Front. Med.
 2017
DOI: 10.3389/fmed.2017.00039
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Imprecision in the Era of Precision Medicine in Non-Small Cell Lung Cancer

Raghav Sundar
1
,
Maxime Chénard-Poirier
2
,
Dearbhaile Catherine Collins
3
et al.

Abstract: Over the past decade, major advances have been made in the management of advanced non-small cell lung cancer (NSCLC). There has been a particular focus on the identification and targeting of putative driver aberrations, which has propelled NSCLC to the forefront of precision medicine. Several novel molecularly targeted agents have now achieved regulatory approval, while many others are currently in late-phase clinical trial testing. These antitumor therapies have significantly impacted the clinical outcomes of… Show more

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Cited by 22 publications

(18 citation statements)
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“…the neoadjuvant approach also paves the route for the design of clinical trials incorporating novel agents to allow for quicker in vivo and early read out of efficacy. Compared to breast cancer and lung cancer, which have had a rapid increase in survival due to the identification of novel targets and pathways, colon cancer treatment has significantly lagged behind in the field of precision oncology (40,41).…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…the neoadjuvant approach also paves the route for the design of clinical trials incorporating novel agents to allow for quicker in vivo and early read out of efficacy. Compared to breast cancer and lung cancer, which have had a rapid increase in survival due to the identification of novel targets and pathways, colon cancer treatment has significantly lagged behind in the field of precision oncology (40,41).…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The molecular diagnosis of mutations in EGFR exons 18, 19, 20 and 21 is recommended in all patients with advanced NSCLC, since TKI therapy provides significant improvement in survival and quality of life. 4 5 Most NSCLCs are diagnosed at an advanced disease stage, when surgery is not an option. Therefore, in more than 85% of cases, the clinical management of patients with NSCLC must rely on diagnostic procedures carried out on tissue samples obtained through minimally invasive procedures, that is, small biopsies or cytology sampling.…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Yes-associated protein (Yap) is a 65 kDa proline-rich phosphoprotein, which is located at locus 11q22 ( 48 ). A previous study reported that YAP may have oncogenic functions, and elevated YAP expression is associated with malignant tumors ( 21 , 49 ). In the present study, we found that Yap expression is increased in gastric cancer when compared to that noted in normal gastric mucosal cells.…”
Section: Discussionmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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