AlphaFold as a prior: experimental structure determination conditioned on a pretrained neural network
Machine learning has revolutionised structural biology, with tools like AlphaFold2 enabling rapid protein structure prediction from sequence alone. Yet challenges remain in modelling details such as...
A PTPN23-dependent ESCRT pathway is essential for constitutive secretion in mammalian cells
Our bodies are constantly producing and secreting thousands of proteins, from antibodies that fight infection, to the structural proteins holding tissues together, to the signalling molecules that go...
Recruitment of bifunctional regulator thermospermine to methylated ribosomes directs xylem fate
Polyamines are often associated with ribosomes and are thought to stabilise their integrity. However, no specific cellular functions have yet been attributed to ribosome-bound polyamines despite...
The MYO1F interactome reveals ASAP1, CD2AP and SH3KBP1 as novel adaptor proteins in podosomes and phagosomes
Within eukaryotic cells, myosin motor proteins move cargo over short distances along actin tracks, regulate plasma membrane dynamics through the actin cortex and provide flexible tethering of...
A structural basis for chaperone repression of stress signaling from the endoplasmic reticulum
Eukaryotes are endowed with signaling pathways that couple the burden of protein folding in the lumen of their endoplasmic reticulum (ER) to rectifying changes in gene expression, mRNA translation...
Coordination of autophagosome closure and release by the Alzheimer’s disease-associated protein BIN1
Autophagy is a key proteostasis pathway that maintains cytoplasmic quality control by recycling damaged and/or superfluous cellular organelles and proteins, including many aggregation-prone proteins...
PELP1 coordinates the modular assembly and enzymatic activity of the rixosome complex
The rixosome is a large multisubunit complex that initiates RNA decay during critical nuclear transactions including ribosome assembly and heterochromatin maintenance. The overall architecture of the...
The intracellular bacterium Orientia tsutsugamushi uses the autotransporter ScaC to activate BICD adaptors for dynein-based motility
The intracellular bacterium Orientia tsutsugamushi relies on the microtubule cytoskeleton and the motor protein dynein to traffic to the perinuclear region within infected cells. However, it remains...
Plasma membrane remodeling in GM2 gangliosidoses drives synaptic dysfunction
Glycosphingolipids (GSL) are important bioactive membrane components. GSLs containing sialic acids, known as gangliosides, are highly abundant in the brain and diseases of ganglioside metabolism...
We were delighted to welcome a group of undergraduate students from Anglia Ruskin University's Biomedical Science Society yesterday (13th April). Three of our PhD students, Holly Monkhouse, Ellie Fox...
We had a great time on Saturday at the Cambridge Festival's Biomedical Campus Open Day. Well over 1,000 visitors enjoyed activities and demonstrations from many of the research institutions...
Over the February half term CIMR, along with the Mitochondrial Biology Unit and for the first time the Institute of Metabolic Science, ran our ISACM work experience programme. We hosted 15 year 12...
