The last build I had not yet done has proved to be one of the most overpowered. I think plasma weapons have to rank second after ballistics for overall in-game OPness.

Along the way, I found a legendary two shot plasma rifle which I converted to a sniper rifle. Amazing. Only beaten by a gauss rifle or the Overseer's guardian for sniping goodness, but much easier to use than the gauss since you don't have to wait for it to charge up to get the full effect.

The plasma rifle with a flamer barrel mod is the perfect close quarters weapon and you can craft the mod with just the Science level 2 perk. When fully perked up with science and gun nut, it becomes a ghoul/insect close quarters destroyer.

I never managed to find one, if they even exist, but I think a plasma rifle with the explosive legendary effect would be a great long range main weapon.

Ballistic weapons remain my favorite because they are strong even early and when you find Cricket and get the Spray 'N Pray shotgun and then also the Overseer's Guardian, everything becomes easy mode.

My least favorite builds are heavy weapons and melee. HW are too inaccurate for my preferred stealthy sniper style and melee has that awful delay due to animation at the start of an attack which I just find annoying.