Therapeutic Charm of Quercetin and Its Derivatives: a Review of Research and Patents

Sharma, Ajay; Kashyap, Dharambir; Sak, Katrin; Tuli, Hardeep Singh; Sharma, Anil Kumar

doi:10.4155/ppa-2017-0030

Pharm. Pat. Anal.

2017

DOI: 10.4155/ppa-2017-0030

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Therapeutic Charm of Quercetin and Its Derivatives: a Review of Research and Patents

Ajay Sharma

¹

,

Dharambir Kashyap

²

,

Katrin Sak

³

et al.

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Cited by 131 publications

(58 citation statements)

References 35 publications

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“…In the studied extracts, the presence of quercetin was confirmed, which reflects three important findings: (i) it could be a common compound present in P. matricarioides independent of locality of cultivation, (ii) it can be used as marker component in different collections, and (iii) it is a metabolite with known medicinal value [24,25,26,27], which suggests the need for further pharmacological screening of P. matricarioides -derived products. However, the metabolite maps of the extracts showed the accumulation patterns of quercetin to be different, also suggesting the need for further bioactivity screening.…”

Section: Discussionmentioning

confidence: 56%

Comparative Pharmacognosy, Chemical Profile and Antioxidant Activity of Extracts from Phania matricarioides (Spreng.) Griseb. Collected from Different Localities in Cuba

Gaitén

¹

,

Scull

²

,

Monzote

³

et al. 2018

Plants

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…In the studied extracts, the presence of quercetin was confirmed, which reflects three important findings: (i) it could be a common compound present in P. matricarioides independent of locality of cultivation, (ii) it can be used as marker component in different collections, and (iii) it is a metabolite with known medicinal value [24,25,26,27], which suggests the need for further pharmacological screening of P. matricarioides -derived products. However, the metabolite maps of the extracts showed the accumulation patterns of quercetin to be different, also suggesting the need for further bioactivity screening.…”

Section: Discussionmentioning

confidence: 56%

Comparative Pharmacognosy, Chemical Profile and Antioxidant Activity of Extracts from Phania matricarioides (Spreng.) Griseb. Collected from Different Localities in Cuba

Gaitén

¹

,

Scull

²

,

Monzote

³

et al. 2018

Plants

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Quercetin, kaempferol, and crytotanshinone were identified as the active ingredients involved in most targets, and the molecular docking outcomes also validated that they exhibit strong binding efficacy with STAT1, STAT3, and HIF1A. Quercetin is a promising natural dietary compound with preventive and therapeutic effects on a variety of diseases (Sharma et al, 2018), and its activities are embodied in antioxidant, anti-inflammatory, and proproliferative activities. The antioxidant and anti-inflammatory activities of quercetin in cerebral I/R treatment have been validated by various in vivo and in vitro studies.…”

Section: Discussionmentioning

confidence: 91%

Investigation into the potential mechanism and molecular targets of Fufang Xueshuantong capsule for the treatment of ischemic stroke based on network pharmacology and molecular docking

Wang

¹

,

Wang

²

,

Wang³

et al. 2022

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Rutoside, also known in the literature as rutin [ 11 , 282 , 283 ], isoquercitrin, and quercitrin are the most commonly occurring glycosidic forms of quercetin in nature [ 284 ]. It is considered that the saccharide group may change the solubility, absorption, and in vivo action of the quercetin molecule because, according to studies, aglyconic quercetin has low solubility in water.…”

Section: Resultsmentioning

confidence: 99%

“…Then, dihydroquercetin results, by hydroxylation reactions, in the positions C 3’ of dihydrokaempferol under the influence of flavonoid-3’-hydroxylase and C 3 of eriodyctiol under the influence of flavanon-3-hydroxylase. Further, dihydroquercetin [ 291 ] is converted under the influence of flavonol synthetase into quercetin, due to the formation of the double bond between C2 and C3 in the pyranic nucleus [ 283 ]. Flavanon 3-hydroxylase belongs to the family of enzymes known as dioxygenases.…”

Section: Resultsmentioning

confidence: 99%

A Systematic Review: Quercetin—Secondary Metabolite of the Flavonol Class, with Multiple Health Benefits and Low Bioavailability

Frenț

¹

,

Ștefan

²

,

Morgovan

³

et al. 2024

IJMS

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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