Immuno-oncology combinations: raising the tail of the survival curve

Harris, S.J.; Brown, Jessica; Lopez, Juanita; Yap, Timothy A.

doi:10.20892/j.issn.2095-3941.2016.0015

Cancer Biology and Medicine

2016

DOI: 10.20892/j.issn.2095-3941.2016.0015

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Immuno-oncology combinations: raising the tail of the survival curve

S.J. Harris

¹

,

Jessica Brown

²

,

Juanita Lopez

³

et al.

Abstract: There have been exponential gains in immuno-oncology in recent times through the development of immune checkpoint inhibitors. Already approved by the U.S. Food and Drug Administration for advanced melanoma and non-small cell lung cancer, immune checkpoint inhibitors also appear to have significant antitumor activity in multiple other tumor types. An exciting component of immunotherapy is the durability of antitumor responses observed, with some patients achieving disease control for many years. Nevertheless, n… Show more

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Cited by 104 publications

(81 citation statements)

References 145 publications

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“…Furthermore, transcriptome analysis of tumor‐infiltrating immune cells in mice treated with the combination therapy revealed that this treatment also reduced the expression of the inflammatory cytokine interleukin‐6 (IL‐6), angiogenic factor vascular endothelial growth factor A (VEGFA), and immunosuppressive enzyme arginase [ 44 , 45 , 46 , 47 ]. These immune‐activating effects collectively resulted in significant tumor reduction and long‐term “tail‐of‐the‐curve” survival benefits in tumor‐bearing mice, as demonstrated in our study and in previous studies [ 18 , 19 , 20 , 21 , 48 , 49 ].…”

Section: Discussionsupporting

confidence: 86%

A Combinatorial Effect of Immune Checkpoint Inhibitors and CD40 Agonistic Antibody in Murine Pancreatic Cancer Model

Ichikawa

¹

,

Okuda

²

,

Kawano

³

et al. 2025

Cancer Science

0

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Furthermore, transcriptome analysis of tumor‐infiltrating immune cells in mice treated with the combination therapy revealed that this treatment also reduced the expression of the inflammatory cytokine interleukin‐6 (IL‐6), angiogenic factor vascular endothelial growth factor A (VEGFA), and immunosuppressive enzyme arginase [ 44 , 45 , 46 , 47 ]. These immune‐activating effects collectively resulted in significant tumor reduction and long‐term “tail‐of‐the‐curve” survival benefits in tumor‐bearing mice, as demonstrated in our study and in previous studies [ 18 , 19 , 20 , 21 , 48 , 49 ].…”

Section: Discussionsupporting

confidence: 86%

A Combinatorial Effect of Immune Checkpoint Inhibitors and CD40 Agonistic Antibody in Murine Pancreatic Cancer Model

Ichikawa

¹

,

Okuda

²

,

Kawano

³

et al. 2025

Cancer Science

0

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…One of the key goals for future immunotherapy strategy is to "raise the tail" of the survival curve. 35 Our findings underscore the relevance of an early immunological biomarker response to the overall survival benefit and its potential utility as an early readout to inform dose and treatment decisions in drug development and clinical practice. The analyses performed by Bruno et al 36 indicate the correlation of tumor growth rate (K growth ) estimated by TGI models as a good predictor of survival.…”

Section: Discussionmentioning

confidence: 63%

APK/PDAnalysis of Circulating Biomarkers and Their Relationship to Tumor Response in Atezolizumab‐Treated non‐small Cell Lung Cancer Patients

Netterberg

¹

,

Li²,

Molinero³

et al. 2018

Clin Pharma and Therapeutics

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Immunotherapy is given with the aim of gaining durable disease control [19]. This study provides evidence that the likelihood of achieving disease control is similar between patients with acral cutaneous melanoma and those with non-acral cutaneous melanoma.…”

Section: Discussionmentioning

confidence: 73%

Safety and efficacy of nivolumab in patients with rare melanoma subtypes who progressed on or after ipilimumab treatment: a single-arm, open-label, phase II study (CheckMate 172)

Nathan

¹

,

Ascierto

²

,

Haanen

³

et al. 2019

European Journal of Cancer

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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