Lenalidomid

Lenalidomid
Klinički podaci
Prodajno ime	Ladevina, Lenangio, Revlimid
Drugs.com	Monografija
Način primene	Oralno
Identifikatori
CAS broj	191732-72-6
ATC kod	L04AX04 (WHO)
PubChem	CID 216326
DrugBank	DB00480
ChemSpider	187515
ChEBI	CHEBI:63791
ChEMBL	CHEMBL848

Lenalidomid je organsko jedinjenje, koje sadrži 13 atoma ugljenika i ima molekulsku masu od 259,261 Da.^[1]^[2]^[3]^[4]^[5]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	4
Broj donora vodonika	2
Broj rotacionih veza	1
Particioni koeficijent^[6] (ALogP)	-0,5
Rastvorljivost^[7] (logS, log(mol/L))	-1,6
Polarna površina^[8] (PSA, Å²)	92,5

Reference

^ List A, Kurtin S, Roe DJ, Buresh A, Mahadevan D, Fuchs D, Rimsza L, Heaton R, Knight R, Zeldis JB (2005 Feb 10). „Efficacy of lenalidomide in myelodysplastic syndromes”. N Engl J Med. 352 (6): 549—57. PMID 15703420. doi:10.1056/NEJMoa041668. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Chang DH, Liu N, Klimek V, Hassoun H, Mazumder A, Nimer SD, Jagannath S, Dhodapkar MV: Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: therapeutic implications. Blood. Chang, D. H.; Liu, N.; Klimek, V.; Hassoun, H.; Mazumder, A.; Nimer, S. D.; Jagannath, S.; Dhodapkar, M. V. (2006 Jul 15). „Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: Therapeutic implications”. Blood. 108 (2): 618—21. PMC 1895497 . PMID 16569772. doi:10.1182/blood-2005-10-4184. Проверите вредност парамет(а)ра за датум: |date= (помоћ). Epub 2006 Mar 28.
^ Anderson KC: Lenalidomide and thalidomide: mechanisms of action--similarities and differences. Semin Hematol. 2005 Oct;42(4 Suppl 4):S3-8. Anderson, K. C. (2005). „Lenalidomide and thalidomide: Mechanisms of action--similarities and differences”. Seminars in Hematology. 42 (4 Suppl 4): S3—8. PMID 16344099. doi:10.1053/j.seminhematol.2005.10.001.
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Lenalidomide Архивирано на веб-сајту Wayback Machine (16. фебруар 2014)

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] List A, Kurtin S, Roe DJ, Buresh A, Mahadevan D, Fuchs D, Rimsza L, Heaton R, Knight R, Zeldis JB (2005 Feb 10). „Efficacy of lenalidomide in myelodysplastic syndromes”. N Engl J Med. 352 (6): 549—57. PMID 15703420. doi:10.1056/NEJMoa041668. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[2] Chang DH, Liu N, Klimek V, Hassoun H, Mazumder A, Nimer SD, Jagannath S, Dhodapkar MV: Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: therapeutic implications. Blood. Chang, D. H.; Liu, N.; Klimek, V.; Hassoun, H.; Mazumder, A.; Nimer, S. D.; Jagannath, S.; Dhodapkar, M. V. (2006 Jul 15). „Enhancement of ligand-dependent activation of human natural killer T cells by lenalidomide: Therapeutic implications”. Blood. 108 (2): 618—21. PMC 1895497 . PMID 16569772. doi:10.1182/blood-2005-10-4184. Проверите вредност парамет(а)ра за датум: |date= (помоћ). Epub 2006 Mar 28.

[3] Anderson KC: Lenalidomide and thalidomide: mechanisms of action--similarities and differences. Semin Hematol. 2005 Oct;42(4 Suppl 4):S3-8. Anderson, K. C. (2005). „Lenalidomide and thalidomide: Mechanisms of action--similarities and differences”. Seminars in Hematology. 42 (4 Suppl 4): S3—8. PMID 16344099. doi:10.1053/j.seminhematol.2005.10.001.

[4] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[5] Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[6] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[7] Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[8] Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

[8]