Differential effects of reticulophagy and mitophagy on nonalcoholic fatty liver disease

Pang, Lijun; Liu, Kai; Liu, Daojie; Lv, Fudong; Zang, Yunjin; Xie, Fang; Yin, Jiming; Shi, Ying; Wang, Yanjun; Chen, Dexi

doi:10.1038/s41419-017-0136-y

Cell Death Dis

2018

DOI: 10.1038/s41419-017-0136-y

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Differential effects of reticulophagy and mitophagy on nonalcoholic fatty liver disease

Lijun Pang

¹

,

Kai Liu

²

,

Daojie Liu

³

et al.

Abstract: Autophagy affects the pathological progression of non-alcoholic fatty liver disease (NAFLD); however, the precise role of autophagy in NAFLD remains unclear. In this study, we want to identify the role of autophagy including reticulophagy and mitophagy in NAFLD pathogenesis. When HepG2 cells were treated with 400 μM oleic acid (OA), increased reticulophagy was induced 8 h after treatment, which correlated with an anti-apoptotic response as shown by the activation of the PI3K/AKT pathway, an increase in BCL-2 e… Show more

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Cited by 48 publications

(40 citation statements)

References 68 publications

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“…Several studies have depicted a role for Akt in controlling hepatic steatosis through an mTOR-dependent mechanism. Elevated Akt phosphorylation was noted in livers from NAFLD patients alongside with dysregulated autophagy 53 . Akt activation, particular Akt2 was shown to foster hepatic steatosis through SREBP1c regulation, suggesting its therapeutic value in the management of NAFLD 23 , 54 .…”

Section: Discussionmentioning

confidence: 99%

Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy

Wang

¹

,

Tao

²

,

Chen

³

et al. 2021

Acta Pharmaceutica Sinica B

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Several studies have depicted a role for Akt in controlling hepatic steatosis through an mTOR-dependent mechanism. Elevated Akt phosphorylation was noted in livers from NAFLD patients alongside with dysregulated autophagy 53 . Akt activation, particular Akt2 was shown to foster hepatic steatosis through SREBP1c regulation, suggesting its therapeutic value in the management of NAFLD 23 , 54 .…”

Section: Discussionmentioning

confidence: 99%

Ablation of Akt2 and AMPKα2 rescues high fat diet-induced obesity and hepatic steatosis through Parkin-mediated mitophagy

Wang

¹

,

Tao

²

,

Chen

³

et al. 2021

Acta Pharmaceutica Sinica B

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…In MASLD, aberrant activation of PI3K/AKT promotes sustained lipid accumulation and cellular damage by inducing mitophagy. 30 Furthermore, studies have demonstrated that the PI3K/AKT signaling pathway plays a significant role in the initiation and progression of liver fibrosis. This pathway promotes the activation and proliferation of hepatic stellate cells (HSCs), leading to excessive deposition of extracellular matrix (ECM) components, thereby exacerbating the process of hepatic fibrosis.…”

Section: Discussionmentioning

confidence: 99%

Linking bisphenol a exposure to MASLD: insights from network toxicology and machine learning based on NHANES 2005–2012 data

Xu

¹

,

Gan

²

,

Zhao

³

2025

Toxicology Research

0

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Moreover, in early steatosis, accumulated lipids, including cholesterol and triglycerides, compromise hepatocyte stability. This progression is further driven by lipid imbalance, mitochondrial dysfunction, ER stress, and oxidative stress, eventually advancing to NASH with fibrosis ( Pang et al, 2018 ; Sanders and Griffin, 2016 ). Our study demonstrated that in both PA and HFD groups, there was an elevated expression of lipogenic genes (Fasn, Srebp1, Acc1, Scd1) and the fatty acid translocase Cd36, accompanied by significant increases in TG, TC, and LDL-C levels, and a decrease in HDL-C levels.…”

Section: Discussionmentioning

confidence: 99%

Metformin’s effect on metabolic dysfunction-associated steatotic liver disease through the miR-200a-5p and AMPK/SERCA2b pathway

Chen

¹

,

Huang

²

,

Zhang

³

et al. 2024

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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