Osimertinib in Untreated
            <i>EGFR</i>
            -Mutated Advanced Non–Small-Cell Lung Cancer

Soria, Jean‐Charles; Ohe, Yuichiro; Vansteenkiste, Johan; Reungwetwattana, Thanyanan; Chewaskulyong, Busyamas; Lee, Ki Hyeong; Dechaphunkul, Arunee; Imamura, Fumio; Nogami, Naoyuki; Kurata, Takayasu; Okamoto, Isamu; Zhou, Caicun; Cho, Byoung Chul; Cheng, Ying; Cho, Eun Kyung; Voon, Pei Jye; Planchard, David; Su, Wu‐Chou; Gray, Jhanelle E.; Lee, Siow Ming; Hodge, Rachel; Marotti, Marcelo; Rukazenkov, Yuri; Ramalingam, Suresh S.

doi:10.1056/nejmoa1713137

N Engl J Med

2018

DOI: 10.1056/nejmoa1713137

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Osimertinib in Untreated EGFR -Mutated Advanced Non–Small-Cell Lung Cancer

Jean‐Charles Soria

¹

,

Yuichiro Ohe

²

,

Johan Vansteenkiste

³

et al.

Abstract: Osimertinib showed efficacy superior to that of standard EGFR-TKIs in the first-line treatment of EGFR mutation-positive advanced NSCLC, with a similar safety profile and lower rates of serious adverse events. (Funded by AstraZeneca; FLAURA ClinicalTrials.gov number, NCT02296125 .).

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Cited by 5,038 publications

(4,719 citation statements)

References 32 publications

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“…The present study also showed that the possibility of serious adverse events of third‐generation EGFR‐TKIs was significantly higher than that of first‐generation drugs, which was inconsistent with the results of previous study 13,40 . Looking back on the studies included in the analysis of adverse events comparing EGFR‐TKIs and placebo, the experiment design of Li et al was different from that in the ADAURA and RADIANT studies.…”

Section: Discussioncontrasting

confidence: 99%

The role of EGFR‐TKIs as adjuvant therapy in EGFR mutation‐positive early‐stage NSCLC: A meta‐analysis

Lin

¹

,

Hu

²

,

Chu

³

et al. 2021

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…The present study also showed that the possibility of serious adverse events of third‐generation EGFR‐TKIs was significantly higher than that of first‐generation drugs, which was inconsistent with the results of previous study 13,40 . Looking back on the studies included in the analysis of adverse events comparing EGFR‐TKIs and placebo, the experiment design of Li et al was different from that in the ADAURA and RADIANT studies.…”

Section: Discussioncontrasting

confidence: 99%

The role of EGFR‐TKIs as adjuvant therapy in EGFR mutation‐positive early‐stage NSCLC: A meta‐analysis

Lin

¹

,

Hu

²

,

Chu

³

et al. 2021

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…These results suggest that gefitinib has high cytotoxic effects on only H3255 cells with the L858R mutation, and osimertinib has high cytotoxic effects on H3255 cells and H1975 cells with L858R/T790M double mutations. These results are consistent with previous reports and clinical uses. , As we expected, 9 and 15 have higher cytotoxic effects on H3255 and H1975 than on H441 expressed with the wild-type EGFR. Particularly, 9 and 15 showed similar cytotoxic effects to osimertinib.…”

Section: Resultssupporting

confidence: 93%

Development of Radiohalogenated Osimertinib Derivatives as Imaging Probes for Companion Diagnostics of Osimertinib

Mishiro

¹

,

Nishii

²

,

Sawazaki

³

et al. 2022

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…4 B). These results indicate that the clinical efficacy of osimertinib for patients with EGFR -mutant NSCLC with brain metastases is equal to or greater than that of the other EGFR-TKIs, and our analyzed data were consistent with the previous reports of the FLAURA trial [ 17 , 18 ]. Furthermore, in patients with bone metastasis, the PFS of the osimertinib group was significantly longer than that of the gefitinib/erlotinib group (17.0 vs. 8.6 months; Wilcoxon P < 0.0001 and log-rank P < 0.0001; Fig.…”

Section: Resultssupporting

confidence: 92%

Clinical efficacy of osimertinib in EGFR-mutant non-small cell lung cancer with distant metastasis

Gen

¹

,

Tanaka

²

,

Morise

³

et al. 2022

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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