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    English: a The molecular association of tetraspanin and its partner proteins is mediated through both the TM and LEL regions, but its dependency is different among the partner proteins. Lipid binding to the central cavity could modulate the molecular association by affecting the LEL conformation. b The highly asymmetric shape of the tetraspanins suggests their localization at high curvature regions and/or clustering-induced curvature generation. Partner proteins should also be recruited and sorted to the respective regions, such as the microvilli tips and microsomes (exosomes).[1]
    Date
    Source https://doi.org/10.1038/s41467-020-15459-7
    Author Rie Umeda, Yuhkoh Satouh, Mizuki Takemoto, Yoshiko Nakada-Nakura, Kehong Liu, Takeshi Yokoyama, Mikako Shirouzu, So Iwata, Norimichi Nomura, Ken Sato, Masahito Ikawa, Tomohiro Nishizawa & Osamu Nureki

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    Hypothetical model of the tetraspanin function

    inception

    30 March 2020

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    current22:54, 4 April 2020Thumbnail for version as of 22:54, 4 April 2020825 × 300 (936 KB)Rob HurtUploaded a work by Rie Umeda, Yuhkoh Satouh, Mizuki Takemoto, Yoshiko Nakada-Nakura, Kehong Liu, Takeshi Yokoyama, Mikako Shirouzu, So Iwata, Norimichi Nomura, Ken Sato, Masahito Ikawa, Tomohiro Nishizawa & Osamu Nureki from https://doi.org/10.1038/s41467-020-15459-7 with UploadWizard

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