Heparan sulfate proteoglycan 2 (Q2071346)

LDL receptor-like superfamily

1 reference

Immunoglobulin-like domain superfamily

1 reference

Concanavalin A-like lectin/glucanase domain superfamily

1 reference

Immunoglobulin I-set, protein family

1 reference

Laminin G domain, protein family

1 reference

SEA domain, protein family

1 reference

immunoglobulin subtype, protein family

1 reference

Immunoglobulin V-set domain, protein family

1 reference

Laminin EGF domain, protein family

1 reference

Laminin IV domain, protein family

1 reference

EGF-like calcium-binding domain, protein family

1 reference

Immunoglobulin subtype 2, protein family

1 reference

immunoglobulin-like domain, protein family

1 reference

EGF-like domain, protein family

1 reference

Low-density lipoprotein (LDL) receptor class A, conserved site, protein family

1 reference

EGF-like, conserved site, protein family

1 reference

Low-density lipoprotein (LDL) receptor class A repeat, protein family

1 reference

image

Protein HSPG2 PDB 1gl4.png
925 × 744; 315 KB

0 references

1 reference

13 November 2019

1 reference

13 November 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 reference

9 May 2019

protein binding

3 references

9 May 2019

The type XIII collagen ectodomain is a 150-nm rod and capable of binding to fibronectin, nidogen-2, perlecan, and heparin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

Endorepellin, the angiostatic module of perlecan, interacts with both the α2β1 integrin and vascular endothelial growth factor receptor 2 (VEGFR2): a dual receptor antagonism

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

Endorepellin laminin-like globular 1/2 domains bind Ig3-5 of vascular endothelial growth factor (VEGF) receptor 2 and block pro-angiogenic signaling by VEGFA in endothelial cells

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

calcium ion binding

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 reference

9 May 2019

protein C-terminus binding

1 reference

9 May 2019

Perlecan protein core interacts with extracellular matrix protein 1 (ECM1), a glycoprotein involved in bone formation and angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

amyloid-beta binding

IC

1 reference

9 May 2019

Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-β Uptake

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

extracellular matrix structural constituent conferring compression resistance

IC

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98160&geneProductId=UniProtKB:P98160

1 January 2018

Comprehensive proteomic characterization of stem cell-derived extracellular matrices

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98160&geneProductId=UniProtKB:P98160

1 January 2018

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98160&geneProductId=UniProtKB:P98160

1 January 2018

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98160&geneProductId=UniProtKB:P98160

1 January 2018

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98160&geneProductId=UniProtKB:P98160

1 January 2018

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?protein=P98160&geneProductId=UniProtKB:P98160

low-density lipoprotein particle receptor binding

1 reference

9 May 2019

Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-β Uptake

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

extracellular matrix structural constituent conferring compression resistance

Proteomics characterization of extracellular space components in the human aorta

13 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 January 2018

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 January 2018

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 January 2018

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 January 2018

Comprehensive proteomic characterization of stem cell-derived extracellular matrices

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 January 2018

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 January 2018

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 January 2018

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 January 2018

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 January 2018

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 January 2018

Comprehensive proteomic characterization of stem cell-derived extracellular matrices

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 January 2018

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

extracellular matrix structural constituent conferring compression resistance

Comprehensive proteomic characterization of stem cell-derived extracellular matrices

7 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

cell component

basement membrane

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160

1 reference

3 January 2017

Golgi lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 reference

9 May 2019

extracellular exosome

5 references

3 January 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160

3 January 2017

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160

3 January 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160

3 January 2017

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160

3 January 2017

Protein profile of exosomes from trabecular meshwork cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160

lysosomal lumen

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 reference

9 May 2019

extracellular region

2 references

plasma membrane

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 reference

9 May 2019

extracellular matrix

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury

4 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160

3 January 2017

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160

3 January 2017

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160

3 January 2017

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160

focal adhesion

1 reference

3 January 2017

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160

extracellular region

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

3 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

9 May 2019

Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

basement membrane

Perlecan and basement membrane-chondroitin sulfate proteoglycan (bamacan) are two basement membrane chondroitin/dermatan sulfate proteoglycans in the Engelbreth-Holm-Swarm tumor matrix

