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Embryonic stem cell identity grounded in the embryo

Nature Cell Biology volume 16, pages 502–504 (2014) Cite this article

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Pluripotent embryonic stem cells (ESCs) can be derived from blastocyst-stage mouse embryos. However, the exact in vivo counterpart of ESCs has remained elusive. A combination of expression profiling and stem cell derivation identifies epiblast cells from late-stage blastocysts as the source, and functional equivalent, of ESCs.

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Figure 1: Direct in vitro capture of embryo-derived epiblast cells.
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Authors and Affiliations

  1. Berenika Plusa is in the Faculty of Life Sciences, The University of Manchester, Oxford Road, Manchester M13 9PT, UK,

    Berenika Plusa

  2. Anna-Katerina Hadjantonakis is in the Developmental Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA,

    Anna-Katerina Hadjantonakis

Authors
  1. Berenika Plusa
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  2. Anna-Katerina Hadjantonakis
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Correspondence to Berenika Plusa or Anna-Katerina Hadjantonakis.

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The authors declare no competing financial interests.

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Plusa, B., Hadjantonakis, AK. Embryonic stem cell identity grounded in the embryo. Nat Cell Biol 16, 502–504 (2014). https://doi.org/10.1038/ncb2984

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