Critical Reviews in Food Science and Nutrition
 2021
DOI: 10.1080/10408398.2021.1880363
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A narrative review on the potential of tomato and lycopene for the prevention of Alzheimer’s disease and other dementias

Federica Ratto
1
,
Flaminia Franchini
2
,
Massimo Musicco
3
et al.
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Cited by 40 publications

(23 citation statements)
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“…Supplementation with lycopene may improve cognitive function and reduce the risk of neurodegenerative disorders such as Alzheimer’s disease. The regular consumption of tomato products providing approximately 30 mg of lycopene per day over a period of several weeks has been demonstrated to engender improvements in oxidative stress markers, with the potential to support neuroprotection in older adults [ 125 ]. Lycopene is also recognized for its potential role in reducing the risk of certain cancers, with evidence supporting its efficacy against prostate cancer (where doses of 15–30 mg daily in humans, or 5–45 mg/kg diet in preclinical studies, administered over 8–12 weeks have shown significant protective effects) [ 126 ], lung cancer (where doses of 15–60 mg/day, particularly higher doses associated with a 3.4-fold increase in lung tissue concentration, have demonstrated benefits over durations of 8–14 weeks) [ 127 ], and stomach cancer (where daily intakes ranging from 5 to 10 mg for general protective effects to 15–30 mg for stronger preventive outcomes, sustained over several months, have been linked to significant reductions in risk) [ 128 ].…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Supplementation with lycopene may improve cognitive function and reduce the risk of neurodegenerative disorders such as Alzheimer’s disease. The regular consumption of tomato products providing approximately 30 mg of lycopene per day over a period of several weeks has been demonstrated to engender improvements in oxidative stress markers, with the potential to support neuroprotection in older adults [ 125 ]. Lycopene is also recognized for its potential role in reducing the risk of certain cancers, with evidence supporting its efficacy against prostate cancer (where doses of 15–30 mg daily in humans, or 5–45 mg/kg diet in preclinical studies, administered over 8–12 weeks have shown significant protective effects) [ 126 ], lung cancer (where doses of 15–60 mg/day, particularly higher doses associated with a 3.4-fold increase in lung tissue concentration, have demonstrated benefits over durations of 8–14 weeks) [ 127 ], and stomach cancer (where daily intakes ranging from 5 to 10 mg for general protective effects to 15–30 mg for stronger preventive outcomes, sustained over several months, have been linked to significant reductions in risk) [ 128 ].…”
Section: Resultsmentioning
confidence: 99%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…In vitro and in vivo studies demonstrated that pretreatment with lycopene reduced A β ‐induced cellular damage and prevented A β 1–42‐stimulated cellular apoptosis via the inhibition of ROS production (Ratto et al. 2022; Dias et al. 2014).…”
Section: Resultsmentioning
confidence: 99%
“…Carotenoid astaxanthin showed efficacy in the reducing of neurotoxicity induced by the Aβ fragments in cell culture models of AD (Lobos et al 2016;Wang et al 2010). In vitro and in vivo studies demonstrated that pretreatment with lycopene reduced Aβ-induced cellular damage and prevented Aβ 1-42-stimulated cellular apoptosis via the inhibition of ROS production (Ratto et al 2022;Dias et al 2014). However, numerous reports are available on synthetic or semisynthetic compounds containing long alkyl chains linked to nitrogen or sulfur together with moieties/heterocycles or positively charged groups like compounds 3, 4, and 5.…”
Section: Molecular Docking Of Compound 4 In the Active Site Of Acetyl...mentioning
confidence: 98%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
“…Lycopene also showed antidiabetic properties [37,50]. Research proves its beneficial effects in nervous system disorders, including neurodegenerative diseases such as Parkinson s disease and Alzheimer s disease [51][52][53][54]. The positive effect of lycopene has also been observed in liver diseases and ulcerative colitis [16,55].…”
Section: Lycopenementioning
confidence: 96%
Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.
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