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BRCA1 (Q17487737)

From Wikidata
mammalian protein found in Homo sapiens
  • RING finger protein 53
  • breast cancer 1, early onset
  • protein phosphatase 1, regulatory subunit 53
  • early onset breast cancer 1
  • Fanconi anemia, complementation group S
  • breast and ovarian cancer susceptibility protein 1
  • BRCA1
  • BRCA1/BRCA2-containing complex, subunit 1
  • breast cancer type 1 susceptibility protein
  • BRCA1 Protein
  • BRCA1 DNA repair associated
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BRCA1
    English
    BRCA1
    mammalian protein found in Homo sapiens
    • RING finger protein 53
    • breast cancer 1, early onset
    • protein phosphatase 1, regulatory subunit 53
    • early onset breast cancer 1
    • Fanconi anemia, complementation group S
    • breast and ovarian cancer susceptibility protein 1
    • BRCA1
    • BRCA1/BRCA2-containing complex, subunit 1
    • breast cancer type 1 susceptibility protein
    • BRCA1 Protein
    • BRCA1 DNA repair associated

    Statements

    image
    Protein BRCA1 PDB 1jm7.png
    744 × 504; 188 KB
    0 references
    molecular function
    protein binding
    determination method or standard
    IPI
    64 references
    retrieved
    8 April 2019
    stated in
    EXD2 promotes homologous recombination by facilitating DNA end resection
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BRCA1 cooperates with NUFIP and P-TEFb to activate transcription by RNA polymerase II
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Highlight: BRCA1 and BRCA2 proteins in breast cancer
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CCDC98 targets BRCA1 to DNA damage sites
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The UBXN1 Protein Associates with Autoubiquitinated Forms of the BRCA1 Tumor Suppressor and Inhibits Its Enzymatic Function
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of DBC1 as a transcriptional repressor for BRCA1
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BRCA1 protein is linked to the RNA polymerase II holoenzyme complex via RNA helicase A
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    VCP, a weak ATPase involved in multiple cellular events, interacts physically with BRCA1 in the nucleus of living cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MERIT40 facilitates BRCA1 localization and DNA damage repair
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PALB2 is an integral component of the BRCA complex required for homologous recombination repair
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ATM activation by ionizing radiation requires BRCA1-associated BAAT1
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    KIAA0101 Interacts with BRCA1 and Regulates Centrosome Number
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CDK targets Sae2 to control DNA-end resection and homologous recombination
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The BRCT Domain Is a Phospho-Protein Binding Domain
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Mammalian SUMO E3-ligases PIAS1 and PIAS4 promote responses to DNA double-strand breaks
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Multifunctional transcription factor TFII-I is an activator of BRCA1 function
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of a RING protein that can interact in vivo with the BRCA1 gene product
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The SUMO modification pathway is involved in the BRCA1 response to genotoxic stress.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The interaction of PP1 with BRCA1 and analysis of their expression in breast tumors
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Functional interaction of BRCA1-associated BARD1 with polyadenylation factor CstF-50
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interaction between the helicases genetically linked to Fanconi anemia group J and Bloom's syndrome
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Identification of a Novel Cytoplasmic Protein That Specifically Binds to Nuclear Localization Signal Motifs
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Bcl-2 inhibits nuclear homologous recombination by localizing BRCA1 to the endomembranes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Function of BRCA1 in the DNA Damage Response Is Mediated by ADP-Ribosylation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    FANCJ/BACH1 Acetylation at Lysine 1249 Regulates the DNA Damage Response
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BRCA1-induced large-scale chromatin unfolding and allele-specific effects of cancer-predisposing mutations
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Characterization of a carboxy-terminal BRCA1 interacting protein
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    CCDC98 targets BRCA1 to DNA damage sites
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Compromised BRCA1-PALB2 interaction is associated with breast cancer risk.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ChAM, a novel motif that mediates PALB2 intrinsic chromatin binding and facilitates DNA repair
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BRCA1 interacts with FHL2 and enhances FHL2 transactivation function
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    TRIP12 and UBR5 suppress spreading of chromatin ubiquitylation at damaged chromosomes
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BRCA1 affects lipid synthesis through its interaction with acetyl-CoA carboxylase
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    PALB2 is an integral component of the BRCA complex required for homologous recombination repair
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    MDC1 is a mediator of the mammalian DNA damage checkpoint
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    ATM activation by ionizing radiation requires BRCA1-associated BAAT1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    DNA Repair Network Analysis Reveals Shieldin as a Key Regulator of NHEJ and PARP Inhibitor Sensitivity.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BRCA1 is a negative modulator of the PRC2 complex
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A member of the Pyrin family, IFI16, is a novel BRCA1-associated protein involved in the p53-mediated apoptosis pathway
