Anastrozol

Anastrozol
Klinički podaci
Prodajno ime	Anastrole, Arimidex
Drugs.com	Monografija
Način primene	Oralno
Identifikatori
CAS broj	120511-73-1
ATC kod	L02BG03 (WHO)
PubChem	CID 2187
DrugBank	DB01217
ChemSpider	2102
KEGG	C08159
ChEBI	CHEBI:2704
ChEMBL	CHEMBL1399

Anastrozol je organsko jedinjenje, koje sadrži 17 atoma ugljenika i ima molekulsku masu od 293,366 Da.^[1]^[2]^[3]^[4]^[5]^[6]^[7]^[8]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	4
Broj donora vodonika	0
Broj rotacionih veza	4
Particioni koeficijent^[9] (ALogP)	3,0
Rastvorljivost^[10] (logS, log(mol/L))	-5,6
Polarna površina^[11] (PSA, Å²)	78,3

Reference

^ Howell, A.; Cuzick, J.; Baum, M.; Buzdar, A.; Dowsett, M.; Forbes, J. F.; Hoctin-Boes, G.; Houghton, J.; Locker, G. Y.; Tobias, J. S.; ATAC Trialists' Group (2005). „Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer”. Lancet (London, England). 365 (9453): 60—2. PMID 15639680. doi:10.1016/S0140-6736(04)17666-6.
^ Mauras N, Bishop K, Merinbaum D, Emeribe U, Agbo F, Lowe E: Pharmacokinetics and pharmacodynamics of anastrozole in pubertal boys with recent-onset gynecomastia. J Clin Endocrinol Metab. 2009 Aug;. 94 (8): 2975—8. PMID 19470631. Недостаје или је празан параметар |title= (помоћ). Epub 2009 May 26.
^ Nabholtz, J. M. (2006). „Role of anastrozole across the breast cancer continuum: From advanced to early disease and prevention”. Oncology. 70 (1): 1—12. PMID 16439860. doi:10.1159/000091180.
^ Milani, M.; Jha, G.; Potter, D. A. (2009). „Anastrozole Use in Early Stage Breast Cancer of Post-Menopausal Women”. Clinical Medicine. Therapeutics. 1: CMT.S9: 141—156. PMC 2753667 . PMID 19794821. doi:10.4137/cmt.s9.
^ Gangadhara S, Bertelli G: Long-term efficacy and safety of anastrozole for adjuvant treatment of early breast cancer in postmenopausal women. Ther Clin Risk Manag. 2009 Aug;. 5 (4): 291—300. PMID 19753124. Недостаје или је празан параметар |title= (помоћ). Epub 2009 May 4.
^ Santen RJ, Brodie H, Simpson ER, Siiteri PK, Brodie A: History of aromatase: saga of an important biological mediator and therapeutic target. Endocr Rev. 2009 Jun;. 30 (4): 343—75. PMID 19389994. Недостаје или је празан параметар |title= (помоћ). Epub 2009 Apr 23.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Anastrozole Архивирано на веб-сајту Wayback Machine (14. април 2014)

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Howell, A.; Cuzick, J.; Baum, M.; Buzdar, A.; Dowsett, M.; Forbes, J. F.; Hoctin-Boes, G.; Houghton, J.; Locker, G. Y.; Tobias, J. S.; ATAC Trialists' Group (2005). „Results of the ATAC (Arimidex, Tamoxifen, Alone or in Combination) trial after completion of 5 years' adjuvant treatment for breast cancer”. Lancet (London, England). 365 (9453): 60—2. PMID 15639680. doi:10.1016/S0140-6736(04)17666-6.

[2] Mauras N, Bishop K, Merinbaum D, Emeribe U, Agbo F, Lowe E: Pharmacokinetics and pharmacodynamics of anastrozole in pubertal boys with recent-onset gynecomastia. J Clin Endocrinol Metab. 2009 Aug;. 94 (8): 2975—8. PMID 19470631. Недостаје или је празан параметар |title= (помоћ). Epub 2009 May 26.

[3] Nabholtz, J. M. (2006). „Role of anastrozole across the breast cancer continuum: From advanced to early disease and prevention”. Oncology. 70 (1): 1—12. PMID 16439860. doi:10.1159/000091180.

[4] Milani, M.; Jha, G.; Potter, D. A. (2009). „Anastrozole Use in Early Stage Breast Cancer of Post-Menopausal Women”. Clinical Medicine. Therapeutics. 1: CMT.S9: 141—156. PMC 2753667 . PMID 19794821. doi:10.4137/cmt.s9.

[5] Gangadhara S, Bertelli G: Long-term efficacy and safety of anastrozole for adjuvant treatment of early breast cancer in postmenopausal women. Ther Clin Risk Manag. 2009 Aug;. 5 (4): 291—300. PMID 19753124. Недостаје или је празан параметар |title= (помоћ). Epub 2009 May 4.

[6] Santen RJ, Brodie H, Simpson ER, Siiteri PK, Brodie A: History of aromatase: saga of an important biological mediator and therapeutic target. Endocr Rev. 2009 Jun;. 30 (4): 343—75. PMID 19389994. Недостаје или је празан параметар |title= (помоћ). Epub 2009 Apr 23.

[7] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[8] Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[9] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[10] Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[11] Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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p r u Citostatici-antitumorski lekovi
Alkilirajuća sredstva	ciklofosfamid • ifosfamid • temozolomid • dakarbazin
Antimetaboliti	metotreksat • pemetreksed • kladribin • fludarabin • citarabin • fluorouracil • gemcitabin • kapecitabin
Protivtumorski antibiotici	doksorubicin • daunorubicin • idarubicin • bleomicin
Sredastva biljnog porekla	vinblastin • vinkristin • vinorelbin • etopozid • paklitaksel • docetaksel
Hormonski lekovi	megestrol • medroksiprogesteron • goserelin • triptorelin • tamoksifen • flutamid • nilutamid • bikalutamid • anastrozol • letrozol • eksemestan
Ostali najnoviji lekovi	cisplatin • karboplatin • oksaliplatin • rituksimab • alemtuzumab • cetuksimab • bevacizumab • imatinib • gefitinib • erlotinib • sorafenib • estramustin • tretinoin • bortezomib • anagrelid