Journal of the American College of Cardiology
 2017
DOI: 10.1016/j.jacc.2017.08.006
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A Test in Context: Lipid Profile, Fasting Versus Nonfasting

Børge G. Nordestgaard
1

Abstract: Fasting for >8 h, as previously required for lipid profiles, normally only occurs a few hours before breakfast. By contrast, the nonfasting state predominates most of a 24-h cycle and better captures atherogenic lipoprotein levels. Plasma contains atherogenic lipoproteins of hepatic origin in the fasting state and additionally those of intestinal origin in the nonfasting state. Maximal mean changes for random, nonfasting versus fasting levels are +26 mg/dl for triglycerides, -8 mg/dl for total cholesterol, -8 … Show more

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Cited by 200 publications

(148 citation statements)
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“…The above results indicated that non-fasting lipid profile could be considered to evaluate 10-year CVD risk via China ASCVD risk estimator and Europe SCORE risk charts in clinical practice, but, the latter one may overestimate CVD risk in Chinese general population. Non-fasting lipid profiles changes in this study, especially LDL-C and TG, were relatively different from Denmark's studies, which showed insignificant changes after a daily meal, and maximal mean changes between non-fasting versus fasting blood samples as measured in random are +0.3 mmol/L for TG level and −0.2 mmol/L for TC and LDL-C (5,6,27,28). However, TC and LDL-C levels decreased by 0.3 and 0.7 mmol/L, respectively, while TG level increased by 0.6 mmol/L at 4 h after a daily breakfast in this study.…”
Section: Discussioncontrasting
confidence: 97%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…The above results indicated that non-fasting lipid profile could be considered to evaluate 10-year CVD risk via China ASCVD risk estimator and Europe SCORE risk charts in clinical practice, but, the latter one may overestimate CVD risk in Chinese general population. Non-fasting lipid profiles changes in this study, especially LDL-C and TG, were relatively different from Denmark's studies, which showed insignificant changes after a daily meal, and maximal mean changes between non-fasting versus fasting blood samples as measured in random are +0.3 mmol/L for TG level and −0.2 mmol/L for TC and LDL-C (5,6,27,28). However, TC and LDL-C levels decreased by 0.3 and 0.7 mmol/L, respectively, while TG level increased by 0.6 mmol/L at 4 h after a daily breakfast in this study.…”
Section: Discussioncontrasting
confidence: 97%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Non-fasting changes in lipid pro les, especially LDL-C and TG, in Chinese participants in this study were relatively different from those in other studies with large population in Denmark, which showed that changes in lipid pro les were insigni cant after a daily meal [6,[31][32][33]. The maximal mean changes between non-fasting versus fasting blood samples as measured in random are + 0.3 mmol/l for TG level and − 0.2 mmol/l for TC or LDL-C level [33]. However, TC and LDL-C levels decreased by 0.3 and 0.7 mmol/l, respectively, while TG level increased by 0.6 mmol/l at 4 h after a daily breakfast in this study.…”
Section: Discussioncontrasting
confidence: 95%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…It has been reported that food withdrawal caused a decrease in overnight fasting serum fatty acid metabolism, including SFA, MUFA, and PUFA in mice [ 59 ]. In this study, if we considered the birds fasted for 12 h as the control group, and the results aligned well with the previous work conducted in mice [ 60 ]. Furthermore, our results provide new evidence for recent guidelines that endorse non-fasting profiles for blood sampling [ 22 , 60 , 61 ].…”
Section: Discussionsupporting
confidence: 89%
“…In this study, if we considered the birds fasted for 12 h as the control group, and the results aligned well with the previous work conducted in mice [ 60 ]. Furthermore, our results provide new evidence for recent guidelines that endorse non-fasting profiles for blood sampling [ 22 , 60 , 61 ].…”
Section: Discussionsupporting
confidence: 89%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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