbiota was chara… Show more

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Cited by 368 publications

(269 citation statements)

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“…Levels of these markers showed already higher expression at first PCR+ time point with respect to their baseline, but peaked at 3-10 days after infection. IL-8 and CCL3 which have been reported as COVID-19 severity markers ( 21 , 37 – 39 ) and TNF-β was found in less severe disease ( 9 ), which is in agreement with our findings.…”

Section: Resultssupporting

confidence: 93%

Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19

Soares‐Schanoski

¹

,

Sauerwald

²

,

Goforth

³

et al. 2022

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Levels of these markers showed already higher expression at first PCR+ time point with respect to their baseline, but peaked at 3-10 days after infection. IL-8 and CCL3 which have been reported as COVID-19 severity markers ( 21 , 37 – 39 ) and TNF-β was found in less severe disease ( 9 ), which is in agreement with our findings.…”

Section: Resultssupporting

confidence: 93%

Asymptomatic SARS-CoV-2 Infection Is Associated With Higher Levels of Serum IL-17C, Matrix Metalloproteinase 10 and Fibroblast Growth Factors Than Mild Symptomatic COVID-19

Soares‐Schanoski

¹

,

Sauerwald

²

,

Goforth

³

et al. 2022

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Simpson index, an indicator of alpha diversity, was significantly decreased when the rats were intermittently exposed to severe cold (Additional file 1 : Fig. S3A), which was consistent with the previous report [ 38 ]. On the contrary, AA treatment increased the Simpson index although there was no statistical significance (Additional file 1 : Fig.…”

Section: Resultssupporting

confidence: 91%

Aqueous extracts of Aconite promote thermogenesis in rats with hypothermia via regulating gut microbiota and bile acid metabolism

Liu

¹

,

Tan

²

,

Ao

³

et al. 2021

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Relative abundance plots illustrate the composition of the microbiota in each group over time ( Figure 5A and Table S1 ) ( Shreiner et al., 2015 ). Prominent in the Chow-fed group were members of four well known bacterial phyla: Firmicutes (60 ± 8.5%), Bacteroidetes (33.460 ± 7.1%), Proteobacteria (1.675 ± 0.2%), and Actinobacteria (1.012 ± 0.2%), at day 0, consistent with previous reports ( David et al., 2014 ; Ziętak et al., 2016 ). The microbial composition remained relatively stable throughout the 12 week experiment for mice fed a Chow diet.…”

Section: Resultssupporting

confidence: 91%

Integrative Longitudinal Analysis of Metabolic Phenotype and Microbiota Changes During the Development of Obesity

Higgins

¹

,

Woodie

²

,

Hallowell

³

et al. 2021

Front. Cell. Infect. Microbiol.

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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