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Sequence-specific transcriptional corepressor function for BRCA1 through a novel zinc finger protein, ZBRK1
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    A mechanism for the suppression of homologous recombination in G1 cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Ligand-dependent differences in estrogen receptor beta-interacting proteins identified in lung adenocarcinoma cells corresponds to estrogenic responses.
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    The FANCJ/MutLalpha interaction is required for correction of the cross-link response in FA-J cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BRCA1 participates in DNA decatenation
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Interplay between BRCA1 and RHAMM regulates epithelial apicobasal polarization and may influence risk of breast cancer
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BRCA1 regulates the G2/M checkpoint by activating Chk1 kinase upon DNA damage
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Structural determinants of the BRCA1 : estrogen receptor interaction
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    BAP1: a novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCA1-mediated cell growth suppression
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Toward an understanding of the protein interaction network of the human liver
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    RNF8 ubiquitylates histones at DNA double-strand breaks and promotes assembly of repair proteins
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    Functional consequences of cyclin D1/BRCA1 interaction in breast cancer cells
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    retrieved
    8 April 2019
    stated in
    NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain
    GOA
    curator
    IntAct protein interaction database
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IPI
    ubiquitin-protein transferase activity
    determination method or standard
    IEA
    IDA
    5 references
    retrieved
    16 July 2018
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P38398&geneProductId=UniProtKB:P38398
    determination method or standard
    IEA
    retrieved
    16 July 2018
    stated in
    BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P38398&geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P38398&geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    The UBXN1 Protein Associates with Autoubiquitinated Forms of the BRCA1 Tumor Suppressor and Inhibits Its Enzymatic Function
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P38398&geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P38398&geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    ubiquitin-protein transferase activity
    determination method or standard
    IBA
    IDA
    IEA
    6 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The UBXN1 Protein Associates with Autoubiquitinated Forms of the BRCA1 Tumor Suppressor and Inhibits Its Enzymatic Function
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    A critical role for the ubiquitin-conjugating enzyme Ubc13 in initiating homologous recombination
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IBA
    cell component
    BRCA1-A complex
    determination method or standard
    IDA
    5 references
    retrieved
    16 July 2018
    stated in
    NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P38398&geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    MERIT40 facilitates BRCA1 localization and DNA damage repair
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P38398&geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P38398&geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P38398&geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    16 July 2018
    stated in
    Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?protein=P38398&geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    nucleus
    determination method or standard
    IEA
    IDA
    6 references
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IEA
    retrieved
    8 April 2019
    stated in
    CCDC98 targets BRCA1 to DNA damage sites
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Identification of DBC1 as a transcriptional repressor for BRCA1
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Localization of BRCA1 protein in breast cancer tissue and cell lines with mutations
    GOA
    curator
    Community Assessment of Community Annotation with Ontologies
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    BRCA1-BARD1 complex
    determination method or standard
    IBA
    IDA
    5 references
    retrieved
    8 April 2019
    stated in
    BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    BRCA1-associated protein 1 interferes with BRCA1/BARD1 RING heterodimer activity
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The UBXN1 Protein Associates with Autoubiquitinated Forms of the BRCA1 Tumor Suppressor and Inhibits Its Enzymatic Function
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    The BRCA1/BARD1 heterodimer assembles polyubiquitin chains through an unconventional linkage involving lysine residue K6 of ubiquitin
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IBA
    BRCA1-A complex
    determination method or standard
    IBA
    IDA
    6 references
    retrieved
    8 April 2019
    stated in
    MERIT40 facilitates BRCA1 localization and DNA damage repair
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    RAP80 targets BRCA1 to specific ubiquitin structures at DNA damage sites
    GOA
    curator
    UniProt
    UniProt protein ID
    P38398
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IDA
    retrieved
    8 April 2019
    stated in
    Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
    GOA
    curator
    GO Central
    reference URL
    http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P38398
    determination method or standard
    IBA
    biological process
    Commons category
    BRCA1
    0 references

    Identifiers

    MeSH descriptor ID
    D019313
    subject named as
    BRCA1 Protein
    0 references
    Ensembl protein ID
    Freebase ID
    /m/0256r1
    0 references
    OMIM ID
    113705
    0 references
    PDB structure ID
     
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