3 references

8 April 2019

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

8 April 2019

Perlecan domain V inhibits α2 integrin-mediated amyloid-β neurotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

8 April 2019

focal adhesion

1 reference

9 May 2019

Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

collagen-containing extracellular matrix

Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury

8 references

9 May 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

Comprehensive proteomic characterization of stem cell-derived extracellular matrices

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

Proteomics characterization of extracellular space components in the human aorta

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

Extracellular matrix signatures of human primary metastatic colon cancers and their metastases to liver.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

SILAC-based proteomics of human primary endothelial cell morphogenesis unveils tumor angiogenic markers

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

Glycoproteomics Reveals Decorin Peptides With Anti-Myostatin Activity in Human Atrial Fibrillation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

Characterization of the Extracellular Matrix of Normal and Diseased Tissues Using Proteomics.

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

extracellular exosome

4 references

9 May 2019

Protein profile of exosomes from trabecular meshwork cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

Large-scale proteomics and phosphoproteomics of urinary exosomes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

plasma membrane protein complex

1 reference

9 May 2019

Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-β Uptake

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

basement membrane

Perlecan and basement membrane-chondroitin sulfate proteoglycan (bamacan) are two basement membrane chondroitin/dermatan sulfate proteoglycans in the Engelbreth-Holm-Swarm tumor matrix

4 references

9 May 2019

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

Perlecan domain V inhibits α2 integrin-mediated amyloid-β neurotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

9 May 2019

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

glycosaminoglycan metabolic process

biological process

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160

1 reference

3 January 2017

extracellular matrix disassembly

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P98160

1 reference

3 January 2017

retinoid metabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 reference

9 May 2019

glycosaminoglycan biosynthetic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 reference

9 May 2019

glycosaminoglycan catabolic process

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 reference

9 May 2019

angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 reference

9 May 2019

extracellular matrix organization

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 reference

9 May 2019

lipid metabolism

1 reference

9 May 2019

Heparan Sulphate Proteoglycan and the Low-Density Lipoprotein Receptor-Related Protein 1 Constitute Major Pathways for Neuronal Amyloid-β Uptake

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

receptor-mediated endocytosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

1 reference

9 May 2019

inflammatory response

1 reference

9 May 2019

Perlecan domain V inhibits α2 integrin-mediated amyloid-β neurotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

brain development

1 reference

9 May 2019

Perlecan domain V inhibits α2 integrin-mediated amyloid-β neurotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

negative regulation of angiogenesis

1 reference

9 May 2019

Perlecan domain V inhibits α2 integrin-mediated amyloid-β neurotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

cell differentiation

1 reference

9 May 2019

Perlecan domain V inhibits α2 integrin-mediated amyloid-β neurotoxicity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

animal organ morphogenesis

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

tissue development

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

cell migration

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

substrate adhesion-dependent cell spreading

1 reference

9 May 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P98160

Gene Atlas image

PBB GE HSPG2 201655 s at fs.png
732 × 530; 11 KB

0 references

has part(s)

immunoglobulin subtype 2

1 reference

Low-density lipoprotein (LDL) receptor class A, conserved site

1 reference

Laminin G domain

1 reference

immunoglobulin-like domain

1 reference

EGF-like, conserved site

1 reference

low-density lipoprotein (LDL) receptor class A repeat

1 reference

immunoglobulin subtype

1 reference

immunoglobulin I-set

1 reference

EGF-like calcium-binding domain

1 reference

EGF-like domain

1 reference

Laminin IV

1 reference

immunoglobulin V-set domain

1 reference

SEA domain

1 reference

Laminin EGF domain

1 reference