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Synaptic plasticity and self-organization in the hippocampus

Nature Neuroscience volume 8, pages 1418–1420 (2005) Cite this article

A new paper reports that long-term potentiation in the hippocampus, a model of learning and memory, can induce sharp wave-ripple complexes, which are thought to be critical for the stabilization of memory traces in cortex.

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Figure 1: Self-organized burst of activity in the hippocampal CA3 region produces a field potential in the dendritic layer of CA1 and a short-lived fast-frequency field oscillation (200-Hz ripple) within stratum pyramidale, as well as a phase-related discharge of the neurons.
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References

  1. Behrens, J., van den Boom, L.P., de Hoz, L., Friedman, A. & Heinemann, U. Nat. Neurosci. 8, 1560–1567 (2005).

    Article  CAS  Google Scholar 

  2. Buzsaki, G. Neuroscience 31, 551–570 (1989).

    Article  CAS  Google Scholar 

  3. Chrobak, J.J. & Buzsaki, G. J. Neurosci. 14, 6160–6170 (1994).

    Article  CAS  Google Scholar 

  4. Klausberger, T. et al. Nature 421, 844–848 (2003).

    Article  CAS  Google Scholar 

  5. Csicsvari, J., Hirase, H., Czurko, A., Mamiya, A. & Buzsaki, G. J. Neurosci. 19, 274–287 (1999).

    Article  CAS  Google Scholar 

  6. Wilson, M.A. & McNaughton, B.L. Science 265, 676–679 (1994).

    Article  CAS  Google Scholar 

  7. Papatheodoropoulos, C. & Kostopoulos, G. Brain Res. Bull. 57, 187–193 (2002).

    Article  Google Scholar 

  8. Kubota, D., Colgin, L.L., Casale, M., Brucher, F.A. & Lynch, G. J. Neurophysiol. 89, 81–89 (2003).

    Article  Google Scholar 

  9. Yanovsky, Y., Brankack, J. & Haas, H.L. Neuroscience 64, 319–325 (1995).

    Article  CAS  Google Scholar 

  10. Maier, N. Nimmrich, & Draguhn, A. J. Physiol. (Lond.) 550, 873–887 (2003).

    Article  CAS  Google Scholar 

  11. Colgin, L.L., Jia, Y., Sabatier, J.M. & Lynch, G. Neurosci. Lett. 385, 46–51 (2005).

    Article  CAS  Google Scholar 

  12. LeBeau, F.E., Traub, R.D., Monyer, H., Whittington, M.A. & Buhl, E.H. Brain Res. Bull. 62, 3–13 (2003).

    Article  CAS  Google Scholar 

  13. King, C., Henze, D.A., Leinekugel, X. & Buzsaki, G. J. Physiol. (Lond.) 521, 159–167 (1999).

    Article  CAS  Google Scholar 

  14. Axmacher, N. & Miles, R. J. Physiol. (Lond.) 555, 713–725 (2004).

    Article  CAS  Google Scholar 

  15. Pouille, F. & Scanziani, M. Science 293, 1159–1163 (2001).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. the Center for Molecular and Behavioral Neuroscience, Rutgers, the State University of New Jersey, 197 University Avenue, Newark, 07102, New Jersey, USA

    György Buzsáki

  2. the Department of Psychology, University of Connecticut, 406 Babbidge Road, Storrs, 06269, Connecticut, USA

    James J Chrobak

Authors
  1. György Buzsáki
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  2. James J Chrobak
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Buzsáki, G., Chrobak, J. Synaptic plasticity and self-organization in the hippocampus. Nat Neurosci 8, 1418–1420 (2005). https://doi.org/10.1038/nn1105-1418

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