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FURIN (Q14916427)

From Wikidata
protein-coding gene in the species Homo sapiens
  • FUR
  • PACE
  • PCSK3
  • SPC1
  • furin, paired basic amino acid cleaving enzyme
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    English
    FURIN
    protein-coding gene in the species Homo sapiens
    • FUR
    • PACE
    • PCSK3
    • SPC1
    • furin, paired basic amino acid cleaving enzyme

    Statements

    image
    Protein FURIN PDB 1p8j.png
    996 × 593; 704 KB
    0 references
    molecular function
    serine-type endopeptidase activity
    determination method or standard
    IDA
    IEA
    IMP
    TAS
    6 references
    retrieved
    9 May 2017
    stated in
    GOA
    curator
    Reactome
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958
    determination method or standard
    TAS
    retrieved
    9 May 2017
    stated in
    The ordered and compartment-specfific autoproteolytic removal of the furin intramolecular chaperone is required for enzyme activation
    GOA
    curator
    UniProt
    UniProt protein ID
    P09958
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958
    determination method or standard
    IMP
    retrieved
    9 May 2017
    stated in
    Activation of the furin endoprotease is a multiple-step process: requirements for acidification and internal propeptide cleavage
    GOA
    curator
    UniProt
    UniProt protein ID
    P09958
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958
    determination method or standard
    IMP
    retrieved
    9 May 2017
    stated in
    GOA
    curator
    InterPro
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958
    determination method or standard
    IEA
    retrieved
    9 May 2017
    stated in
    Cellular processing of the nerve growth factor precursor by the mammalian pro-protein convertases
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958
    determination method or standard
    IDA
    retrieved
    9 May 2017
    stated in
    The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958
    determination method or standard
    IDA
    cell component
    biological process
    protein processing
    determination method or standard
    IDA
    IEA
    IMP
    8 references
    retrieved
    9 May 2017
    stated in
    Human carcinoma cell growth and invasiveness is impaired by the propeptide of the ubiquitous proprotein convertase furin
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958
    determination method or standard
    IMP
    retrieved
    9 May 2017
    stated in
    GOA
    curator
    Ensembl genome database project
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958
    determination method or standard
    IEA
    retrieved
    9 May 2017
    stated in
    Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia
    GOA
    curator
    UniProt
    UniProt protein ID
    P09958
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958
    determination method or standard
    IDA
    retrieved
    9 May 2017
    stated in
    Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin
    GOA
    curator
    Mouse Genome Informatics
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958
    determination method or standard
    IDA
    retrieved
    9 May 2017
    stated in
    Processing of Prothyrotropin-releasing Hormone by the Family of Prohormone Convertases
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958
    determination method or standard
    IDA
    retrieved
    9 May 2017
    stated in
    Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958
    determination method or standard
    IDA
    retrieved
    9 May 2017
    stated in
    Proprotein convertase furin interacts with and cleaves pro-ADAMTS4 (Aggrecanase-1) in the trans-Golgi network
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958
    determination method or standard
    IDA
    retrieved
    9 May 2017
    stated in
    The prosegments of furin and PC7 as potent inhibitors of proprotein convertases. In vitro and ex vivo assessment of their efficacy and selectivity
    GOA
    curator
    British Heart Foundation
    reference URL
    http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P09958
    determination method or standard
    IDA
    Gene Atlas image
    PBB GE FURIN 201945 at fs.png
    732 × 530; 12 KB
    0 references
    Commons category
    Furin
    0 references

    Identifiers

    DeCS ID
    38168
    0 references
    Freebase ID
    /m/0d2k4g
    0 references
     
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